UNASSIGNED:维持体内平衡是健康和疾病(包括危重病人)所有生理过程的组成部分,可能会影响临床结局。本研究旨在评估血清钙的患病率,磷酸盐,AKI中维生素D3,FGF-23和PTH水平异常。
UNASSIGNED:单中心,prospective,在三级护理医院进行的观察性研究。纳入符合KDIGO标准的AKI患者。从符合条件的患者中抽取配对的血液样本-在AKI诊断后24小时内抽取第一样本,在5天后或出院时抽取第二样本。以测量血清钙(白蛋白校正)的较早者为准,磷酸盐,PTH,25(OH)Vit-D,和FGF-23水平。分析的临床结果包括生存状态,利用RRT,住院。
未经证实:在50例AKI患者中,大约四分之三是男性。参与者的平均年龄为57.32±11.47岁。大约一半的患者患有低钙血症,五分之四的患者患有低血清磷酸盐。近82%的患者25(OH)Vit-D水平较低,52%的患者PTH水平较高。接受RRT的患者的血清钙和PTH水平在数值上较高,但没有显着。RRT患者的FGF-23水平(pg/mL)显着高于非RRT患者(81.70±17.30,72.43±20.27,p=0.049),非幸存者(87.96±18.82vs幸存者57.11±15.19,p=0.045),住院时间高于中位数(109.67±26.97,低于中位数70.27±20.43,p=0.046)。在分析的所有骨和矿物质参数中,高FGF23水平始终与AKI的不良临床结果相关。
UNASSIGNED:本研究发现,AKI中钙和磷酸盐疾病的患病率很高,磷酸盐稳态失调,FGF-23水平升高与AKI的发病率和死亡率有关。
未经批准:辛格NP,PanwarV,AggarwalNP,ChhabraSK,GuptaAK,急性肾损伤中钙稳态的调节:一项前瞻性观察性研究。印度JCritCareMed2022;26(3):302-306。
UNASSIGNED: Maintaining homeostasis is an integral part of all physiological processes both in health and disease including critically ill patients and may impact clinical outcomes. The present
study was designed to assess prevalence of serum calcium, phosphate, vitamin-D3, FGF-23, and PTH levels abnormalities in AKI.
UNASSIGNED: Single-center, prospective, observational
study in a tertiary care hospital. Patients meeting KDIGO criteria for AKI were included. Paired blood samples were drawn from eligible patients-first sample within 24 hours of AKI diagnosis and second after 5 days or at time of hospital discharge, whichever was earlier for measuring serum calcium (albumin corrected), phosphate, PTH, 25(OH)Vit-D, and FGF-23 levels. Clinical outcomes analyzed included survival status, utilization of RRT, and hospital stay.
UNASSIGNED: Of the 50 patients with AKI, about three-fourths were males. Mean age of the participants was 57.32 ± 11.47 years. Around half of patients had hypocalcemia and four-fifths had low serum phosphate. Nearly 82% had low 25(OH)Vit-D and 52% cases had high PTH level. Patients who underwent RRT had numerically higher but not significant serum calcium and PTH levels. FGF-23 levels (pg/mL) were significantly higher in patients on RRT (81.70 ± 17.30 vs non-RRT, 72.43 ± 20.27, p = 0.049), nonsurvivors (87.96 ± 18.82 vs survivors 57.11 ± 15.19, p = 0.045), and those hospitalized for time of stay above median (109.67 ± 26.97 vs below median 70.27 ± 20.43, p = 0.046). Among all the bone and mineral parameters analyzed high FGF23 levels were consistently linked with poor clinical outcomes in AKI.
UNASSIGNED: The present
study found high prevalence of calcium and phosphate disorders in AKI with dysregulated phosphate homeostasis as evidenced from elevated FGF-23 levels linked with morbidity and mortality in AKI.
UNASSIGNED: Singh NP, Panwar V, Aggarwal NP, Chhabra SK, Gupta AK, Ganguli A. Regulation of Calcium Homeostasis in Acute Kidney Injury: A Prospective Observational
Study. Indian J Crit Care Med 2022;26(3):302-306.