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Abstract：
Introduction: Systemic Lupus Erythematosus (SLE) is an autoimmune disease associated with an increased risk of cardiovascular diseases (CVDs), leading to elevated mortality rates among patients. We aimed to evaluate the levels of cardio-ankle vascular index (CAVI), global longitudinal strain (GLS), ventricular-arterial coupling (VAC), and high-sensitivity cardiac troponin I (hsTnI) in SLE patients and to explore their relationship with clinical parameters. Methods: This cross-sectional study enrolled 82 SLE patients without evident cardiac or kidney impairment and 41 age- and sex-matched healthy controls. We comparatively evaluated CAVI, GLS, VAC, and hsTnI between SLE patients and controls, and we assessed their association among SLE patients with disease activity based on the SELENA-SLEDAI Activity Index. Multivariate regression analysis was performed to identify independent predictors of CAVI and hsTnI within the SLE cohort. Results: In comparison to healthy controls, SLE patients presented with significantly higher CAVI, GLS, and hsTnI levels, while VAC was significantly reduced (p < 0.001). Furthermore, SLE patients with active disease (SELENA-SLEDAI ≥ 4) exhibited higher levels of CAVI and troponin than those with inactive disease (p < 0.001). SLEDAI was an independent predictor of CAVI, while VAC and SLEDAI were independent determinants of hsTnI in the SLE cohort. Conclusions: SLE patients displayed abnormal levels of CAVI, VAC, GLS, and troponin compared to healthy individuals. Our findings implicate the potential of those CV novel CVD risk factors to refine screening and therapeutic strategies for this specific population.
摘要：
简介：系统性红斑狼疮（SLE）是一种与心血管疾病（CVDs）风险增加相关的自身免疫性疾病，导致患者死亡率升高。我们的目的是评估心踝血管指数（CAVI）的水平，全局纵向应变(GLS)，心室-动脉耦合(VAC),SLE患者的高敏肌钙蛋白I(hsTnI)水平及其与临床参数的关系。方法：这项横断面研究纳入了82例无明显心脏或肾脏损害的SLE患者和41例年龄和性别匹配的健康对照。我们比较评估了CAVI，GLS,VAC,SLE患者和对照组之间的hsTnI，我们根据SELENA-SLEDAI活动指数评估了SLE患者与疾病活动之间的关联。进行多变量回归分析以确定SLE队列中CAVI和hsTnI的独立预测因子。结果：与健康对照组相比，SLE患者表现出明显较高的CAVI，GLS,和hsTnI水平，而VAC显著降低(p<0.001)。此外，患有活动性疾病（SELENA-SLEDAI≥4）的SLE患者的CAVI和肌钙蛋白水平高于非活动性疾病（p<0.001）。SLEDAI是CAVI的独立预测因子，而VAC和SLEDAI是SLE队列中hsTnI的独立决定因素。结论:SLE患者CAVI水平异常,VAC,GLS,和肌钙蛋白与健康个体相比。我们的发现暗示了这些新的心血管疾病危险因素对这一特定人群的筛选和治疗策略的改进潜力。
