Abstract：
The mitochondrial calcium uniporter complex (MCUc), serving as the specific channel for calcium influx into the mitochondrial matrix, is integral to calcium homeostasis and cellular integrity. Given its importance, ongoing research spans various disease models to understand the properties of the MCUc in pathophysiological contexts, but reported a different conclusion. Therefore, this review delves into the profound connection between MCUc-mediated calcium transients and cellular signaling pathways, mitochondrial dynamics, metabolism, and cell death. Additionally, we shed light on the recent advancements concerning the structural intricacies and auxiliary components of the MCUc in both resting and activated states. Furthermore, emphasis is placed on novel extrinsic and intrinsic regulators of the MCUc and their therapeutic implications across a spectrum of diseases. Meanwhile, we employed molecular docking simulations and identified candidate traditional Chinese medicine components with potential binding sites to the MCUc, potentially offering insights for further research on MCUc modulation.
摘要：
线粒体钙单向转运复合物(MCUc)，作为钙流入线粒体基质的特定通道，是钙稳态和细胞完整性的组成部分。鉴于其重要性,正在进行的研究跨越各种疾病模型，以了解MCUc在病理生理学背景下的特性，但报告了一个不同的结论。因此,这篇综述探讨了MCUc介导的钙瞬变与细胞信号通路之间的深刻联系，线粒体动力学，新陈代谢，细胞死亡。此外,我们揭示了有关静止和激活状态下MCUc的结构复杂性和辅助组件的最新进展。此外，重点放在MCUc的新型外在和内在调节因子上，以及它们在一系列疾病中的治疗意义。同时,我们采用分子对接模拟和确定候选中药成分与MCUc的潜在结合位点，可能为进一步研究MCUc调制提供见解。
