目的:腓骨(腓骨)神经病是下肢最常见的单神经病。尽管如此,令人惊讶的是,关于这个主题的研究很少,文献中仍然存在知识差距。当人们试图解决这一知识差距时,需要一个核心结果集(COS)来指导未来研究的规划阶段,以实现这些研究的综合和可比性.这项研究的目的是使用改良的Delphi方法开发COS常见腓骨神经病(CoPe)。
方法:使用5阶段方法来开发COS-CoPe:1)阶段1,联盟开发;2)阶段2,文献综述,以确定潜在的结果指标;3)阶段3,Delphi调查,以就纳入结果达成共识;4)阶段4,Delphi调查,以制定定义;5)阶段5,共识会议,以最终确定COS和定义。该研究遵循了COS-STAndards促进发展(COS-STAD)的建议。
结果:神经外科(硬币)联盟的核心成果包括23名参与者,所有的神经外科医生,代表13个国家。最终的COS-CoPe由31个数据点/结果组成,涵盖人口统计学领域,诊断,患者报告的结果,运动/感觉结果,和并发症。适当的工具,测试方法,并设定了定义。共识最短随访时间为12个月。评估的最佳时间点是术前和术后3、6、12和24个月。
结论:硬币联盟制定了共识COS并提供了定义,实施方法,和评估的时间点。COS-CoPe应作为最小的数据集,应在所有未来的神经外科研究中收集常见的腓骨神经病。合并此COS应有助于提高报告的一致性,数据合成,和可比性,并应尽量减少结果报告偏差。
OBJECTIVE: Common peroneal (fibular) neuropathy is the most common mononeuropathy of the lower extremity. Despite this, there are surprisingly few studies on the topic, and a knowledge gap remains in the literature. As one attempts to address this knowledge gap, a core outcome set (COS) is needed to guide the planning phases of future studies to allow synthesis and comparability of these studies. The objective of this study was to develop the COS-common peroneal neuropathy (CoPe) using a modified Delphi approach.
METHODS: A 5-stage approach was used to develop the COS-CoPe: 1) stage 1, consortium development; 2) stage 2, a literature review to identify potential outcome measures; 3) stage 3, a Delphi survey to develop consensus on outcomes for inclusion; 4) stage 4, a Delphi survey to develop definitions; and 5) stage 5, a consensus meeting to finalize COS and definitions. The study followed the COS-STAndards for Development (COS-STAD) recommendations.
RESULTS: The Core Outcomes in Nerve Surgery (COINS) Consortium comprised 23 participants, all neurological surgeons, representing 13 countries. The final COS-CoPe consisted of 31 data points/outcomes covering domains of demographics, diagnostics, patient-reported outcomes, motor/sensory outcomes, and complications. Appropriate instruments, methods of testing, and definitions were set. The consensus minimum duration of follow-up was 12 months. The consensus optimal time points for assessment were preoperatively and 3, 6, 12, and 24 months postoperatively.
CONCLUSIONS: The COINS Consortium developed a consensus COS and provided definitions, methods of implementation, and time points for assessment. The COS-CoPe should serve as a minimum set of data that should be collected in all future neurosurgical studies on common peroneal neuropathy. Incorporation of this COS should help improve consistency in reporting, data synthesis, and comparability, and should minimize outcome reporting bias.