目的:这项研究的目的是检查10周的高强度间歇训练(HIIT)和HIIT结合回路阻力训练(HCRT)对某些身体素质指标的影响,miR-9,-15a,-34a,-145和-155以及代谢风险因素,包括中年超重/肥胖女性的血脂状况和胰岛素抵抗。
方法:27名年龄在35-50岁之间的超重/肥胖妇女。随机分为HIIT(n=14)或HCRT(n=13)组。HIIT组进行了跑步练习(每次5次重复×4分钟),两次重复之间积极恢复,共10周,每周5次。HCRT组进行了10周的HIIT和阻力训练,每周3次HIIT训练和每周2次HCRT训练。人体测量(例如,体重),身体健康的选定组成部分(心血管健康,肌肉力量),miRNA的水平(miR-9,-15a,-34a,-145和-155),血脂谱(总胆固醇;TC,甘油三酯;TG,低密度脂蛋白胆固醇;LDL-C和高密度脂蛋白胆固醇;HDL-C),和胰岛素抵抗;HOMA-IR指数,在基线和第10周测量。
结果:ANOVA分析表明,所有人体测量指标在时间上没有明显的组交互作用(p>0.05),和最大耗氧量(VO2max)。一个重要的群体按时间互动,然而,发现一次重复的最大值(IRM;p<0.001,ES=0.751,中度)。事后检验表明,HCRT的前后平均1RM增加(p=0.001,ES=1.83,大)。miR-155在时间上存在显著组相互作用(p=0.05,ES=0.014,微不足道)。miR-155的水平经历了HIIT前后的增加(p=0.045,ES=1.232,大)。此外,TC的时间交互作用也有显著的分组(p=0.035,ES=0.187,微不足道),TG(p<0.001,ES=0.586,小),LDL-C(p=0.029,ES=0.200,小)和HDL-C(p=0.009,ES=0.273,小)。事后测试表明,TC(p=0.001,ES=1.44,大)和HDL-C(p=0.001,ES=1.407,大)的HCRT降低。HIIT导致TG的前后下降(p=0.001,ES=0.599,小),和LDL-C(p=0.001,ES=0.926,中度)。
结论:两种训练方法均未改善心血管适应性。但是,HRT改善下/上肢肌肉力量,和HIIT导致外周血单核细胞中miR-155表达增加。此外,HIIT和HCRT均改善了超重/肥胖中年妇女的某些代谢危险因素,包括脂质分布以及葡萄糖和胰岛素代谢。
背景:OSF,十月,第2023年。注册DOI:https://doi.org/10.17605/OSF。IO/UZ92E。osf.io/tc5ky.\"追溯注册\"。
OBJECTIVE: The purpose of this study was to examine the effects of 10 weeks of high-intensity interval training (HIIT) and HIIT combined with circuit resistance training (HCRT) on selected measures of physical fitness, the expression of miR-9, -15a, -34a, -145, and - 155 as well as metabolic risk factors including lipid profiles and insulin resistance in middle-aged overweight/obese women.
METHODS: Twenty-seven overweight/obese women aged 35-50 yrs. were randomized to HIIT (n = 14) or HCRT (n = 13) groups. The HIIT group performed running exercises (5 reps x 4 min per session) with active recovery between repetitions for 10 weeks with 5 weekly sessions. The HCRT group performed 10 weeks of HIIT and resistance training with 3 weekly HIIT sessions and 2 weekly HCRT sessions. Anthropometric measures (e.g., body mass), selected components of physical fitness (cardiovascular fitness, muscle strength), levels of miRNAs (miR-9, -15a, -34a, -145, and - 155), lipid profiles (total cholesterol; TC, Triglycerides; TG, low-density lipoprotein cholesterol; LDL-C and high-density lipoprotein cholesterol; HDL-C), and insulin resistance; HOMA-IR index, were measured at baseline and week 10.
RESULTS: An ANOVA analysis indicated no significant group by time interactions (p > 0.05) for all anthropometric measures, and maximum oxygen consumption (VO2max). A significant group by time interaction, however, was found for the one-repetition maximum (IRM; p < 0.001, ES= 0.751 , moderate). A post-hoc test indicated an increase in the pre-to-post mean 1RM for HCRT (p = 0.001, ES = 1.83, large). There was a significant group by time interaction for miR-155 (p = 0.05, ES = 0.014, trivial). Levels for miR-155 underwent pre-to-post HIIT increases (p = 0.045, ES = 1.232, large). Moreover, there were also significant group by time interactions for TC (p = 0.035, ES = 0.187, trivial), TG (p < 0.001, ES = 0.586, small), LDL-C (p = 0.029, ES = 0.200, small) and HDL-C (p = 0.009, ES = 0.273, small). Post-hoc tests indicated pre-post HCRT decreases for TC (p = 0.001, ES = 1.44, large) and HDL-C (p = 0.001, ES = 1.407, large). HIIT caused pre-to-post decreases in TG (p = 0.001, ES = 0.599, small), and LDL-C (p = 0.001, ES = 0.926, moderate).
CONCLUSIONS: Both training regimes did not improve cardiovascular fitness. But, HCRT improved lower/upper limb muscle strength, and HIIT resulted in an increase in miR-155 expression in peripheral blood mononuclear cells. Furthermore, HIIT and HCRT each improved selected metabolic risk factors including lipid profiles and glucose and insulin metabolism in overweight/obese middle-aged women.
BACKGROUND: OSF, October, 4th 2023. Registration DOI: https://doi.org/10.17605/OSF.IO/UZ92E . osf.io/tc5ky . \"Retrospectively registered\".