■功能性运动障碍(FMD)与精神病合并症的高患病率相关。
■评估口蹄疫中强迫症状(OCS)的频率。
■共有167例临床明确的口蹄疫患者(平均年龄=44.4岁,标准差[SD]=12.0,119名女性)和145名健康对照(平均年龄=43.2岁,SD=11.8,103名女性)完成了强迫性量表修订(OCI-R),这是一个广泛使用的工具,用于评估OCS。截止分数≥21表示有临床意义的强迫症(OCD)。使用简化FMD评定量表(S-FMDRS)评估运动症状的严重程度。所有受试者都完成了抑郁症调查问卷,焦虑,疼痛,疲劳,认知抱怨,与健康相关的生活质量,童年的创伤。使用大五问卷评估人格特征。
■口蹄疫患者的平均OCI-R评分较高,OCI-R≥2142%的个体比例较高,95%置信区间(CI)=(30.2,54.6)与16%,95%CI=(8.2,28.2),P<0.001。患者在三个领域得分较高:检查,ordering,和痴迷(P<0.001)。OCI-R评分≥21分的FMD患者抑郁情绪较高,焦虑,认知抱怨,与得分<21的人相比,生活质量较低(P<0.001)。OCI-R与S-FMDRS评分无相关性。
■口蹄疫患者报告的OCS发生率高于对照组,伴随着较高的非运动症状和较低的生活质量。这一发现可能具有临床意义,并提高了FMD和OCD共同危险因素和共同病理生理机制的可能性。
UNASSIGNED: Functional movement disorders (FMD) are associated with a high prevalence of psychiatric comorbidities.
UNASSIGNED: To assess the frequency of obsessive-compulsive symptoms (OCS) in FMD.
UNASSIGNED: A total of 167 consecutive patients with clinically definite FMD (mean age = 44.4 years, standard deviation [SD] = 12.0, 119 females) and 145 healthy controls (mean age = 43.2 years, SD = 11.8, 103 females) completed the Obsessive-Compulsive Inventory-Revised (OCI-R), which is a widely used tool for assessing OCS. The cutoff score ≥21 is indicative of clinically significant obsessive-compulsive disorder (OCD). Motor symptom severity was assessed using the Simplified FMD Rating Scale (S-FMDRS). All subjects completed questionnaires for depression, anxiety, pain, fatigue, cognitive complaints, health-related quality of life, and childhood trauma. Personality traits were assessed using the Big Five questionnaire.
UNASSIGNED: FMD patients had higher mean OCI-R score and higher proportion of individuals with OCI-R ≥ 21 42%, 95% confidence interval (CI) = (30.2, 54.6) versus 16%, 95% CI = (8.2, 28.2) in controls, P < 0.001. Patients had higher scores in three domains: checking, ordering, and obsessing (P < 0.001). FMD patients with OCI-R score ≥21 had higher depression, anxiety, cognitive complaints, and lower quality of life compared to those with score <21 (P < 0.001). No correlation between OCI-R and S-FMDRS scores was found.
UNASSIGNED: FMD patients reported higher rates of OCS compared to controls, along with higher rates of non-motor symptoms and lower quality of life. This finding may have clinical implications and raises the possibility of shared risk factors and common pathophysiological mechanisms in FMD and OCD.