PDF(Pubmed)
Abstract：
Mitochondria-associated endoplasmic reticulum membranes (MAMs) act as physical membrane contact sites facilitating material exchange and signal transmission between mitochondria and endoplasmic reticulum (ER), thereby regulating processes such as Ca2+/lipid transport, mitochondrial dynamics, autophagy, ER stress, inflammation, and apoptosis, among other pathological mechanisms. Emerging evidence underscores the pivotal role of MAMs in cardiovascular diseases (CVDs), particularly in aging-related pathologies. Aging significantly influences the structure and function of the heart and the arterial system, possibly due to the accumulation of reactive oxygen species (ROS) resulting from reduced antioxidant capacity and the age-related decline in organelle function, including mitochondria. Therefore, this paper begins by describing the composition, structure, and function of MAMs, followed by an exploration of the degenerative changes in MAMs and the cardiovascular system during aging. Subsequently, it discusses the regulatory pathways and approaches targeting MAMs in aging-related CVDs, to provide novel treatment strategies for managing CVDs in aging populations.
摘要：
线粒体相关的内质网膜（MAMs）充当物理膜接触位点，促进线粒体和内质网（ER）之间的物质交换和信号传递。从而调节过程，如Ca2+/脂质运输，线粒体动力学，自噬,ER压力,炎症,和细胞凋亡，在其他病理机制中。新的证据强调了MAM在心血管疾病（CVDs）中的关键作用，特别是与衰老相关的病理。衰老显著影响心脏和动脉系统的结构和功能，可能是由于抗氧化能力降低和与年龄相关的细胞器功能下降导致的活性氧（ROS）的积累，包括线粒体.因此,本文首先描述了作文，结构,和MAM的功能，随后探索老化过程中MAMs和心血管系统的退行性变化。随后，它讨论了在与衰老相关的CVD中靶向MAMs的调节途径和方法，为老年人群心血管疾病的管理提供新的治疗策略。
