■骨关节炎(OA)是一种以软骨退化为特征的退行性关节疾病,骨重塑,和痛苦。最近的证据表明,维生素D不足,甲状旁腺激素(PTH)水平的变化,血脂异常可能在OA的病理生理学中起作用,影响钙稳态和骨骼健康。我们调查了维生素D,PTH水平,血脂谱,OA患者的钙稳态。
■这项病例对照研究涉及200名参与者,分为OA组和对照组,2023年4月至5月在三级护理中心。血清25-羟维生素D水平,PTH,总胆固醇,HDL,LDL,甘油三酯,和钙被测量。进行统计分析以评估这些生物标志物与OA状态之间的相关性。
与对照组相比,OA患者的维生素D水平明显降低,PTH和总胆固醇水平更高。维生素D不足很普遍,维生素D水平下降之间存在显著相关性,PTH升高,和血脂异常。这些发现表明潜在的代谢相互作用会影响OA的进展和症状学。
■该研究强调了维生素D不足,PTH水平改变,和OA患者的脂质失调,强调评估这些参数在OA临床管理中的重要性。需要进一步的研究来探索纠正OA中维生素D不足和脂质异常的治疗意义。
UNASSIGNED: Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, bone remodeling, and pain. Recent evidence suggests that Vitamin D insufficiency, alterations in parathyroid hormone (PTH) levels, and dyslipidemia may play roles in the pathophysiology of OA, affecting calcium homeostasis and bone health. We investigated the association between Vitamin D, PTH levels, lipid profile, and calcium homeostasis in OA patients.
UNASSIGNED: This case-control study involved 200 participants, divided into OA and control groups, at a tertiary care center from April to May 2023. Serum levels of 25-hydroxyvitamin D, PTH, total cholesterol, HDL, LDL, triglycerides, and calcium were measured. Statistical analysis was conducted to assess correlations between these biomarkers and OA status.
UNASSIGNED: OA patients demonstrated significantly lower Vitamin D levels and higher PTH and total cholesterol levels compared to controls. Vitamin D insufficiency was prevalent, with a notable correlation between decreased Vitamin D levels, elevated PTH, and dyslipidemia. These findings suggest a potential metabolic interplay affecting OA progression and symptomatology.
UNASSIGNED: The study highlights a significant association between Vitamin D insufficiency, altered PTH levels, and lipid dysregulation in OA patients, underscoring the importance of assessing these parameters in the clinical management of OA. Further research is needed to explore the therapeutic implications of correcting Vitamin D insufficiency and lipid abnormalities in OA.