这项研究的目的是评估接受胞浆内单精子注射周期的卵巢储备减少(DOR)患者的空卵泡综合征(EFS)的危险因素。在这项回顾性研究中,根据取卵当天有无空卵泡,将DOR患者分为2组.患者年龄,体重指数(BMI),抗苗勒管激素(AMH),基线卵泡刺激素(FSH)和雌二醇(E2)水平,基底窦卵泡计数(AFC),总促性腺激素剂量,并将刺激日记录为危险因素。使用逻辑回归方法和ROC曲线分析评估EFS与这些变量之间的关联。BMI增加,低AMH,较高的基线FSH,低基线AFC,更高的促性腺激素剂量,诱导排卵天数延长是DOR患者发生EFS的独立危险因素。ROC曲线分析显示,BMI,AMH,基线FSH,基线AFC,更高的促性腺激素剂量,更长的促排卵天数是该组的预测参数。根据目前的研究,BMI较高,降低AMH,较高的基线FSH,较低基线AFC,更高的促性腺激素剂量和更长的诱导排卵天数是卵巢储备功能降低患者发生EFS的独立危险因素.
The aim of this study is to evaluate the risk factors for empty follicle syndrome (EFS) in patients with diminished ovarian reserve (DOR) undergoing an intracytoplasmic sperm injection cycle. In this retrospective study, patients with DOR were divided into 2 groups according to the presence of empty follicles on the day of oocyte retrieval. Patient age, body mass index (BMI), anti-Müllerian hormone (AMH), baseline follicle stimulating hormone (FSH) and estradiol (E2) levels, basal antral follicle count (AFC), total gonadotropin dose, and day of stimulation were recorded as risk factors. The association between EFS and these variables was assessed using the logistic regression method and ROC curve analysis. Increased BMI, low AMH, higher baseline FSH, low baseline AFC, higher gonadotropin dose, and longer day of ovulation induction were independent risk factors for EFS in patients with DOR. ROC curve analysis showed that BMI, AMH, baseline FSH, baseline AFC, higher gonadotropin dose, and longer ovulation induction days were predictive parameters in this group. According to the current study, higher BMI, lower AMH, higher baseline FSH, lower baseline AFC, higher gonadotropin dose and longer ovulation induction days were independent risk factors for EFS in patients with reduced ovarian reserve.