language disorders

语言障碍
  • 文章类型: Journal Article
    有语言困难的人不能面对与社交技能相关的挑战。这些语言障碍会影响学业,工作环境,和社会互动,导致适应不良和攻击行为。年轻囚犯很有可能遇到无法识别的语言缺陷。是的,因此,有必要分析可能影响犯罪行为(毒品持有/消费和性别暴力犯罪)的语言病理学。有许多标准化的测试来评估和检测英语成人的语言障碍。然而,西班牙语的选项相对较少;没有定性和深入评估语言的测试。大多数研究是针对儿童和青少年进行的。
    提出一种可靠的编码系统,用于纠正和解释被控拥有毒品或毒品的囚犯的写作过程评估(PROESC)中的叙述(论文和叙述)。消费和性别暴力犯罪。
    样本由287名男性组成。
    他们完成了人口统计,冒犯,和机构中的行为访谈,国际人格障碍考试(IPDE),和PROESC。
    我们发现所提出的编码系统具有很高的一致性,也就是说,较高的评分者间可靠性。
    用于纠正和解释叙述的分类系统被证明是可靠的。
    UNASSIGNED: People with language difficulties cannot face challenges related to social skills. Those language disorders affect academic, work environments, and social interaction, leading to maladaptive and aggressive behaviors. Young inmates are at high risk of experiencing unrecognized language deficiencies. It is, therefore, necessary to analyze linguistic pathologies that can influence criminal behavior (drugs possession/consumption and gender violence crimes). There are many standardized tests to evaluate and detect language difficulties in adults in English. However, there are relatively few options in Spanish; there are no tests that evaluate language qualitatively and in depth. Most of the research is conducted with children and adolescents.
    UNASSIGNED: To propose a reliable coding system for the correction and interpretation of narratives (essays and narratives) from the Battery for the Evaluation of Writing Processes (PROESC) in the prisoners charged of drugs possession or consumption and gender violence crimes.
    UNASSIGNED: The sample was composed of 287 men.
    UNASSIGNED: They completed the Demographic, Offense, and Behavioral Interview in Institutions, the International Personality Disorders Examination (IPDE), and PROESC.
    UNASSIGNED: We found that the proposed coding system presented high concordance, that is, high inter-rater reliability.
    UNASSIGNED: The classification system for the correction and interpretation of narratives was shown to be reliable.
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  • 文章类型: Journal Article
    The S3 Guideline on the Treatment of Language Development Disorders: Summary of Recommendations Abstract: The German S3 Guidelines on the Treatment of Developmental Speech and Language Disorders (AWMF: No. 049-015) were published on the AWMF homepage at the end of 2022. The German Society for Phoniatrics and Paedaudiologie coordinated the work and developed the guideline text together with linguists and speech and language therapists. Many scientific medical societies consented to the respective recommendations. For the first time in the German-speaking area, the guideline group reviewed international research results on the treatment of various speech and language disorders and formulated evidence- or consensus-based recommendations for clinical care. The present article summarizes these recommendations and evaluates the guidelines from the perspective of child and adolescent psychiatry and psychotherapy.
    Zusammenfassung: Die S3-Leitlinie zur Therapie von Sprachentwicklungsstörungen (AWMF: Nr. 049-015), die Ende 2022 auf der Homepage der AWMF veröffentlich wurde, ist unter Federführung der Deutschen Gesellschaft für Phoniatrie und Pädaudiologie in Kooperation mit zahlreichen Sprachwissenschaftler_innen und Sprachtherapeut_innen entwickelt und von zahlreichen wissenschaftlichen medizinischen Fachgesellschaften konsentiert worden. Die Leitliniengruppe hat erstmalig für den deutschen Sprachraum versucht, die internationale Studienlage zur Therapie unterschiedlicher Sprach- und Sprechstörungen aufzuarbeiten und darauf basierend Evidenz- oder auch Konsensus-basierte Empfehlungen für die klinische Versorgung zu formulieren. In dem vorliegenden Artikel werden diese Empfehlungen zusammenfassend dargestellt, und es wird eine Wertung der Leitlinie aus Kinder- und Jugendpsychiatrischer Sicht vorgenommen.
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  • 文章类型: Journal Article
    背景:早期识别语言障碍可以帮助儿童获得改善发育结果和生活质量所需的支持。尽管持续的语言障碍的流行和影响,令人惊讶的是,没有强大的预测工具可用。这使得研究人员很难招募幼儿参加早期干预试验,这反过来又阻碍了向需要的儿童提供有效的早期干预措施的进展。
    目的:为了从外部验证先前确定的可预测11岁时语言的六个变量的预测集,使用澳大利亚儿童纵向研究(LSAC)出生队列的数据。此外,检查是否产生了其他LSAC变量来预测语言结果。
    方法:总共5107名儿童被招募到LSAC,收集了0至3岁的发育测量值。在11-12岁的时候,儿童完成了语言基础的临床评估,第4版,回顾句子子测试。我们使用SuperLearner来估计先前确定的来自2-3岁的父母报告的六个变量在预测11-12岁时的低语言(句子回忆得分比平均值低1.5SD)的准确性。随机森林用于识别预测语言结果的任何其他变量。
    结果:523名参与者(52.20%的女孩)获得了完整的数据,其中27人(5.16%)的语言得分较低。六个预测因子产生了相当的准确性:78%的灵敏度(95%置信区间(CI)=[58,91])和71%的特异性(95%CI=[67,75])。这些预测因素与句子复杂性有关,词汇和行为。随机森林分析确定了相似的预测因子。
    结论:我们确定了一组超短变量,可预测11-12年的语言结果,并具有“公平”的准确性。在该领域对这种规模的少数复制研究中,这些方法现在已经在两个基于人群的队列中进行,结果一致。这些发现的迫在眉睫的实际意义是使用这些预测因子来帮助招募早期语言干预研究。未来的研究可以继续完善早期预测因子的准确性,以在临床背景下进行早期识别。
    结论:关于该主题的已知因素尽管儿童语言障碍的患病率和深远的影响,但尚无可靠的预测集。先前的一项研究确定了在2-3岁时收集的六个变量,这些变量以75%的灵敏度和81%的特异性预测11-12岁的语言。这保证在单独的队列中复制。我们使用机器学习方法来识别一组2-3岁时提出的六个问题,其敏感性和特异性≥71%,用于预测11-12岁时的低语言结果。目前在两项基于人群的大规模队列研究中显示出一致的结果.这项工作的潜在或临床意义是什么?这个预测集比现有的可行方法更准确,可以转化为早期语言干预研究的低资源和时间效率的招募工具,从而改善为可能持续有语言障碍的幼儿提供的临床服务。
    BACKGROUND: Identifying language disorders earlier can help children receive the support needed to improve developmental outcomes and quality of life. Despite the prevalence and impacts of persistent language disorder, there are surprisingly no robust predictor tools available. This makes it difficult for researchers to recruit young children into early intervention trials, which in turn impedes advances in providing effective early interventions to children who need it.
    OBJECTIVE: To validate externally a predictor set of six variables previously identified to be predictive of language at 11 years of age, using data from the Longitudinal Study of Australian Children (LSAC) birth cohort. Also, to examine whether additional LSAC variables arose as predictive of language outcome.
    METHODS: A total of 5107 children were recruited to LSAC with developmental measures collected from 0 to 3 years. At 11-12 years, children completed the Clinical Evaluation of Language Fundamentals, 4th Edition, Recalling Sentences subtest. We used SuperLearner to estimate the accuracy of six previously identified parent-reported variables from ages 2-3 years in predicting low language (sentence recall score ≥ 1.5 SD below the mean) at 11-12 years. Random forests were used to identify any additional variables predictive of language outcome.
    RESULTS: Complete data were available for 523 participants (52.20% girls), 27 (5.16%) of whom had a low language score. The six predictors yielded fair accuracy: 78% sensitivity (95% confidence interval (CI) = [58, 91]) and 71% specificity (95% CI = [67, 75]). These predictors relate to sentence complexity, vocabulary and behaviour. The random forests analysis identified similar predictors.
    CONCLUSIONS: We identified an ultra-short set of variables that predicts 11-12-year language outcome with \'fair\' accuracy. In one of few replication studies of this scale in the field, these methods have now been conducted across two population-based cohorts, with consistent results. An imminent practical implication of these findings is using these predictors to aid recruitment into early language intervention studies. Future research can continue to refine the accuracy of early predictors to work towards earlier identification in a clinical context.
    CONCLUSIONS: What is already known on the subject There are no robust predictor sets of child language disorder despite its prevalence and far-reaching impacts. A previous study identified six variables collected at age 2-3 years that predicted 11-12-year language with 75% sensitivity and 81% specificity, which warranted replication in a separate cohort. What this study adds to the existing knowledge We used machine learning methods to identify a set of six questions asked at age 2-3 years with ≥ 71% sensitivity and specificity for predicting low language outcome at 11-12 years, now showing consistent results across two large-scale population-based cohort studies. What are the potential or clinical implications of this work? This predictor set is more accurate than existing feasible methods and can be translated into a low-resource and time-efficient recruitment tool for early language intervention studies, leading to improved clinical service provision for young children likely to have persisting language difficulties.
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  • 文章类型: Journal Article
    语言障碍,它们仍然很难被检测到,经常出现在受虐待的儿童身上。虽然后果是众所周知的,而且是持久的,对这些孩子的发育和具体特征知之甚少,取决于它们被放置在哪里,他们遭受的虐待类型和他们所处的年龄。这一发现导致了对文献的回顾,旨在更好地定义关于该主题的知识状态,为了更好的检测和治疗。
    Language disorders, which are still very poorly detected, are often present in abused children. While the consequences are well known and long-lasting, little is known about the development and specific characteristics of these children, depending on where they were placed, the type of abuse they suffered and the age at which they were placed. This finding led to a review of the literature aimed at better defining the state of knowledge on the subject, for the benefit of better detection and treatment.
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  • 文章类型: Journal Article
    目标:本教程讨论了语言病理学家(SLP)支持语言障碍患者理解他人的认知和情感状态(心理理论,ToM),特别考虑将这些建议应用于神经发散的个体。
    方法:我通过首先回顾与ToM和语言能力有关的各种语言困难人群的文献来激发本教程,强调需要明确针对语言相关技能,这些技能被认为是语言障碍患者的ToM基础。接下来,我将介绍如何通过基于扫盲的活动来支持ToM的具体示例。在此讨论之后,我通过具体的例子简要描述了如何将这些活动应用于神经发散的个体,例如,在故事书中加入神经发散的角色如何有助于教育孩子理解他人的观点。它进一步强调了讨论不同类型的心理和情绪状态的重要性,这些人分享和不同的神经类型。
    结论:语言技能是ToM能力不可或缺的一部分。SLP在支持客户学术方面发挥着重要作用,识字,和社会成果,并可以通过相关的语言/沟通技巧支持重要的观点接受技能。属于“心理理论”这一总称的各种技能可以适当地纳入干预和基于读写能力的任务中,以尊重神经类型的差异,同时仍为客户建立重要的语言和沟通技巧。
    OBJECTIVE: This tutorial discusses the importance of speech-language pathologists (SLPs) supporting individuals with language disorders in their understanding of others\' cognitive and affective states (theory of mind, ToM), with a special consideration given to applying these suggestions with individuals who are neurodivergent.
    METHODS: I motivate this tutorial by first reviewing the literature related to ToM and language abilities for various populations of individuals with language difficulties, highlighting the need for explicitly targeting the language-related skills that are thought to underlie ToM for individuals with language disorders. I next present concrete examples of how to support ToM through literacy-based activities. I follow this discussion with a short description of how these activities may be applied with individuals who are neurodivergent through concrete examples, such as how inclusion of neurodivergent characters in storybooks can aid in educating children about understanding others\' perspectives. It further emphasizes the importance of discussing various types of mental and emotional states for individuals who share as well as differ in their neurotypes.
    CONCLUSIONS: Language skills are an integral part of ToM abilities. SLPs play an important role in supporting clients\' academic, literacy, and social outcomes and can support important perspective-taking skills through associated language/communication skills. The various skills that fall under the umbrella term \'theory of mind\' can be appropriately incorporated into intervention and literacy-based tasks in a way that respects differences in neurotype while still building important language and communication skills for clients.
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  • 文章类型: Journal Article
    背景:有新的研究表明,患有脑瘫(CP)的儿童和年轻人(CYAs)患注意力缺陷/多动障碍(ADHD)的风险更高。然而,对这些共同发生的疾病的CYAs的临床和功能特征知之甚少。
    目的:评估CYAs与CP的ADHD诊断与临床和功能特征之间的关联。
    方法:本回顾性研究,横断面研究使用了CYAs(4-26岁)合并CP(n=1145)的电子健康记录数据.我们使用双变量和多变量分析来估计ADHD诊断之间的关联,CP类型,粗大运动功能分类系统(GMFCS)水平,言语或语言障碍,智力残疾。
    结果:18.1%的CYAs伴CP诊断为ADHD。痉挛-双侧CP的CYAs患ADHD的几率较低(调整后的优势比[AOR]=0.58;95%置信区间[CI],0.35-0.96)。对于GMFCS水平为III-V的患者,患有ADHD的几率显着降低(AOR=0.10;95%CI,0.06-0.15)。
    结论:我们的研究发现,与没有ADHD的人相比,在有CP的CYAs中诊断为ADHD与更大的临床和功能损害相关。研究结果强调,由于该人群的合并症率高,因此需要对这两种情况进行筛查。
    BACKGROUND: Emerging research shows that children and young adults (CYAs) with cerebral palsy (CP) are at higher risk for attention-deficit/hyperactivity disorder (ADHD). However, little is known about the clinical and functional characteristics of CYAs with these co-occurring disorders.
    OBJECTIVE: To estimate associations between a diagnosis of ADHD among CYAs with CP and clinical and functional characteristics.
    METHODS: This retrospective, cross-sectional study used data from the electronic health records of CYAs (aged 4-26 years) with CP (n = 1145). We used bivariate and multivariable analyses to estimate associations between an ADHD diagnosis, CP type, Gross Motor Function Classification System (GMFCS) level, speech or language disorder, and intellectual disability.
    RESULTS: 18.1 % of CYAs with CP had a diagnosis of ADHD. CYAs with spastic-bilateral CP had lower odds of ADHD (adjusted odds ratio [AOR] = 0.58; 95 % confidence interval [CI], 0.35-0.96). Odds of having ADHD were significantly lower for those with GMFCS levels III-V (AOR = 0.10; 95 % CI, 0.06-0.15).
    CONCLUSIONS: Our study found that a diagnosis of ADHD among CYAs with CP was associated with greater clinical and functional impairments compared to counterparts without ADHD. Findings highlight the need to screen for both conditions because of the high comorbidity rates in this population.
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  • 文章类型: Journal Article
    Language disorders may interfere with social integration and affectpersonal development. Beca-use the balance of the stomatognathic system can interfere with language, it is important for speech therapy and dentistry to work together, providing multidisciplinar y Healthcare.
    To analyze the 100 most frequently cited articles on language disorders in children and adolescents and assess the interplay with dentistry by means of a bibliometric analysis.
    A search of the 100 most frequently cited articles up to December 2021 on language disorders was performed in the Web of Science Core Collection database. Four researchers extracted the data on number of citations, title, authors, country, year of publication, journals, study design, prevalent clinical conditions, and area of expertise. The analyses were performed using VOSviewer and Excel.
    The total number of citations ranged from 251 to 1,431. Four articles were cited more than 1,000 times. Bishop DVM (10 articles; 3,653 citations) and Tomblin JD (10 articles; 4,261 citations) were the most frequently cited authors. The institutions with the largest number of publications were the University of Oxford/England (11%) and the University of Kansas/USA (8%). Observational study design was the most frequent (77%). Autism spectrum disorder (18%) and dyslexia (14%) were the most broadly investigated clinical conditions. Speech-language pathology (32%) was the area of expertise with the largest number of articles, and none of the top 100 studies showed interplay with dentistry.
    The 100 most widely cited articles on language disorders are mostly observational, mainly address autism spectrum disorder, and are in the field of speech-language pathology No study reported interplay with dentistry.
    Os disturbios de linguagem podem interferir na integrando social e afetar o desenvolvimento dos individuos. O trabalho multidisciplinar entre fonoaudiologia e odontologia é muito importante para a promogdo da saúde. O equilibrio do sistema estomatognático interfere na linguagem.
    Analisar os100 artigos mais citados sobre distúrbios de linguagem em criannas e adolescentes e verificar a interando com a odontologia por meio de análise bibliométrica.
    Foi realizada uma busca pelos 100 artigos mais citados sobre distúrbios de linguagem na base de dados Web of Science Core Collection até dezembro de 2021. Quatro pesquisadores extrairam os dados referentes a número de citanoes, titulo, autores, país, ano de publicando, periódicos, desenho de estudo, condinoes clínicas prevalentes e área de especializando. As análises foram realizadas utilizando VOSviewer e Excel.
    O número total de citanoes variou de 251 a 1.431. Quatro artigos foram citados mais de 1.000 vezes. Bishop DVM (10 artigos; 3.653 citanoes) e Tomblin JD (10 artigos; 4.261 citanoes) foram os autores mais frequentemente citados. As instituinoes com maior número de publicanoes foram a Universidade de Oxford/Inglaterra (11%) e a Universidade de Kansas/EUA (8%). O desenho de estudo observacional foi o mais frequente (77%). O transtorno do espectro autista (18%) e a dislexia (14%) foram as condinoes clínicas mais amplamente investigadas. A Fonoaudiologia (32%) foi a área de atuando com maior número de artigos e nenhum estudo, entre os top100, mostrou interando com a Odontologia.
    Os 100 artigos mais citados sobre distúrbios de linguagem sdo em sua maioria observacionais, abordam principalmente transtornos do espectro do autismo e estdo na área de fonoaudiologia. Nenhum estudo apresentou interando com a odontologia.
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  • 文章类型: Journal Article
    目的:研究语言在阿尔茨海默病过程中是如何恶化的。
    方法:横截面,进行了观察性研究。通过波士顿诊断性失语症检查(BDAE)评估了使用NINCDS-ARDRA标准诊断为AD并接受治疗剂量乙酰胆碱酯酶抑制剂治疗AD的35例患者。样本包括15例轻度AD患者(MMSE>23,CDR=0或0.5-1.0)和20例中度AD患者(MMSE=13-23,CDR=2)。比较两组在所有语言任务上的结果。
    结果:在BDAE的总分方面,轻度和中度AD组之间存在统计学上的显着差异(95%CI47.10-114.08,t=5.0,DF=21,p=0.000*),以及涉及口头和书面理解的几项任务,语言口头表达和写作。
    结论:研究结果显示在中度阶段发生了重大变化。此外,语言表现的下降与痴呆综合征的恶化有关,独立于社会人口统计学变量。
    To investigate how language deteriorates over the Alzheimer\'s Disease course.
    A cross-sectional, observational study was carried out. 35 patients diagnosed with dementia due to AD using the NINCDS-ARDRA criteria and undergoing treatment for AD with a therapeutic dose of acetylcholinesterase inhibitors were assessed by the Boston Diagnostic Aphasia Examination (BDAE). The sample comprised 15 patients with mild AD (MMSE > 23, CDR = 0 or 0.5‒1.0) and 20 patients with moderate AD (MMSE = 13‒23, CDR = 2). The results for the 2 groups on all language tasks were compared.
    A statistically significant difference was found between the mild and moderate AD groups for total score on the BDAE (95% CI 47.10‒114.08, t = 5.0, DF = 21, p = 0.000*), as well as on several tasks involving oral and writing comprehension, language oral expression and writing.
    The study results showed major changes in the moderate stage. Also, the decline in language performance correlated with the worsening of dementia syndrome, independently of sociodemographic variables.
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  • 文章类型: Journal Article
    学生语言障碍中人格化滥用的患病率不断上升,这对自闭症学生在语言障碍领域构成了重大挑战。虽然先前的研究主要集中在自闭症学生面临的认知障碍上,关于发病的争论仍在继续,严重程度,这些挑战的根源在于他们的课堂行为,对先入为主的观念如何影响人格化滥用的探索有限。这项研究旨在深入研究语言障碍的情感治疗,专门针对人格化滥用,促进从扭曲的感知向规范表达的转变。它旨在查明与人格化滥用有关的主要情感干预措施,并审查影响语言障碍治疗方法的情感因素。
    这项研究涵盖了110名自闭症学生,2至5岁,被诊断为语言障碍,所有临床确定患有自闭症的发育儿科医生在一个著名的医疗机构。在这些孩子中,95人在专门学校上学,而15人位于社区环境中。
    结果显示,所有发育阶段的儿童在语言障碍中都表现出人格化滥用的情况,展示了情感治疗后人格化滥用方面值得注意的增强。重要的是,人格化虐待表现和情感治疗的明显差异可以与自闭症学生在四个年级的同时认知进步有关,根据规范表达式标注的变化。
    这些发现强调了在情感治疗背景下仅仅依靠内在趋势来理解人格化虐待的不足。该研究强调了与语言障碍的情感治疗相关的潜在陷阱,并强调迫切需要额外的研究和精神干预策略。
    UNASSIGNED: The escalating prevalence of personification abuse in language disorders among students poses a substantial challenge for autistic students in the domain of language disorders. While prior research has mainly focused on the cognitive hurdles faced by autistic students, ongoing debates persist about the onset, severity, and roots of these challenges in their classroom behavior, with limited exploration of how preconceived notions impact personification abuse. This study aims to delve into emotional treatments for language disorders, specifically targeting personification abuse, to facilitate the shift from distorted perceptions to normative expression. It seeks to pinpoint the primary emotional interventions linked to instances of personification abuse and scrutinize the emotional factors influencing therapeutic approaches for language disorders.
    UNASSIGNED: The research encompassed a cohort of 110 autistic students, aged 2 to 5 years, diagnosed with language disorders, all clinically determined to have autism by developmental pediatricians at a prestigious medical facility. Among these children, 95 were attending specialized schools, while 15 were situated in community settings.
    UNASSIGNED: The outcomes disclosed that children across all developmental phases displayed instances of personification abuse in language disorders, showcasing noteworthy enhancements in personification abuse following emotional treatment. Significantly, the discernible disparity in personification abuse performance and emotional treatment can be linked to the simultaneous cognitive advancement of autistic students across four grade levels, with variations noted based on normative expressions.
    UNASSIGNED: These findings underscore the insufficiency of solely relying on intrinsic trends to comprehend personification abuse within an emotional treatment context. The study accentuates the potential pitfalls associated with emotional treatment for language disorders and stresses the imperative need for additional research and psychiatric intervention strategies.
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  • 文章类型: Journal Article
    背景:经典发作性皮质基底综合征(CBS)患者表现为不对称肢体失用症和帕金森病。我们有,然而,观察到最初出现言语和/或语言(SL)问题并在几年后发展为CBS的患者(即,SL发作CBS)。我们的目的是比较临床,经典发作CBS与SL发作CBS的神经影像学和病理学特征。
    方法:我们对62例符合CBS标准的患者进行了回顾性队列研究(17例出现经典发作的CBS,45例出现SL发作的CBS)。我们比较了人口统计,临床特征,两组之间使用SPM12的灰质和白质体积丢失,并评估了死亡和尸检患者的病理学和皮质基底变性(CBD)病理学病变计数。
    结果:CBS诊断的中位年龄在经典发作的CBS中为66.4岁,在SL发作的CBS中为73.6岁。经典发作的CBS有更高的肌张力障碍频率,肌阵鸣,和外星肢体现象,而SL发作的CBS的垂直核上凝视麻痹的频率更高。两组的额顶体积均小于对照组,SL发作的CBS在左辅助运动区的体积损失比经典发作的CBS更大。所有3例尸检经典发作的CBS病例(100%)均具有CBD病理学,而8/21的SL发作的CBS病例(38%)具有CBD。经典发作和SL发作CBS之间的病理病变负担(包括星形细胞斑块)没有差异。
    结论:经典发作和SL发作的CBS似乎是不同的综合征,前者是一种更严重的运动综合征。SL发作CBS中更广泛的体积损失可能反映了更长的病程。
    BACKGROUND: Patients with classic-onset corticobasal syndrome (CBS) present with asymmetric limb apraxia and parkinsonism. We have, however, observed patients who initially present with speech and/or language (SL) problems and several years later develop CBS (i.e., SL-onset CBS). We aimed to compare clinical, neuroimaging and pathological characteristics of classic-onset CBS with SL-onset CBS.
    METHODS: We conducted a retrospective cohort study of 62 patients who met criteria for CBS (17 presented with classic-onset CBS and 45 had SL-onset CBS). We compared demographics, clinical characteristics, and grey and white matter volume loss with SPM12 between groups and assessed pathology and corticobasal degeneration (CBD) pathological lesion counts in patients who had died and undergone autopsy.
    RESULTS: Median age at CBS diagnosis was 66.4 years in classic-onset CBS and 73.6 years in SL-onset CBS. Classic-onset CBS had higher frequencies of dystonia, myoclonus, and alien limb phenomenon, while SL-onset CBS had a higher frequency of vertical supranuclear gaze palsy. Both groups showed smaller frontoparietal volumes than controls, with SL-onset CBS having greater volume loss in the left supplementary motor area than classic-onset CBS. All three classic-onset CBS cases with autopsy (100 %) had CBD pathology while 8/21 of SL-onset CBS cases (38 %) had CBD. Pathological lesion burden (including astrocytic plaques) did not differ between classic-onset and SL-onset CBS.
    CONCLUSIONS: Classic-onset and SL-onset CBS appear to be different syndromes, with the former being a more profuse motor syndrome. The more widespread volume loss in SL-onset CBS likely reflects longer disease course.
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