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Abstract：
Arterial stiffness increases with age, as well as in various pathological states, including obesity, diabetes mellitus, smoking, and dyslipidemia, and it has important consequences for cardiovascular health. Arterial stiffness plays a central role in hemodynamic dysfunction characterized by excess pulsatility; specifically, it leads to heart failure, cerebrovascular disease, and renal failure. Among measures of arterial stiffness, carotid-femoral pulse wave velocity is considered as the reference standard; however, it has not been incorporated into routine clinical practice. Cardio-ankle vascular index (CAVI), which is a marker of arterial stiffness measured from the origin of the aorta to the ankle, was developed in 2004. CAVI is based on stiffness parameter β, which is theoretically independent of blood pressure at the time of measurement. CAVI applies stiffness parameter β to arterial segments between the heart and ankle. The measurement of CAVI is simple and well-standardized, and its reproducibility and accuracy are acceptable. Several studies have demonstrated that CAVI is high in patients with various atherosclerotic risk factors, and treatment of cardiovascular risk factors and lifestyle modifications improve CAVI. Several prospective studies have investigated the association between CAVI and future cardiovascular events in the general population and in patients with cardiovascular risk factors. A cut-off value of 9.0 is proposed for predicting patients at a high risk of cardiovascular events. From this review, it is clear that CAVI may be useful in the prevention of cardiovascular disease.
摘要：
动脉僵硬度随着年龄的增长而增加,以及在各种病理状态下，包括肥胖,糖尿病,吸烟,和血脂异常，它对心血管健康有重要的影响。动脉僵硬在以过度搏动为特征的血液动力学功能障碍中起着重要作用；特别是，会导致心力衰竭,脑血管疾病，和肾衰竭。在动脉僵硬度的测量中，颈动脉-股动脉脉搏波速度被认为是参考标准;然而,它尚未被纳入常规临床实践。心踝血管指数(CAVI),这是从主动脉起点到脚踝测量的动脉僵硬度的标志，开发于2004年。CAVI基于刚度参数β，理论上与测量时的血压无关。CAVI将硬度参数β应用于心脏和踝关节之间的动脉段。CAVI的测量简单且标准化，其再现性和准确性是可以接受的。多项研究表明，在有各种动脉粥样硬化危险因素的患者中，CAVI较高，心血管危险因素的治疗和生活方式的改变可改善CAVI。一些前瞻性研究调查了普通人群和有心血管危险因素的患者中CAVI与未来心血管事件之间的关系。建议将临界值9.0用于预测心血管事件高风险的患者。从这篇评论来看，很明显,CAVI可能有助于预防心血管疾病.
