PDF(Pubmed)
Abstract：
To investigate how language deteriorates over the Alzheimer\'s Disease course.
A cross-sectional, observational study was carried out. 35 patients diagnosed with dementia due to AD using the NINCDS-ARDRA criteria and undergoing treatment for AD with a therapeutic dose of acetylcholinesterase inhibitors were assessed by the Boston Diagnostic Aphasia Examination (BDAE). The sample comprised 15 patients with mild AD (MMSE > 23, CDR = 0 or 0.5‒1.0) and 20 patients with moderate AD (MMSE = 13‒23, CDR = 2). The results for the 2 groups on all language tasks were compared.
A statistically significant difference was found between the mild and moderate AD groups for total score on the BDAE (95% CI 47.10‒114.08, t = 5.0, DF = 21, p = 0.000*), as well as on several tasks involving oral and writing comprehension, language oral expression and writing.
The study results showed major changes in the moderate stage. Also, the decline in language performance correlated with the worsening of dementia syndrome, independently of sociodemographic variables.
A cross-sectional, observational study was carried out. 35 patients diagnosed with dementia due to AD using the NINCDS-ARDRA criteria and undergoing treatment for AD with a therapeutic dose of acetylcholinesterase inhibitors were assessed by the Boston Diagnostic Aphasia Examination (BDAE). The sample comprised 15 patients with mild AD (MMSE > 23, CDR = 0 or 0.5‒1.0) and 20 patients with moderate AD (MMSE = 13‒23, CDR = 2). The results for the 2 groups on all language tasks were compared.
A statistically significant difference was found between the mild and moderate AD groups for total score on the BDAE (95% CI 47.10‒114.08, t = 5.0, DF = 21, p = 0.000*), as well as on several tasks involving oral and writing comprehension, language oral expression and writing.
The study results showed major changes in the moderate stage. Also, the decline in language performance correlated with the worsening of dementia syndrome, independently of sociodemographic variables.
摘要：
目的：研究语言在阿尔茨海默病过程中是如何恶化的。
方法：横截面，进行了观察性研究。通过波士顿诊断性失语症检查（BDAE）评估了使用NINCDS-ARDRA标准诊断为AD并接受治疗剂量乙酰胆碱酯酶抑制剂治疗AD的35例患者。样本包括15例轻度AD患者（MMSE>23，CDR=0或0.5-1.0）和20例中度AD患者（MMSE=13-23，CDR=2）。比较两组在所有语言任务上的结果。
结果：在BDAE的总分方面，轻度和中度AD组之间存在统计学上的显着差异（95％CI47.10-114.08，t=5.0，DF=21，p=0.000*），以及涉及口头和书面理解的几项任务，语言口头表达和写作。
结论：研究结果显示在中度阶段发生了重大变化。此外，语言表现的下降与痴呆综合征的恶化有关，独立于社会人口统计学变量。
方法：横截面，进行了观察性研究。通过波士顿诊断性失语症检查（BDAE）评估了使用NINCDS-ARDRA标准诊断为AD并接受治疗剂量乙酰胆碱酯酶抑制剂治疗AD的35例患者。样本包括15例轻度AD患者（MMSE>23，CDR=0或0.5-1.0）和20例中度AD患者（MMSE=13-23，CDR=2）。比较两组在所有语言任务上的结果。
结果：在BDAE的总分方面，轻度和中度AD组之间存在统计学上的显着差异（95％CI47.10-114.08，t=5.0，DF=21，p=0.000*），以及涉及口头和书面理解的几项任务，语言口头表达和写作。
结论：研究结果显示在中度阶段发生了重大变化。此外，语言表现的下降与痴呆综合征的恶化有关，独立于社会人口统计学变量。
