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Abstract：
Aortic pulse wave velocity (PWV) has been accepted as the gold standard for arterial stiffness measurement. However, PWV depends on blood pressure (BP). To eliminate the BP dependency of PWV, the cardio-ankle vascular index (CAVI) was developed. This study aimed to define the relationship between CAVI and aortic atherosclerosis or structure on multidetector computed tomography (MDCT). Patients with (n = 49) or without (n = 49) coronary artery disease were studied. The lumen and vessel diameters and wall thickness were calculated from the cross-sectional area at the pulmonary bifurcation level by 64-slice MDCT. The CAVI was measured within 3 days before MDCT. Multivariate analysis showed that the vessel diameter of the ascending and descending aorta on MDCT depends on age, body surface area, and diastolic BP. The CAVI significantly correlated with the vessel diameter ( r = .453) and wall thickness ( r = .387) of the thoracic descending aorta ( P < .001, respectively). The CAVI was an independent predictor of the descending aortic wall thickness on multiple stepwise regression analysis. These data suggest that CAVI, a simple index, is useful for evaluating thoracic aortic atherosclerosis.
摘要：
主动脉脉搏波速度（PWV）已被接受为动脉僵硬度测量的金标准。然而,PWV取决于血压（BP）。为了消除PWV的BP依赖性，建立了心踝血管指数（CAVI）。这项研究旨在定义CAVI与主动脉粥样硬化或多探测器计算机断层扫描（MDCT）结构之间的关系。研究了患有（n=49）或不患有（n=49）冠状动脉疾病的患者。通过64层MDCT从肺分叉水平的横截面积计算管腔和血管直径以及壁厚。在MDCT前3天内测量CAVI。多因素分析显示，MDCT上升、降主动脉的血管直径取决于年龄，体表面积,和舒张压血压。CAVI与胸降主动脉的血管直径（r=.453）和壁厚（r=.387）显着相关（分别为P<.001）。在多重逐步回归分析中，CAVI是降主动脉壁厚度的独立预测因子。这些数据表明CAVI,一个简单的索引，可用于评估胸主动脉粥样硬化。
