functional movement disorder

功能性运动障碍
  • 文章类型: Journal Article
    据推测,异常的感觉过程有助于功能性神经系统疾病的病理生理学,尽管调查结果不一致。这里,我们利用功能磁共振成像(fMRI)检查了功能性运动障碍(FMD)中感知式注意-意识焦点和身体感觉意识的神经相关性.
    我们使用逐体素分析来比较13名患有多动性口蹄疫的成年人和13名健康对照(HC)在一项需要注意不同身体感觉和外在感受刺激的任务期间的血氧水平依赖性反应。此外,我们检查了组间自我报告的相互感觉测量值的差异,并评估了它们与神经活动的关系.
    互感状况(心跳,胃和“身体”,指示FMD参与者受影响的身体部位或肢体的感觉)激活了涉及前突的网络,后扣带皮质(PCC)和尾状核(CN)两侧,和右前脑岛(aINS)(p<0.05,更正)。大脑活动的群体差异主要是由疾病相关的感受信号的处理驱动的,在FMD组中,与监测胃内感觉相比,它与更广泛的神经激活有关,而在心脏间感觉期间未检测到组差异。在PCC中发现了FMD受试者和HCs之间基于相互感觉焦点(身体与心跳和胃)的差异,CN,角回,丘脑,和中岛(p<0.05,校正)。
    这是,根据我们的知识,第一项研究表明,口蹄疫与参与监测身体状态的区域的异常交互感受处理有关,注意力集中,和稳态推理。
    UNASSIGNED: Aberrant interoceptive processing has been hypothesized to contribute to the pathophysiology of functional neurological disorder, although findings have been inconsistent. Here, we utilized functional magnetic resonance imaging (fMRI) to examine neural correlates of interoceptive attention - the conscious focus and awareness of bodily sensations - in functional movement disorder (FMD).
    UNASSIGNED: We used voxelwise analyses to compare blood oxygenation level-dependent responses between 13 adults with hyperkinetic FMD and 13 healthy controls (HCs) during a task requiring attention to different bodily sensations and to an exteroceptive stimulus. Additionally, we examined between-group differences in self-reported measures of interoception and evaluated their relationship with neural activity.
    UNASSIGNED: Interoceptive conditions (heartbeat, stomach and \'body\', indicating sensations from the body part or limb affected in FMD participants) activated a network involving the precuneus, the posterior cingulate cortex (PCC) and caudate nucleus (CN) bilaterally, and the right anterior insula (aINS) (p <0.05, corrected). Group differences in brain activity were mainly driven by processing of disease-related interoceptive signals, which in the FMD group was associated with a broader neural activation than monitoring gastric interoception, while no group differences were detected during cardiac interoception. Differences based on interoceptive focus (body vs heartbeat and stomach) between FMD subjects and HCs were found in PCC, CN, angular gyrus, thalamus, and in the mid-insula (p <0.05, corrected).
    UNASSIGNED: This is, to our knowledge, the first study showing that FMD is associated with abnormal interoceptive processing in regions involved in monitoring body state, attentional focus, and homeostatic inference.
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  • 文章类型: Journal Article
    目的:外周诱发的运动障碍(PIMD)是运动过度的运动障碍,可在身体一部分受伤后发生。这项研究旨在识别牙科或口腔外科手术后的口颌系统中的PIMD。
    方法:回顾性评估了229例因口腔手术或牙科介入引发的PIMD患者(144名女性和85名男性;平均年龄:53.4岁)。
    结果:手术与PIMD发病之间的平均潜伏期为14.3天。口腔外科(40.2%),包括拔牙,创伤治疗,和其他外科手术,是PIMD最常见的触发因素。随后是一般的牙科治疗,包括牙周,牙髓,和恢复性程序(36.7%),修复治疗(19.7%),和正畸治疗(3.5%)。PIMD包括口下颌肌张力障碍(73.8%),功能性(心因性)运动障碍(11.4%),口舌型运动障碍(7.9%),和半磁性痉挛(5.7%)。
    结论:这些结果表明,即使是牙科手术后正常解剖或生理上的微小改变,也可能导致易感患者发生PIMD。
    结论:牙科专业人员应该意识到,尽管很少,PIMD可以在各种牙科治疗后发展。如果出现这样的症状,主治医师应向患者适当解释,并向运动障碍专家提供适当的治疗或咨询。
    OBJECTIVE: Peripherally induced movement disorders (PIMD) are hyperkinetic movement disorders that can occur after injury to a part of the body. This study aimed to identify PIMD in the stomatognathic system following dental or oral surgical procedures.
    METHODS: A total of 229 patients with PIMD (144 women and 85 men; mean age: 53.4 years) triggered by oral surgical or dental interventions were evaluated retrospectively.
    RESULTS: The average latency between the procedures and onset of PIMD was 14.3 days. Oral surgery (40.2%), including tooth extraction, trauma treatment, and other surgical procedures, was the most frequent trigger of PIMD. This was followed by general dental treatment, including periodontal, endodontic, and restorative procedures (36.7%), prosthetic treatment (19.7%), and orthodontic treatment (3.5%). PIMD consisted of oromandibular dystonia (73.8%), functional (psychogenic) movement disorders (11.4%), orolingual dyskinesia (7.9%), and hemimasticatory spasms (5.7%).
    CONCLUSIONS: These results suggest that even minor alterations in normal anatomy or physiology after dental procedures may result in PIMD in predisposing patients.
    CONCLUSIONS: Dental professionals should be aware that although infrequently, PIMD can develop after various dental treatments. If such symptoms precipitate, the attending physician should properly explain them to the patient and provide appropriate treatment or consultation with a movement disorder specialist.
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  • 文章类型: Journal Article
    从2019年开始,德国首次爆发了由社交媒体引起的大规模社会疾病(大众社交媒体诱发的疾病;MSMI),表现为功能性Tourette样行为(FTB)。这项研究旨在提供2019年至2021年德国普通人群MSMI-FTB患病率的初步数据。我们与USUMA市场和社会研究所合作进行了大规模的代表性人口调查。2021年8月至12月,n=2.509人(平均年龄:49.5岁,范围:16-95年,n=1.276女性)被随机选择,拜访他们的家庭,采访,并要求自己回答,也适用于亲密的家庭成员(n=6.744)。因此,总的来说,我们收到了n=9.253人的答案。在n=33个人中发现了可能的MSMI-FTB(平均年龄:30.5岁,n=8个女性)。基于严格的标准,MSMI-FTB的诊断被认为在16/33个体中很可能(发病时的平均年龄:25.6岁,n=2女性),对应于0.17%(CIlower=0.10,CI上限=0.28)和0.36%(CIlower=0.25,CI上限=0.50)的患病率,分别。这是第一次大规模,人口代表性研究调查了2019年至2021年德国普通人群MSMI-FTB的患病率。根据发现的患病率,MSMI-FTB与卫生经济高度相关。因此,我们建议教育医疗保健专业人员和公众,以避免误诊和低效的治疗。
    Starting in 2019, in Germany the first well documented outbreak of mass sociogenic illness induced by social media (mass social media-induced illness; MSMI) occurred presenting with functional Tourette-like behaviors (FTB). This study aimed to provide first data on the prevalence rate of MSMI-FTB in Germany between 2019 and 2021 in the general population. We conducted a large-scale representative population survey in cooperation with the USUMA market and social research institute. Between August and December 2021, n = 2.509 people (mean age: 49.5 years, range: 16-95 years, n = 1.276 females) were randomly selected, visited in their households, interviewed, and asked to answer for themselves, but also for close family members (n = 6.744). Thus, in total, we received answers for n = 9.253 people. Probable MSMI-FTB was found in n = 33 individuals (mean age at onset: 30.5 years, n = 8 females). Based on strict criteria, the diagnosis of MSMI-FTB was considered highly likely in 16/33 individuals (mean age at onset: 25.6 years, n = 2 females) corresponding to prevalence rates of 0.17% (CIlower = 0.10, CIupper = 0.28) and 0.36% (CIlower = 0.25, CIupper = 0.50), respectively. This is the first large-scale, population representative study investigating the prevalence of MSMI-FTB in the general population in Germany between 2019 and 2021. Based on the prevalence rates found, MSMI-FTB is highly relevant for health economy. Accordingly, we suggest educating healthcare professionals and the general public to avoid misdiagnosis and inefficient treatment.
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  • 文章类型: Case Reports
    在这里,我们描述了一名55岁的女性患者,患有功能性运动障碍(FMD),并表现为正常压力性脑积水(NPH)样诊所。神经成像数据和对敲击测试的阳性反应最初表明NPH。然而,对临床特征的详细调查得出了FMD的最终诊断.通过这个病人的介绍,我们扩展了口蹄疫的现象学。据我们所知,这是首次出现模仿NPH的FMD患者.因此,我们认为这个罕见的例子很有趣,可能为临床实践提供有价值的观点。
    Herein, we describe a 55-year-old female patient with a functional movement disorder (FMD) who presented with normal pressure hydrocephalus (NPH)-like clinic. The neuroimaging data and positive response to the tap test initially suggested NPH. However, a detailed investigation of the clinic features yielded a final diagnosis of FMD. Via the presentation of this patient, we expand the phenomenology of FMD. To our knowledge, this is the first presentation of a patient with FMD mimicking NPH. Therefore, we think this rare illustration is interesting and may provide valuable perspectives for clinical practice.
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  • 文章类型: Journal Article
    功能性运动障碍(FMD)是一种常见的功能性神经障碍(FND),但往往难以诊断或管理。口蹄疫可以表现为各种表型,包括震颤,肌张力障碍,肌阵鸣,步态障碍和帕金森病。进行适合评估疑似口蹄疫患者的临床检查很重要,和各种诊断测试操作也可能是有帮助的。涉及多学科团队的治疗,门诊或住院,被发现是最有效的。本文还讨论了此类治疗方案的示例。虽然在过去的几十年里,人们对这种疾病的认识和理解似乎有所改善,以及治疗方法的发展,患者和医生在治疗这种疾病时继续遇到各种困难并不少见。在这次审查中,我提供了FMD的实用概述,并讨论了临床遇到本身如何在患者接受诊断中发挥作用。还讨论了最近的神经影像学研究的更新,这些研究有助于理解病理生理学。
    Functional movement disorder (FMD) is a type of functional neurological disorder that is common but often difficult to diagnose or manage. FMD can present as various phenotypes, including tremor, dystonia, myoclonus, gait disorders, and parkinsonism. Conducting a clinical examination appropriate for assessing a patient with suspected FMD is important, and various diagnostic testing maneuvers may also be helpful. Treatment involving a multidisciplinary team, either outpatient or inpatient, has been found to be most effective. Examples of such treatment protocols are also discussed in this review. While recognition and understanding of the disorder has improved over the past few decades, as well as the development of treatments, it is not uncommon for patients and physicians to continue to experience various difficulties when dealing with this disorder. In this review, I provide a practical overview of FMD and discuss how the clinical encounter itself can play a role in patients\' acceptance of the diagnosis. Recent neuroimaging studies that aid in understanding the pathophysiology are also discussed.
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  • 文章类型: Case Reports
    关于功能性运动障碍的专科物理治疗的信息很少。以前的研究集中在功能性步态障碍上,对实际应用的描述特别是对其他身体区域的描述非常有限。
    我们给出了两个说明性的案例,展示了除了步态困难之外的功能性运动障碍的物理治疗的关键要素。物理治疗的具体核心要素的个体适用性,适应每个患者的个人需求,被描述。我们也解释,如何使用不同的感官刺激将注意力从症状转移到减少症状。此外,我们讨论如何鼓励患者的机构,以及如何在治疗的关键时刻,有助于症状的持续改善。
    因此,我们的病例系列旨在指导临床医生和治疗师,促进这种常见和可治疗的神经精神疾病的疾病特异性物理治疗。
    UNASSIGNED: Information on specialist physiotherapeutic treatment for functional movement disorders is scarce. Previous studies focussed on functional gait disorders and availability of descriptions of the practical application especially for other body regions is very limited.
    UNASSIGNED: We present two illustrative cases, demonstrating the key elements of physiotherapy for the treatment of functional movement disorders beyond gait difficulties. The individual applicability of the specific core elements of physiotherapy, adapted to the individual needs of each patient, are described. We also explain, how different sensory stimuli can be used to shift attention away from symptoms and thus reduce them. Moreover, we discuss how patients\' agency can be encouraged and how this results in therapy key moments, contributing to a sustained improvement of symptoms.
    UNASSIGNED: Thus, our case series are intended to guide clinicians and therapists alike, to promote disease-specific physiotherapy for this common and treatable neuropsychiatric disorder.
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  • 文章类型: Case Reports
    手部受伤通常表现为局部症状。然而,我们报告了一例不寻常的病例,一例32岁女性,她的整个左非优势手在第三掌骨和第四掌骨之间有1厘米的轻微刺伤后,出现了短暂的感觉和运动功能完全丧失.局部麻醉下探查伤口未见肌腱,血管,神经,或者骨伤。值得注意的是,她在受伤后120分钟内自发恢复了全部的手部感觉和功能。广泛的神经系统评估,包括磁共振成像(MRI),肌电图(EMG),神经传导研究(NCS),和体感诱发电位(SSEP),排除了器质性病理学,并支持功能性神经障碍(FND)的诊断,特别是功能性运动障碍(FMD)。手外科医生之间的密切合作,神经学家,职业治疗师对于准确的诊断和适当的多学科管理至关重要。需要进一步的研究来阐明FND的潜在机制,并在手外伤的背景下优化FND的循证治疗。在手外伤管理中涉及的专业中提高对这种情况的认识对于促进及时诊断和避免不必要的干预至关重要。
    Hand injuries typically present with localized symptoms. However, we report an unusual case of a 32-year-old female who experienced a transient complete loss of sensation and motor function in her entire left nondominant hand after sustaining a minor 1 cm stab wound between the third and fourth metacarpals. Wound exploration under local anesthesia revealed no tendon, vascular, neural, or bony injury. Remarkably, she spontaneously regained full hand sensation and function within 120 minutes of the injury. Extensive neurological evaluation, including magnetic resonance imaging (MRI), electromyography (EMG), nerve conduction studies (NCS), and somatosensory evoked potentials (SSEPs), ruled out organic pathology and supported a diagnosis of functional neurological disorder (FND), specifically functional movement disorder (FMD). Close collaboration between hand surgeons, neurologists, and occupational therapists is essential for accurate diagnosis and appropriate multidisciplinary management. Further research is needed to elucidate the mechanisms underlying FND and optimize evidence-based treatment for FND in the context of hand trauma. The increased awareness of this condition across specialties involved in hand injury management is crucial to facilitate timely diagnosis and avoid unnecessary interventions.
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  • 文章类型: Journal Article
    背景:功能性神经症状障碍(FND)的特征在于与公认的神经或医学病症不相容的神经症状。这种情况在神经科诊所很常见,会导致严重的发病率,虽然及时获得专科护理是困难的。我们试图描述澳大利亚和新西兰专业FND诊所的可用性和临床实践。
    方法:通过临床接触,通过雪球采样和联系患者组织进一步招募,确定了参与运营FND专科诊所的临床医生或协调员。所有诊所都完成了一项关于服务交付细节的调查,包括临床模型,转介来源,标准,需求,人员配备,干预措施,临床数据收集,和资金。
    结果:我们在澳大利亚和新西兰确定了16家诊所。其中,12个在首都,4个在区域中心。其中3例集中于儿科患者,13例集中于成年人。诊所的临床模型各不相同,转介来源,标准,人员配备,干预措施,数据收集,和资金。大多数诊所报告了与应对需求和获得足够资金有关的挑战。
    结论:澳大利亚和新西兰的FND诊所似乎主要集中在大都市地区,其转诊来源差异很大,临床数据收集,和护理模式。报告的满足需求方面的挑战表明需要更多的资源。诊所间的异质性表明,需要协调临床标准,以促进获得循证护理。
    BACKGROUND: Functional neurological symptom disorder (FND) is characterised by neurological symptoms that are incompatible with recognised neurological or medical conditions. The condition is common in neurology clinics and causes significant morbidity, though timely access to specialist care is difficult. We sought to characterise the availability and clinical practice of specialist FND clinics across Australia and New Zealand.
    METHODS: Clinicians or coordinators involved in running specialist FND clinics were identified through clinical contacts with further recruitment by snowball sampling and contacting patient organisations. All clinics completed a survey about details of service delivery, including clinical model, referral sources, criteria, demand, staffing, interventions, clinical data collection, and funding.
    RESULTS: We identified 16 clinics across Australia and New Zealand. Of these, 12 were in capital cities and four were in regional centres. Three of these focused on paediatric patients and 13 focused on adults. Clinics varied in their clinical model, referral sources, criteria, staffing, interventions, data collection, and funding. Most clinics reported challenges related to coping with demand and obtaining adequate funding.
    CONCLUSIONS: FND clinics in Australia and New Zealand appear to be concentrated predominantly in metropolitan areas and vary considerably in their referral sources, clinical data collection, and models of care. Reported challenges in meeting demand indicate a need for greater resources. The heterogeneity across clinics suggests a need to harmonise clinical standards to facilitate access to evidence-based care.
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  • 文章类型: Journal Article
    功能性运动障碍(FMD)和功能性癫痫(FS)是功能性神经系统疾病(FND)的两个最重要的子类别。
    本研究旨在辨别FMD和FS患者之间的异同。
    对94例FND患者(FMD=47,FS=47)进行了前瞻性比较研究。
    在FMD和FS患者中观察到的最常见的亚型是具有保留反应性的震颤和pauci动力学发作,分别。FMD患者的数量显着增加了一个以上的诱发因素(P=0.03)。头痛在FS患者中更为常见(P=0.03)。FMD组患者更多(P=0.01)。FS组中更多的患者报告“非常大的改善”(P=0.04),FMD组患者更常报告“无变化”(P=0.009)。
    情绪应激是FMD和FS患者最常见的诱发因素。FS患者预后较好。
    UNASSIGNED: Functional movement disorders (FMDs) and functional seizure (FS) are the two most important subcategories of functional neurologic disorders (FNDs).
    UNASSIGNED: This study aimed to discern similarities and differences between patients with FMD and FS.
    UNASSIGNED: A prospective comparative study of 94 patients with FNDs (FMD = 47, FS = 47) was conducted.
    UNASSIGNED: Tremor and pauci-kinetic attack with preserved responsiveness were the most common subtypes observed in patients with FMD and FS, respectively. A significantly higher number of patients with FMD had more than one precipitating factor (P = 0.03). Headache was significantly more common in patients with FS (P = 0.03). More patients came for follow-up in the FMD group (P = 0.01). More patients in the FS group reported \"very much improvement\" (P = 0.04), and \"no change\" was more commonly reported by the FMD group patients (P = 0.009).
    UNASSIGNED: Emotional stress was the most common precipitating factor in patients with FMD and FS. The prognosis was better in patients with FS.
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  • 文章类型: Journal Article
    功能性抽动样行为(FTLB)是一种女性主要的功能性神经系统疾病,在SARSCoV2大流行期间发病率上升。这项研究比较了社会和适应性功能,社交媒体使用,大流行经历,和FTLB之间的精神病合并症(n=35),Tourette综合征(TS)(n=22),和神经典型(NT)(n=25)参与者年龄11至25岁。FTLB参与者的精神病共病负担是巨大的,与TS和NT参与者相比,重度抑郁障碍和惊恐障碍的频率高1.5到10倍。边缘性人格障碍(BPD),广场恐惧症,社交焦虑障碍,与NT参与者相比,FTLB中广泛性焦虑障碍也明显更常见。脆弱的依恋分数,FTLB患者的社交恐惧症和社交互动焦虑症状高于NT,而TS患者则不高于NT.整体的遇险容忍度,有弹性的应对,可暗示性,在社交媒体上,暴露于抽动和TS含量在组间没有显着差异。FTLB参与者对他们在大流行期间的心理健康下降比TS和NT参与者更严重,并且更有可能经历睡眠困难,孤独,与新界参与者相比,难以提供住房和食物。与TS和NT相比,FTLB参与者更有可能确定为性别少数群体,尽管FTLB组中研究变量的性别认同没有显着差异。关联和潜在的途径解释了精神疾病如何可能导致FTLB,以及为什么某些群体出现在特定的风险进行了讨论。
    Functional tic-like behaviours (FTLB) are a female predominant functional neurological disorder that escalated in incidence during the SARS CoV2 pandemic. This study compared social and adaptive functioning, social media use, pandemic experiences, and psychiatric comorbidities between FTLB (n = 35), Tourette Syndrome (TS) (n = 22), and neurotypical (NT) (n = 25) participants ages 11 to 25 years. The psychiatric comorbidity burden for participants with FTLB was formidable, with frequencies ranging from 1.5 to 10 times higher for major depressive disorder and panic disorder compared to TS and NT participants. Borderline personality disorder (BPD), agoraphobia, social anxiety disorder, and generalized anxiety disorder were also significantly more common in FTLB compared to NT participants. Vulnerable attachment scores, social phobia and social interaction anxiety symptoms were higher in participants with FTLB than NT but not TS. Overall distress tolerance, resilient coping, suggestibility, hours on social media, and exposure to tic and TS content were not significantly different between groups. FTLB participants rated their mental health declined more severely during the pandemic than both TS and NT participants and were more likely to experience trouble sleeping, loneliness, and difficulty affording housing and food than NT participants. Participants with FTLB were significantly more likely to identify as gender minority people than TS and NT, though there were no significant differences based on gender identity in the study variables within the FTLB group. The association and potential pathways explaining how psychiatric disorders may be contributing to FTLB, and why certain groups appear at particular risk are discussed.
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