■分析脊髓损伤(SCI)后重度抑郁症(MDD)的危险因素。
■选择2020年2月至2023年2月在我院就诊的SCI患者作为研究对象。根据汉密尔顿抑郁量表(HAMD)评分,将36~75分的患者纳入重度抑郁组,非重度抑郁组分为0~35分。一般社会学特征(年龄,性别,教育水平,居住地,家庭经济状况,医疗费用的支付方式,婚姻状况)和疾病相关特征(病程,受伤原因,神经损伤程度,损伤类型,收集所有患者的疼痛程度),选取差异项进行logistic回归分析,分析脊髓损伤患者发生重度抑郁的危险因素。
■共216名患者被纳入我们的研究,其中45例(18.98%)患有中重度抑郁症,175例(81.02%)患有非重度抑郁症.单因素分析显示性别(χ2=11.865,P<.001),病程(χ2=12.967,P<.001),家庭经济状况(χ2=8.610,P=0.003),受教育程度(χ2=15.287,P<.001),神经损伤程度(χ2=9.013,P=.003)和疼痛程度(χ2=16.673,P<.001)两组间差异均有统计学意义。多因素logistic回归分析显示,性别[比值比(OR)(95%CI)=3.986(1.743~9.116),P=.001],病程[OR(95%CI)=4.033(1.818~8.947),P=.001],家庭经济状况[OR(95%CI)=3.136(1.449~6.785),P=.004],教育水平[OR(95%CI)=4.332(1.998~9.388),P=.000],神经损伤程度[OR(95%CI)=2.848(1.414~5.734),P=.003],和疼痛水平[OR(95%CI)=5.767(2.309~14.404),P<.001]是SCI患者重度抑郁障碍的危险因素。
■性别,疾病持续时间,家庭经济状况,教育水平,神经损伤程度,疼痛程度可能是脊髓损伤患者发生MDD的独立危险因素。
UNASSIGNED: To analyze the risk factors of major depressive disorder (MDD) after spinal cord injury (SCI).
UNASSIGNED: Patients with SCI in our hospital from February 2020 to February 2023 were selected as the study objects. According to the Hamilton Depression Scale (HAMD) score, patients with 36~75 points were included in the major depression group, and 0~35 points were included in the non-major depression group. The general sociological characteristics (age, gender, educational level, place of residence, family economic status, payment method of medical expenses, marital status) and disease-related characteristics (course of disease, cause of injury, neurological level of injury, type of injury, degree of pain) of all patients were collected, and the items with differences were selected for logistic regression analysis to analyze the risk factors for major depression in patients with spinal cord injury.
UNASSIGNED: Totally 216 patients were enrolled in our study, including 45 patients (18.98%) had moderate-to-severe depression and 175 patients (81.02%) had non-severe depression. Univariate analysis showed that gender (χ2 = 11.865, P < .001), course of disease (χ2 = 12.967, P < .001), family economic status (χ2 = 8.610, P = .003), educational level (χ2 =15.287, P < .001), neurological level of injury (χ2 = 9.013, P = .003) and pain level (χ2 = 16.673, P < .001) were statistically significant differences between the 2 groups. Multivariate logistic regression analysis showed that gender [odds ratio (OR) (95 % CI) = 3.986 (1.743~9.116), P = .001], course of disease [OR (95 % CI) = 4.033 (1.818~8.947), P = .001], family economic status [OR (95 % CI) = 3.136 (1.449~6.785), P = .004], educational level [OR (95 % CI) = 4.332 (1.998~9.388), P = .000], neurological level of injury [OR (95 % CI) = 2.848 (1.414~5.734), P = .003], and pain level [OR (95 % CI) = 5.767 (2.309~14.404), P < .001] were risk factors for major depressive disorder in SCI patients.
UNASSIGNED: Gender, disease duration, family economic status, education level, level of nerve injury, and pain level may be the independent risk factors of MDD incidence in patients with spinal cord injury.