language disorders

语言障碍
  • 文章类型: Journal Article
    在有语言障碍的儿童中,同伴互动困难通常会增加,然而,这些困难背后的机制尚不清楚.先前的研究表明,糟糕的冲突管理,社会退出,情绪调节困难,而亲社会行为的减少可能会导致同伴互动困难。然而,这项研究经常使用成人的观点,未能承认孩子对这些经历的看法。本研究旨在从语言障碍儿童的角度定性调查同伴互动的看法。
    7名年龄在7至10岁之间的参与者参加了比赛。所有参与者都被诊断出患有语言障碍,语言是他们的主要困难领域。参与者是从专业语言学校和通过在线数据库招募的。进行了半结构化访谈,参与者可以选择口头或创造性地回答问题,使用玩具或绘图材料。使用解释现象学分析对访谈笔录进行了分析。
    参与者重视游戏,谈话,帮助别人。他们认为与同龄人共度时光可以减轻孤独感。然而,有时需要孤独,因为社交互动可能是压倒性的。参与者发现冲突具有挑战性,并在调节情绪方面表现出困难。参与者依靠逃跑,报复,或者向成年人求助,解决冲突。
    研究结果表明,患有语言障碍的儿童具有社会动机,并且在显示亲社会行为方面具有相对优势。然而,语言障碍儿童需要支持,以促进积极的关系。这种支持包括帮助与同行建立更深层次的联系,有机会在需要的时候独处,并提供熟练的冲突解决和情绪调节策略。
    UNASSIGNED: Peer interaction difficulties are often elevated amongst children with language disorders, yet the mechanisms underlying these difficulties are unclear. Previous research indicates that poor conflict management, social withdrawal, emotion regulation difficulties, and reduced prosocial behavior may contribute to peer interaction difficulties. However, this research often uses adult perspectives, failing to acknowledge child perceptions of these experiences. The present study aimed to qualitatively investigate perceptions of peer interactions from the perspective of children with language disorders.
    UNASSIGNED: Seven participants aged between 7- and 10-years-old took part. All participants were diagnosed with a language disorder and had language as their primary area of difficulty. Participants were recruited from a specialist language school and via an online database. Semi-structured interviews were conducted, with participants given the choice to answer questions verbally or creatively, using toys or drawing materials. Interview transcripts were analyzed using interpretative phenomenological analysis.
    UNASSIGNED: Participants valued play, conversation, and helping others. They felt that spending time with peers could alleviate loneliness. However, sometimes solitude was needed as social interaction could be overwhelming. Participants found conflict challenging and exhibited difficulties with regulating emotions. Participants relied on running away, retaliation, or asking an adult for help, to resolve conflict.
    UNASSIGNED: The findings suggest that children with language disorders are socially motivated and have relative strengths in displaying prosocial behavior. However, children with language disorders require support to promote positive relationships. This support includes help with making deeper connections with peers, opportunities to spend time alone when needed, and providing adept conflict resolution and emotion regulation strategies.
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  • 文章类型: Journal Article
    有语言困难的人不能面对与社交技能相关的挑战。这些语言障碍会影响学业,工作环境,和社会互动,导致适应不良和攻击行为。年轻囚犯很有可能遇到无法识别的语言缺陷。是的,因此,有必要分析可能影响犯罪行为(毒品持有/消费和性别暴力犯罪)的语言病理学。有许多标准化的测试来评估和检测英语成人的语言障碍。然而,西班牙语的选项相对较少;没有定性和深入评估语言的测试。大多数研究是针对儿童和青少年进行的。
    提出一种可靠的编码系统,用于纠正和解释被控拥有毒品或毒品的囚犯的写作过程评估(PROESC)中的叙述(论文和叙述)。消费和性别暴力犯罪。
    样本由287名男性组成。
    他们完成了人口统计,冒犯,和机构中的行为访谈,国际人格障碍考试(IPDE),和PROESC。
    我们发现所提出的编码系统具有很高的一致性,也就是说,较高的评分者间可靠性。
    用于纠正和解释叙述的分类系统被证明是可靠的。
    UNASSIGNED: People with language difficulties cannot face challenges related to social skills. Those language disorders affect academic, work environments, and social interaction, leading to maladaptive and aggressive behaviors. Young inmates are at high risk of experiencing unrecognized language deficiencies. It is, therefore, necessary to analyze linguistic pathologies that can influence criminal behavior (drugs possession/consumption and gender violence crimes). There are many standardized tests to evaluate and detect language difficulties in adults in English. However, there are relatively few options in Spanish; there are no tests that evaluate language qualitatively and in depth. Most of the research is conducted with children and adolescents.
    UNASSIGNED: To propose a reliable coding system for the correction and interpretation of narratives (essays and narratives) from the Battery for the Evaluation of Writing Processes (PROESC) in the prisoners charged of drugs possession or consumption and gender violence crimes.
    UNASSIGNED: The sample was composed of 287 men.
    UNASSIGNED: They completed the Demographic, Offense, and Behavioral Interview in Institutions, the International Personality Disorders Examination (IPDE), and PROESC.
    UNASSIGNED: We found that the proposed coding system presented high concordance, that is, high inter-rater reliability.
    UNASSIGNED: The classification system for the correction and interpretation of narratives was shown to be reliable.
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  • 文章类型: Journal Article
    双语语言产生理论预测,患有阿尔茨海默病(AD)的双语者应表现出两种下降模式之一。两种语言的并行下降(如果下降反映了对两种语言访问的语义表示的损害),或者不对称下降,非显性语言的下降幅度更大(如果下降反映出随着疾病进展解决显性语言竞争的能力下降)。之前只有两项研究检查了纵向下降,其中一项显示平行,另一种是不对称的,下降。我们检查了西班牙语-英语双语者(N=23)在2-7年内的下降(平均3.9)。Logistic回归显示,与基线相比,一年后呈平行下降模式,但在较长的衰退期内是不对称的衰退期,非显性语言的下降幅度更大(当计算正确反应的预测概率时)。仅当模型中包含项目难度时,非显性语言的不对称下降模式才明显更大。跨优势群体的探索性分析着眼于相对于初始命名准确性的比例下降,进一步表明,如果该语言是在以后的生活中获得的,则非优势语言的下降可能会更加陡峭。但在逻辑回归分析中,支持这种可能性所需的关键交互作用并无统计学意义.这些结果表明,非显性语言的可及性最初可能在早期相对于更晚期的AD更具弹性。并且在执行控制下降到在单语言测试块中命名图片的能力被中断之前,AD会影响共享的语义表示。需要做更多的工作来确定不对称的衰退模式是否会因非主导语言的晚期习得而被放大,如果执行控制的细微损害是AD最早阶段(甚至临床前)发生的语言转换损害的基础。
    Theories of bilingual language production predict that bilinguals with Alzheimer\'s disease (AD) should exhibit one of two decline patterns. Either parallel decline of both languages (if decline reflects damage to semantic representations that are accessed by both languages), or asymmetrical decline, with greater decline of the nondominant language (if decline reflects reduced ability to resolve competition from the dominant language with disease progression). Only two previous studies examined decline longitudinally with one showing parallel, and the other asymmetrical, decline. We examined decline over 2-7 years (3.9 on average) in Spanish-English bilinguals (N = 23). Logistic regression revealed a parallel decline pattern at one year from baseline, but an asymmetrical decline pattern over the longer decline period, with greater decline of the nondominant language (when calculating predicted probabilities of a correct response). The asymmetrical decline pattern was significantly greater for the nondominant language only when including item-difficulty in the model. Exploratory analyses across dominance groups looking at proportional decline relative to initial naming accuracy further suggested that decline of the nondominant language may be more precipitous if that language was acquired later in life, but the critical interaction needed to support this possibility was not statistically significant in a logistic regression analysis. These results suggest that accessibility of the nondominant language may initially be more resilient in early versus more advanced AD, and that AD affects shared semantic representations before executive control declines to a point where the ability to name pictures in single-language testing block is disrupted. Additional work is needed to determine if asymmetrical decline patterns are magnified by late age of acquisition of the nondominant language, and if more subtle impairments to executive control underlie impairments to language switching that occur in the earliest stages of AD (even preclinically).
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  • 文章类型: Journal Article
    Language disorders may interfere with social integration and affectpersonal development. Beca-use the balance of the stomatognathic system can interfere with language, it is important for speech therapy and dentistry to work together, providing multidisciplinar y Healthcare.
    To analyze the 100 most frequently cited articles on language disorders in children and adolescents and assess the interplay with dentistry by means of a bibliometric analysis.
    A search of the 100 most frequently cited articles up to December 2021 on language disorders was performed in the Web of Science Core Collection database. Four researchers extracted the data on number of citations, title, authors, country, year of publication, journals, study design, prevalent clinical conditions, and area of expertise. The analyses were performed using VOSviewer and Excel.
    The total number of citations ranged from 251 to 1,431. Four articles were cited more than 1,000 times. Bishop DVM (10 articles; 3,653 citations) and Tomblin JD (10 articles; 4,261 citations) were the most frequently cited authors. The institutions with the largest number of publications were the University of Oxford/England (11%) and the University of Kansas/USA (8%). Observational study design was the most frequent (77%). Autism spectrum disorder (18%) and dyslexia (14%) were the most broadly investigated clinical conditions. Speech-language pathology (32%) was the area of expertise with the largest number of articles, and none of the top 100 studies showed interplay with dentistry.
    The 100 most widely cited articles on language disorders are mostly observational, mainly address autism spectrum disorder, and are in the field of speech-language pathology No study reported interplay with dentistry.
    Os disturbios de linguagem podem interferir na integrando social e afetar o desenvolvimento dos individuos. O trabalho multidisciplinar entre fonoaudiologia e odontologia é muito importante para a promogdo da saúde. O equilibrio do sistema estomatognático interfere na linguagem.
    Analisar os100 artigos mais citados sobre distúrbios de linguagem em criannas e adolescentes e verificar a interando com a odontologia por meio de análise bibliométrica.
    Foi realizada uma busca pelos 100 artigos mais citados sobre distúrbios de linguagem na base de dados Web of Science Core Collection até dezembro de 2021. Quatro pesquisadores extrairam os dados referentes a número de citanoes, titulo, autores, país, ano de publicando, periódicos, desenho de estudo, condinoes clínicas prevalentes e área de especializando. As análises foram realizadas utilizando VOSviewer e Excel.
    O número total de citanoes variou de 251 a 1.431. Quatro artigos foram citados mais de 1.000 vezes. Bishop DVM (10 artigos; 3.653 citanoes) e Tomblin JD (10 artigos; 4.261 citanoes) foram os autores mais frequentemente citados. As instituinoes com maior número de publicanoes foram a Universidade de Oxford/Inglaterra (11%) e a Universidade de Kansas/EUA (8%). O desenho de estudo observacional foi o mais frequente (77%). O transtorno do espectro autista (18%) e a dislexia (14%) foram as condinoes clínicas mais amplamente investigadas. A Fonoaudiologia (32%) foi a área de atuando com maior número de artigos e nenhum estudo, entre os top100, mostrou interando com a Odontologia.
    Os 100 artigos mais citados sobre distúrbios de linguagem sdo em sua maioria observacionais, abordam principalmente transtornos do espectro do autismo e estdo na área de fonoaudiologia. Nenhum estudo apresentou interando com a odontologia.
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  • 文章类型: Journal Article
    目的:研究语言在阿尔茨海默病过程中是如何恶化的。
    方法:横截面,进行了观察性研究。通过波士顿诊断性失语症检查(BDAE)评估了使用NINCDS-ARDRA标准诊断为AD并接受治疗剂量乙酰胆碱酯酶抑制剂治疗AD的35例患者。样本包括15例轻度AD患者(MMSE>23,CDR=0或0.5-1.0)和20例中度AD患者(MMSE=13-23,CDR=2)。比较两组在所有语言任务上的结果。
    结果:在BDAE的总分方面,轻度和中度AD组之间存在统计学上的显着差异(95%CI47.10-114.08,t=5.0,DF=21,p=0.000*),以及涉及口头和书面理解的几项任务,语言口头表达和写作。
    结论:研究结果显示在中度阶段发生了重大变化。此外,语言表现的下降与痴呆综合征的恶化有关,独立于社会人口统计学变量。
    To investigate how language deteriorates over the Alzheimer\'s Disease course.
    A cross-sectional, observational study was carried out. 35 patients diagnosed with dementia due to AD using the NINCDS-ARDRA criteria and undergoing treatment for AD with a therapeutic dose of acetylcholinesterase inhibitors were assessed by the Boston Diagnostic Aphasia Examination (BDAE). The sample comprised 15 patients with mild AD (MMSE > 23, CDR = 0 or 0.5‒1.0) and 20 patients with moderate AD (MMSE = 13‒23, CDR = 2). The results for the 2 groups on all language tasks were compared.
    A statistically significant difference was found between the mild and moderate AD groups for total score on the BDAE (95% CI 47.10‒114.08, t = 5.0, DF = 21, p = 0.000*), as well as on several tasks involving oral and writing comprehension, language oral expression and writing.
    The study results showed major changes in the moderate stage. Also, the decline in language performance correlated with the worsening of dementia syndrome, independently of sociodemographic variables.
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  • 文章类型: Journal Article
    学生语言障碍中人格化滥用的患病率不断上升,这对自闭症学生在语言障碍领域构成了重大挑战。虽然先前的研究主要集中在自闭症学生面临的认知障碍上,关于发病的争论仍在继续,严重程度,这些挑战的根源在于他们的课堂行为,对先入为主的观念如何影响人格化滥用的探索有限。这项研究旨在深入研究语言障碍的情感治疗,专门针对人格化滥用,促进从扭曲的感知向规范表达的转变。它旨在查明与人格化滥用有关的主要情感干预措施,并审查影响语言障碍治疗方法的情感因素。
    这项研究涵盖了110名自闭症学生,2至5岁,被诊断为语言障碍,所有临床确定患有自闭症的发育儿科医生在一个著名的医疗机构。在这些孩子中,95人在专门学校上学,而15人位于社区环境中。
    结果显示,所有发育阶段的儿童在语言障碍中都表现出人格化滥用的情况,展示了情感治疗后人格化滥用方面值得注意的增强。重要的是,人格化虐待表现和情感治疗的明显差异可以与自闭症学生在四个年级的同时认知进步有关,根据规范表达式标注的变化。
    这些发现强调了在情感治疗背景下仅仅依靠内在趋势来理解人格化虐待的不足。该研究强调了与语言障碍的情感治疗相关的潜在陷阱,并强调迫切需要额外的研究和精神干预策略。
    UNASSIGNED: The escalating prevalence of personification abuse in language disorders among students poses a substantial challenge for autistic students in the domain of language disorders. While prior research has mainly focused on the cognitive hurdles faced by autistic students, ongoing debates persist about the onset, severity, and roots of these challenges in their classroom behavior, with limited exploration of how preconceived notions impact personification abuse. This study aims to delve into emotional treatments for language disorders, specifically targeting personification abuse, to facilitate the shift from distorted perceptions to normative expression. It seeks to pinpoint the primary emotional interventions linked to instances of personification abuse and scrutinize the emotional factors influencing therapeutic approaches for language disorders.
    UNASSIGNED: The research encompassed a cohort of 110 autistic students, aged 2 to 5 years, diagnosed with language disorders, all clinically determined to have autism by developmental pediatricians at a prestigious medical facility. Among these children, 95 were attending specialized schools, while 15 were situated in community settings.
    UNASSIGNED: The outcomes disclosed that children across all developmental phases displayed instances of personification abuse in language disorders, showcasing noteworthy enhancements in personification abuse following emotional treatment. Significantly, the discernible disparity in personification abuse performance and emotional treatment can be linked to the simultaneous cognitive advancement of autistic students across four grade levels, with variations noted based on normative expressions.
    UNASSIGNED: These findings underscore the insufficiency of solely relying on intrinsic trends to comprehend personification abuse within an emotional treatment context. The study accentuates the potential pitfalls associated with emotional treatment for language disorders and stresses the imperative need for additional research and psychiatric intervention strategies.
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  • 文章类型: Journal Article
    背景:经典发作性皮质基底综合征(CBS)患者表现为不对称肢体失用症和帕金森病。我们有,然而,观察到最初出现言语和/或语言(SL)问题并在几年后发展为CBS的患者(即,SL发作CBS)。我们的目的是比较临床,经典发作CBS与SL发作CBS的神经影像学和病理学特征。
    方法:我们对62例符合CBS标准的患者进行了回顾性队列研究(17例出现经典发作的CBS,45例出现SL发作的CBS)。我们比较了人口统计,临床特征,两组之间使用SPM12的灰质和白质体积丢失,并评估了死亡和尸检患者的病理学和皮质基底变性(CBD)病理学病变计数。
    结果:CBS诊断的中位年龄在经典发作的CBS中为66.4岁,在SL发作的CBS中为73.6岁。经典发作的CBS有更高的肌张力障碍频率,肌阵鸣,和外星肢体现象,而SL发作的CBS的垂直核上凝视麻痹的频率更高。两组的额顶体积均小于对照组,SL发作的CBS在左辅助运动区的体积损失比经典发作的CBS更大。所有3例尸检经典发作的CBS病例(100%)均具有CBD病理学,而8/21的SL发作的CBS病例(38%)具有CBD。经典发作和SL发作CBS之间的病理病变负担(包括星形细胞斑块)没有差异。
    结论:经典发作和SL发作的CBS似乎是不同的综合征,前者是一种更严重的运动综合征。SL发作CBS中更广泛的体积损失可能反映了更长的病程。
    BACKGROUND: Patients with classic-onset corticobasal syndrome (CBS) present with asymmetric limb apraxia and parkinsonism. We have, however, observed patients who initially present with speech and/or language (SL) problems and several years later develop CBS (i.e., SL-onset CBS). We aimed to compare clinical, neuroimaging and pathological characteristics of classic-onset CBS with SL-onset CBS.
    METHODS: We conducted a retrospective cohort study of 62 patients who met criteria for CBS (17 presented with classic-onset CBS and 45 had SL-onset CBS). We compared demographics, clinical characteristics, and grey and white matter volume loss with SPM12 between groups and assessed pathology and corticobasal degeneration (CBD) pathological lesion counts in patients who had died and undergone autopsy.
    RESULTS: Median age at CBS diagnosis was 66.4 years in classic-onset CBS and 73.6 years in SL-onset CBS. Classic-onset CBS had higher frequencies of dystonia, myoclonus, and alien limb phenomenon, while SL-onset CBS had a higher frequency of vertical supranuclear gaze palsy. Both groups showed smaller frontoparietal volumes than controls, with SL-onset CBS having greater volume loss in the left supplementary motor area than classic-onset CBS. All three classic-onset CBS cases with autopsy (100 %) had CBD pathology while 8/21 of SL-onset CBS cases (38 %) had CBD. Pathological lesion burden (including astrocytic plaques) did not differ between classic-onset and SL-onset CBS.
    CONCLUSIONS: Classic-onset and SL-onset CBS appear to be different syndromes, with the former being a more profuse motor syndrome. The more widespread volume loss in SL-onset CBS likely reflects longer disease course.
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  • 文章类型: Journal Article
    评价孕期或婴儿早期使用抗生素与儿童神经发育障碍风险之间的关系。
    基于全国人群的队列研究和兄弟姐妹分析。
    韩国国民健康保险服务母子关联数据库,2008-21.
    所有出生在2009年至2020年之间的儿童,随访至2021年,以比较在怀孕或婴儿早期(生命的前六个月)期间有和没有抗生素暴露的儿童。
    自闭症谱系障碍,智力障碍,语言障碍,儿童癫痫。在基于许多潜在混杂因素的1:1倾向评分匹配后,使用Cox比例风险模型估计具有95%置信区间的风险比.兄弟姐妹分析还考虑了未测量的家族因素。
    倾向得分匹配后,1961744名儿童被确定用于妊娠分析,1609774名儿童被确定用于早期婴儿期分析。尽管在整个队列中,怀孕期间的抗生素暴露与所有四种神经发育障碍的风险增加有关,在同胞分析中,这些估计值朝向零值衰减(自闭症谱系障碍的风险比1.06,95%置信区间1.01~1.12;智力障碍1.00,0.93~1.07;语言障碍1.05,1.02~1.09;癫痫1.03,0.98~1.08).同样,未观察到婴儿早期抗生素暴露与自闭症谱系障碍之间的关联(风险比1.00,0.96至1.03),智力障碍(1.07,0.98至1.15),兄弟姐妹分析中的语言障碍(1.04、1.00至1.08);然而,观察到癫痫的风险略有增加(1.13,1.09~1.18).在几个亚组和敏感性分析中,结果总体上保持一致,除了在生命早期使用抗生素的儿童和使用抗生素超过15天的儿童中观察到的风险略有升高。
    在这项大型队列研究中,怀孕或婴儿早期接触抗生素与自闭症谱系障碍的风险增加无关,智力障碍,或儿童语言障碍。然而,在几个亚组中观察到风险升高,例如在生命早期使用抗生素的儿童和长期使用抗生素的儿童,值得关注和进一步调查。此外,婴儿期使用抗生素与癫痫有一定的相关性,即使在控制适应症和家族因素之后。给孕妇和婴儿开抗生素时,临床医生应仔细平衡使用的益处和潜在的风险.
    To evaluate the association between antibiotic use during pregnancy or early infancy and the risk of neurodevelopmental disorders in children.
    Nationwide population based cohort study and sibling analysis.
    Korea\'s National Health Insurance Service mother-child linked database, 2008-21.
    All children live born between 2009 and 2020, followed up until 2021 to compare those with and without antibiotic exposure during pregnancy or early infancy (first six months of life).
    Autism spectrum disorder, intellectual disorder, language disorder, and epilepsy in children. After 1:1 propensity score matching based on many potential confounders, hazard ratios with 95% confidence interval were estimated using Cox proportional hazard models. A sibling analysis additionally accounted for unmeasured familial factors.
    After propensity score matching, 1 961 744 children were identified for the pregnancy analysis and 1 609 774 children were identified for the early infancy analysis. Although antibiotic exposure during pregnancy was associated with increased risks of all four neurodevelopmental disorders in the overall cohort, these estimates were attenuated towards the null in the sibling analyses (hazard ratio for autism spectrum disorder 1.06, 95% confidence interval 1.01 to 1.12; intellectual disorder 1.00, 0.93 to 1.07; language disorder 1.05, 1.02 to 1.09; and epilepsy 1.03, 0.98 to 1.08). Likewise, no association was observed between antibiotic exposure during early infancy and autism spectrum disorder (hazard ratio 1.00, 0.96 to 1.03), intellectual disorder (1.07, 0.98 to 1.15), and language disorder (1.04, 1.00 to 1.08) in the sibling analyses; however, a small increased risk of epilepsy was observed (1.13, 1.09 to 1.18). The results generally remained consistent across several subgroup and sensitivity analyses, except for slightly elevated risks observed among children who used antibiotics during very early life and those who used antibiotics for more than 15 days.
    In this large cohort study, antibiotic exposure during pregnancy or early infancy was not associated with an increased risk of autism spectrum disorder, intellectual disorder, or language disorder in children. However, elevated risks were observed in several subgroups such as children using antibiotics during very early life and those with long term antibiotic use, which warrants attention and further investigation. Moreover, antibiotic use during infancy was modestly associated with epilepsy, even after control for indications and familial factors. When prescribing antibiotics to pregnant women and infants, clinicians should carefully balance the benefits of use against potential risks.
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  • 文章类型: Observational Study
    背景:这项研究旨在通过观察和孟德尔随机化(MR)设计,彻底研究先天性心脏病(CHD)与神经发育障碍(NDD)之间的联系。
    方法:这项观察性研究使用了全国儿童健康调查(2020-2021年)的数据。采用多变量logistic回归和倾向评分匹配(PSM)进行关联分析。PSM用于最小化协变量的偏差,如年龄,种族,性别,产妇年龄,出生体重,脑震荡或脑损伤,早产,脑瘫,唐氏综合症,和其他遗传条件。在MR分析中,方差加权逆度量,加权中位数,和MR-Egger用于计算因果效应。
    结果:本研究共分析了85,314名0-17岁儿童。在回归分析中,CHD(p=0.04),当前的心脏状况(p=0.03),当前心脏病的严重程度(p<0.05)与言语或语言障碍有暗示性关联。当前心脏病的严重程度(p=0.08)与注意缺陷多动障碍(ADHD)具有潜在的统计学显着关联。在PSM样本中,多动症(p=0.003),智力残疾(p=0.012),言语或语言障碍(p<0.001)均与冠心病显著相关。当前心脏病的严重程度(p<0.001)也与自闭症有显著关联。MR分析未发现遗传代理的先天性心脏畸形与NDD风险之间的因果关系。
    结论:我们的研究表明,冠心病患儿发生NDD的风险增加。当前的心脏状况和当前心脏状况的严重程度也与这些NDD显著相关。在未来,我们需要尝试更多的方法来阐明CHD与NDD之间的因果关系。
    BACKGROUND: This study aims to thoroughly study the connection between congenital heart disease (CHD) and neurodevelopmental disorders (NDDs) through observational and Mendelian randomization (MR) designs.
    METHODS: This observational study uses data from the National Survey of Children\'s Health (2020-2021). Multivariable logistic regression and propensity score matching (PSM) were performed to analyze the association. PSM was used to minimize bias for covariates such as age, race, gender, maternal age, birth weight, concussion or brain injury, preterm birth, cerebral palsy, Down syndrome, and other inherited conditions. In MR analyses, inverse variance-weighted measures, weighted median, and MR-Egger were employed to calculate causal effects.
    RESULTS: A total of 85,314 children aged 0-17 were analyzed in this study. In regression analysis, CHD (p = 0.04), the current heart condition (p = 0.03), and the severity of current heart condition (p < 0.05) had a suggestive association with speech or language disorders. The severity of current heart condition (p = 0.08) has a potential statistically significant association with attention deficit hyperactivity disorder(ADHD). In PSM samples, ADHD(p = 0.003), intellectual disability(p = 0.012), and speech or language disorders(p < 0.001) were all significantly associated with CHD. The severity of current heart condition (p < 0.001) also had a significant association with autism. MR analysis did not find causality between genetically proxied congenital cardiac malformations and the risk of NDDs.
    CONCLUSIONS: Our study shows that children with CHD have an increased risk of developing NDDs. Heart conditions currently and severity of current heart conditions were also significantly associated with these NDDs. In the future, we need to try more methods to clarify the causal relationship between CHD and NDDs.
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  • 文章类型: Journal Article
    目的:本研究的目的是探讨语言功能磁共振成像(fMRI)引导的纤维束成像与颞叶癫痫(TLE)患者术后命名下降的关系。
    方法:对20例单侧TLE患者(左9例)进行了听觉和图片命名功能MRI研究。左后叶颞叶的激活最大值用作全脑纤维束造影的种子区域。术前评估临床命名性能,4个月,颞叶切除后12个月。使用Pearson相关性和与其他临床变量的多元线性回归,探索了两个半球的白质语言束体积以及束体积侧向性指数作为术后命名下降的调节因子。
    结果:在后续手术的半球中,来自听觉和图片命名最大值的大量白质语言束,以及图片命名束体积到手术侧的更强的侧向化与更大的语言衰退相关。这与fMRI侧化状态无关。在短期和长期随访中,图片命名道体积的多元回归与命名功能的显着下降有关,敏感性为100%,特异性为93%。
    结论:命名fMRI引导的白质语言道体积与TLE患者颞叶切除术后命名下降有关。这可以帮助对手术结果进行分层,并最大程度地减少TLE术后语言障碍的风险。
    OBJECTIVE: The aim of this study was to explore the relation of language functional MRI (fMRI)-guided tractography with postsurgical naming decline in people with temporal lobe epilepsy (TLE).
    METHODS: Twenty patients with unilateral TLE (9 left) were studied with auditory and picture naming functional MRI tasks. Activation maxima in the left posterobasal temporal lobe were used as seed regions for whole-brain fibre tractography. Clinical naming performance was assessed preoperatively, 4 months, and 12 months following temporal lobe resection. Volumes of white matter language tracts in both hemispheres as well as tract volume laterality indices were explored as moderators of postoperative naming decline using Pearson correlations and multiple linear regression with other clinical variables.
    RESULTS: Larger volumes of white matter language tracts derived from auditory and picture naming maxima in the hemisphere of subsequent surgery as well as stronger lateralization of picture naming tract volumes to the side of surgery correlated with greater language decline, which was independent of fMRI lateralization status. Multiple regression for picture naming tract volumes was associated with a significant decline of naming function with 100% sensitivity and 93% specificity at both short-term and long-term follow-up.
    CONCLUSIONS: Naming fMRI-guided white matter language tract volumes relate to postoperative naming decline after temporal lobe resection in people with TLE. This can assist stratification of surgical outcome and minimize risk of postoperative language deficits in TLE.
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