这个未来,横截面,我们进行了队列观察性研究,以评估社区居住体弱老年人的久坐行为与动脉硬化相关血管问题之间的关联.我们包括116名日本社区居住的老年人(92名女性和24名男性),他们在2017年至2019年期间在横市和汉达市的两个长期护理保险机构中获得了日托。组间比较采用非配对t检验和卡方检验。以心-踝血管指数为因变量进行Logistic回归分析,久坐行为作为解释变量,和其他评估因子作为协变量。长期久坐行为(基于所有参与者的中位数)与调整年龄后的高心踝血管指数相关,性别,身体质量指数,踝臂指数,和1周内步行MET分钟(比值比3.086,95%置信区间1.275-7.467,p=0.012)。在调整其他变量(护理需求证书,骨骼肌质量指数,身体脂肪百分比,握力,步行时间为4米,etc),长期久坐行为与高心踝血管指数值之间存在显著关联(比值比4.977,95%置信区间1.497-16.554,p=0.009).结果研究证实,虚弱的老年人的长期久坐行为与通过心踝血管指数评估的动脉僵硬度之间存在关联。针对老年人的干预措施集中在每日久坐时间,以防止动脉硬化进展继发的老年综合征的发作和恶化,需要进一步研究。
This prospective, cross-sectional, cohort observational study was conducted to evaluate the associations between sedentary behavior and arteriosclerosis-related vascular issues in community-dwelling frail older adults. We included 116 Japanese community-dwelling older adults (92 females and 24 males) who availed daycare at two long-term care insurance facilities in the cities of Yokkaichi and Handa between 2017 and 2019. An unpaired t-test and the chi-square test were used for intergroup comparisons. Logistic regression analysis was conducted with cardio-ankle vascular index as the dependent variable, sedentary behavior as the explanatory variable, and the other evaluated factors as covariates. Long-time sedentary behavior (based on the median value for all participants) was associated with high cardio-ankle vascular index after adjusting for age, sex, body mass index, ankle-brachial index, and walking MET-minutes in 1 week (odds ratio 3.086, 95% confidence interval 1.275-7.467, p=0.012). After adjusting for other variables (care needs certificate, skeletal muscle mass index, body fat percentage, grip strength, 4-m walking duration, etc), there was a significant association between long-time sedentary behavior and high cardio-ankle vascular index values (odds ratio 4.977, 95% confidence interval 1.497-16.554, p=0.009). The results study confirmed an association between long-time sedentary behavior in frail older adults and the degree of arterial stiffness assessed by the cardio-ankle vascular index. Interventions in older adults that focus on daily sedentary time to prevent the onset and exacerbation of geriatric syndromes secondary to the progression of arteriosclerosis warrant further investigation.