在这项工作中,我们专注于基于PLA的静电纺纤维的生物活性和抗菌行为,纤维,用MgO和Mg(OH)2纳米颗粒增强,NPs。聚乳酸基纤维的演变是在形态方面,FTIR,XRD,和视觉外观。28天后,在羟基磷灰石生长方面讨论了生物活性,被认为是T28,浸入模拟体液中,SBF.特别是,在两个系统中,浸入SBF后的生物矿化过程在T14开始。沉淀晶体的数量通过增加两种NP的量而增加。沉淀晶体的化学组成也以浸入SBFT28后的Ca/P摩尔比表征,表明在两种增强纤维的表面上都存在羟基磷灰石。此外,观察到PLA基纤维的平均直径减小,达到纯PLA和PLA的平均直径最大减少46%和60%:OLA纤维,分别,在SBF中浸泡28天后。测试了PLA基电纺纤维中MgO和Mg(OH)2NPs对大肠杆菌的抗菌行为。大肠杆菌,作为革兰氏阴性细菌,和金黄色葡萄球菌,金黄色葡萄球菌,作为革兰氏阳性细菌,对于最高浓度的MgO和Mg(OH)2NPs,获得对革兰氏阴性菌大肠杆菌的最佳抗菌活性为21±2%和34±6%,分别。
In this work, we focused on the
bioactivity and antibacterial behavior of PLA-based electrospun fibers, efibers, reinforced with both MgO and Mg(OH)2 nanoparticles, NPs. The evolution of PLA-based efibers was followed in terms of morphology, FTIR, XRD, and visual appearance. The
bioactivity was discussed in terms of hydroxyapatite growth after 28 days, considered as T28, of immersion in simulated body fluid, SBF. In particular, the biomineralization process evidenced after immersion in SBF started at T14 in both systems. The number of precipitated crystals increased by increasing the amount of both NPs. The chemical composition of the precipitated crystals was also characterized in terms of the Ca/P molar ratio after T28 of immersion in SBF, indicating the presence of hydroxyapatite on the surface of both reinforced efibers. Moreover, a reduction in the average diameter of the PLA-based efibers was observed, reaching a maximum reduction of 46 and 60% in the average diameter of neat PLA and PLA:OLA efibers, respectively, after 28 days of immersion in SBF. The antibacterial behavior of the MgO and Mg(OH)2 NPs in the PLA-based electrospun fibers was tested against Escherichia coli, E. coli, as the Gram-negative bacteria, and Staphylococcus aureus, S. aureus, as the Gram-positive bacteria, obtaining the best antibacterial activity against the Gram-negative bacteria E. coli of 21 ± 2% and 34 ± 6% for the highest concentration of MgO and Mg(OH)2 NPs, respectively.