PDF(Pubmed)
Abstract：
The evolutionary journey of cervical cancer screening has been a major medical success story, considering the substantial role it has played in dwindling the disease burden. Through sustained collaborative efforts within the medical community, significant advances have been made from the humble yet path-breaking conventional Pap smear to the current automated screening systems and human papillomavirus (HPV) molecular testing. With the integration of artificial intelligence into screening techniques, we are currently at the precipice of circumventing the pitfalls of manual cytology readings and improving the efficiency of the screening systems by a significant margin. Despite the technological milestones traversed, the high logistics and operational cost, besides the technical know-how of operating the automated systems, can pose a major practical challenge in the widespread adoption of these advanced techniques in cervical cancer screening programs. This would suggest the need to adopt strategies that are tailored to the demands and needs of the different settings keeping their limitations in mind. This review aims to take the reader through the entire evolutionary journey of cervical cancer screening programs, highlight the individual merits and demerits of each technique, and discuss the recommendations from the major global guidelines.
摘要：
宫颈癌筛查的进化历程一直是一个重大的医学成功故事，考虑到它在减少疾病负担方面发挥的重要作用。通过医学界的持续合作，从不起眼但开创性的常规巴氏涂片到目前的自动筛查系统和人乳头瘤病毒（HPV）分子检测，已经取得了重大进展。随着人工智能与筛查技术的融合,我们目前正处于规避手动细胞学读数陷阱和显著提高筛查系统效率的边缘。尽管经历了技术里程碑，高昂的物流和运营成本，除了操作自动化系统的技术诀窍，在宫颈癌筛查计划中广泛采用这些先进技术可能会带来重大的实际挑战。这表明有必要采取针对不同环境的需求和需求的战略，同时牢记其局限性。这篇综述旨在让读者了解宫颈癌筛查计划的整个进化历程，突出每种技术的优点和缺点，并讨论主要全球准则的建议。
