■本研究回顾性评估了液基细胞学(LBC)在大样本中诊断胰腺囊性肿瘤(PCN)的价值,并初步估计了可能影响LBC诊断能力的因素。
■从2015年4月到2022年10月,我们在我们的前瞻性数据库中前瞻性招募了331名疑似PCN患者。其中,选择接受手术切除的112例患者包括在内。最终仅研究了96例接受EUS引导的囊性液体LBC的患者。评估了LBC对良恶性PCN和PCN亚型的诊断价值。
■有71名女性和25名男性患者,平均年龄为47.6±14.4岁。囊肿中位大小为43.4mm。诊断的准确性,灵敏度,特异性,正预测值,LBC对良恶性PCN的阴性预测值为96.9%,57.1%,100%,100%,96.7%,分别。LBC对特定囊肿类型的总体诊断准确率为33.3%(32/96)。位于胰腺体/尾部或不规则形状的囊肿更有可能获得明确的LBC诊断。同时,年龄,性别,肿瘤大小,囊性液体粘度,操作时间,针头类型,和隔膜的存在没有显着差异。
■液基细胞学单独用于区分良性PCN和恶性PCN,并且可以成功表征三分之一患者的PCN亚型。位于体/尾部或表现出不规则形状的胰腺囊性肿瘤更有可能获得明确的LBC诊断。
UNASSIGNED: This study retrospectively evaluated the value of liquid-based cytology (LBC) alone for diagnosing pancreatic cystic neoplasms (PCNs) in a large sample and initially estimated factors that might affect LBC diagnostic ability.
UNASSIGNED: From April 2015 to October 2022, we prospectively enrolled 331 patients with suspected PCNs in our prospective database. Among them, 112 patients chosen to receive surgical resection were included. Only 96 patients who underwent EUS-guided cystic fluid LBC were finally studied. The diagnostic values of LBC for differentiating benign and malignant PCNs and subtypes of PCNs were evaluated.
UNASSIGNED: There were 71 female and 25 male patients with a mean age of 47.6 ± 14.4 years. The median cyst size was 43.4 mm. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of LBC for the differentiation of benign and malignant PCNs were 96.9%, 57.1%, 100%, 100%, and 96.7%, respectively. The overall diagnostic accuracy of LBC for specific cyst types was 33.3% (32/96). Cysts located in the pancreatic body/tail or with irregular shapes were more likely to obtain a definite LBC diagnosis. At the same time, age, sex, tumor size, cystic fluid viscosity, operation time, needle type, and presence of septation were not significantly different.
UNASSIGNED: Liquid-based cytology alone is useful for differentiating benign PCNs from malignant PCNs and can successfully characterize the PCN subtypes in one-third of patients. Pancreatic cystic neoplasms located in the body/tail or exhibiting irregular shapes are more likely to obtain a definite LBC diagnosis.