■Elizabethkingiaspp.感染最近有所增加,由于固有的抗菌素耐药性,它们很难治疗。本研究旨在探讨Elizabethkingiaspp肺部感染患者的临床特点。并揭示感染和死亡的危险因素。
■在这项回顾性病例对照研究中,根据细菌鉴定结果将患者分为感染组和对照组。感染组患者根据其住院结局进一步分为存活组和死亡组。比较不同组间的临床特点。我们进一步分析了分离菌株的抗菌药物敏感性测试结果。
■总共316名患者被分为感染(n=79),23人死亡,和对照组(n=237)。多因素logistic回归分析显示糖皮质激素用量(OR:2.35;95%CI:1.14~4.81;P=0.02),气管插管(OR:3.74;95%CI:1.62-8.64;P=0.002),粘菌素暴露(OR:2.50;95%CI:1.01-6.29;P=0.046)与Elizabethkingiaspp的肺部感染显着相关。高龄(OR:1.07,95%CI:1.00-1.15;P=0.046),高急性生理和慢性健康评估(APACHE)II评分(OR:1.21;95%CI:1.01-1.45;P=0.037),低白蛋白水平(OR:0.73,95%CI:0.56-0.96;P=0.025)与感染患者的住院死亡率显著相关.Elizabethkingiaspp.对头孢菌素有很强的抗药性,碳青霉烯类,大环内酯类,和氨基糖苷,对氟喹诺酮类药物敏感,米诺环素,和复方新诺明在体外。
■糖皮质激素消耗,气管插管,粘菌素暴露与Elizabethkingiaspp的肺部感染有关。对于危重病人。高龄患者,APACHEII评分很高,低白蛋白水平有较高的感染死亡风险.
UNASSIGNED: Elizabethkingia spp. infections have recently increased, and they are difficult to treat because of intrinsic antimicrobial resistance. This study aimed to investigate the clinical characteristics of patients with pulmonary infection with Elizabethkingia spp. and reveal the risk factors for infection and death.
UNASSIGNED: In this retrospective case-control study, patients were divided into infection and control groups based on the bacterial identification results. Patients in the infection group were further divided into survival and death groups according to their hospital outcomes. Clinical characteristics between different groups were compared. We further analyzed antimicrobial susceptibility testing results of the isolated strains.
UNASSIGNED: A total of the 316 patients were divided into infection (n = 79), 23 of whom died, and control (n = 237) groups. Multivariate logistic regression analysis showed that glucocorticoid consumption (OR: 2.35; 95% CI: 1.14-4.81; P = 0.02), endotracheal intubation (OR: 3.74; 95% CI: 1.62-8.64; P = 0.002), and colistin exposure (OR: 2.50; 95% CI: 1.01-6.29; P = 0.046) were significantly associated with pulmonary infection with Elizabethkingia spp. Advanced age (OR: 1.07, 95% CI: 1.00-1.15; P = 0.046), high acute physiology and chronic health evaluation (APACHE) II score (OR: 1.21; 95% CI: 1.01-1.45; P = 0.037), and low albumin level (OR: 0.73, 95% CI: 0.56-0.96; P = 0.025) were significantly associated with in-hospital mortality of infected patients. Elizabethkingia spp. was highly resistant to cephalosporins, carbapenems, macrolides, and aminoglycoside, and was sensitive to fluoroquinolones, minocycline, and co-trimoxazole in vitro.
UNASSIGNED: Glucocorticoid consumption, tracheal intubation, and colistin exposure were associated with pulmonary infection with Elizabethkingia spp. for critically ill patients. Patients with advanced age, high APACHE II score, and low albumin level had higher risk of death from infection.