PDF(Pubmed)
Abstract：
UNASSIGNED: Left atrial dysfunction has shown to play a prognostic role in patients with ischemic cardiomyopathy (ICM) and is becoming a therapeutic target for pharmacological and non-pharmacological interventions. The effects of exercise training on the atrial function in patients with ICM have been poorly investigated. In the present study, we assessed the effects of a 12-week combined training (CT) program on the left atrial function in patients with ICM.
UNASSIGNED: We enlisted a total of 45 clinically stable patients and randomly assigned them to one of the following three groups: 15 to a supervised CT with low-frequency sessions (twice per week) (CTLF); 15 to a supervised CT with high-frequency sessions (thrice per week) (CTHF); and 15 to a control group following contemporary preventive exercise guidelines at home. At baseline and 12 weeks, all patients underwent a symptom-limited exercise test and echocardiography. The training included aerobic continuous exercise and resistance exercise. The analysis of variance (ANOVA) was used to compare within- and inter-group changes.
UNASSIGNED: At 12 weeks, the CTLF and CTHF groups showed a similar increase in the duration of the ergometric test compared with the control (ANOVA p < 0.001). The peak atrial longitudinal strain significantly increased in the CTHF group, while it was unchanged in the CTLF and control groups (ANOVA p = 0.003). The peak atrial contraction strain presented a significant improvement in the CTHF group compared with the CTLF and control groups. The left ventricular global longitudinal strain significantly increased in both the CTHF and the CTLF groups compared with the control group (ANOVA p = 0.017). The systolic blood pressure decreased in the CTHF and CTLF groups, while it was unchanged in the control group. There were no side effects causing the discontinuation of the training.
UNASSIGNED: We demonstrated that a CT program effectively improved atrial function in patients with ICM in a dose-effect manner. This result can help with programming exercise training in this population.
UNASSIGNED: We enlisted a total of 45 clinically stable patients and randomly assigned them to one of the following three groups: 15 to a supervised CT with low-frequency sessions (twice per week) (CTLF); 15 to a supervised CT with high-frequency sessions (thrice per week) (CTHF); and 15 to a control group following contemporary preventive exercise guidelines at home. At baseline and 12 weeks, all patients underwent a symptom-limited exercise test and echocardiography. The training included aerobic continuous exercise and resistance exercise. The analysis of variance (ANOVA) was used to compare within- and inter-group changes.
UNASSIGNED: At 12 weeks, the CTLF and CTHF groups showed a similar increase in the duration of the ergometric test compared with the control (ANOVA p < 0.001). The peak atrial longitudinal strain significantly increased in the CTHF group, while it was unchanged in the CTLF and control groups (ANOVA p = 0.003). The peak atrial contraction strain presented a significant improvement in the CTHF group compared with the CTLF and control groups. The left ventricular global longitudinal strain significantly increased in both the CTHF and the CTLF groups compared with the control group (ANOVA p = 0.017). The systolic blood pressure decreased in the CTHF and CTLF groups, while it was unchanged in the control group. There were no side effects causing the discontinuation of the training.
UNASSIGNED: We demonstrated that a CT program effectively improved atrial function in patients with ICM in a dose-effect manner. This result can help with programming exercise training in this population.
摘要：
■左心房功能障碍已显示在缺血性心肌病（ICM）患者中发挥预后作用，并正在成为药物和非药物干预的治疗目标。运动训练对ICM患者心房功能的影响研究甚少。在本研究中,我们评估了12周联合训练(CT)计划对ICM患者左心房功能的影响.
■我们总共招募了45名临床稳定的患者，并将他们随机分配到以下三组之一：15人接受低频率的监督CT检查（每周两次）（CTLF）；15人接受高频率的监督CT检查（每周三次）（CTHF）；15人遵循当代家庭预防性运动指南。在基线和12周，所有患者均接受了症状受限运动试验和超声心动图检查.训练包括有氧连续运动和抗阻运动。方差分析（ANOVA）用于比较组内和组间的变化。
■在12周时，与对照组相比,CTLF和CTHF组的测功试验持续时间增加相似(ANOVAp<0.001).CTHF组心房纵向应变峰值明显增加,而在CTLF组和对照组中没有变化（ANOVAp=0.003）。与CTLF和对照组相比，CTHF组的峰值心房收缩应变显着改善。与对照组相比，CTHF和CTLF组的左心室整体纵向应变均显着增加（ANOVAp=0.017）。CTLF和CTLF组收缩压下降,而对照组没有变化。没有导致训练中断的副作用。
■我们证明了CT程序以剂量效应方式有效改善了ICM患者的心房功能。这个结果可以帮助在这个人群中编程运动训练。
■我们总共招募了45名临床稳定的患者，并将他们随机分配到以下三组之一：15人接受低频率的监督CT检查（每周两次）（CTLF）；15人接受高频率的监督CT检查（每周三次）（CTHF）；15人遵循当代家庭预防性运动指南。在基线和12周，所有患者均接受了症状受限运动试验和超声心动图检查.训练包括有氧连续运动和抗阻运动。方差分析（ANOVA）用于比较组内和组间的变化。
■在12周时，与对照组相比,CTLF和CTHF组的测功试验持续时间增加相似(ANOVAp<0.001).CTHF组心房纵向应变峰值明显增加,而在CTLF组和对照组中没有变化（ANOVAp=0.003）。与CTLF和对照组相比，CTHF组的峰值心房收缩应变显着改善。与对照组相比，CTHF和CTLF组的左心室整体纵向应变均显着增加（ANOVAp=0.017）。CTLF和CTLF组收缩压下降,而对照组没有变化。没有导致训练中断的副作用。
■我们证明了CT程序以剂量效应方式有效改善了ICM患者的心房功能。这个结果可以帮助在这个人群中编程运动训练。
