{Reference Type}: Journal Article
{Title}: Association between anti-mullerian hormone and metabolic syndrome: insights from a prospective community-based study.
{Author}: Amiri M;Mousavi M;Noroozzadeh M;Farahmand M;Azizi F;Ramezani Tehrani F;
{Journal}: BMC Endocr Disord
{Volume}: 24
{Issue}: 1
{Year}: 2024 Jun 27
{Factor}: 3.263
{DOI}: 10.1186/s12902-024-01627-z
{Abstract}: <B>BACKGROUND: </B>Limited studies have investigated the relationship between Anti-Müllerian hormone (AMH) and metabolic syndrome (MetS), yielding inconclusive results. This study aimed to examine the relationship between AMH levels and MetS and its components in women from a general population.<BR><B>METHODS: </B>This prospective study recruited 769 women. Generalized Estimating Equation (GEE) models analyzed longitudinal trends of MetS components. Cox proportional hazard models evaluated effect of age-specific AMH tertiles on MetS occurrence, adjusting for confounders.<BR><B>RESULTS: </B>The GEE analysis indicated that women in the third tertile exhibited higher mean FPG compared to those in the first tertile of age-specific AMH (3 mg/dL; 95% CI: 0.40, 5.60; P = 0.024); however, this association became non-significant after adjustment. Notably, the second tertile showed a significant decrease in FPG mean changes over time (-0.69 mg/dL; 95% CI: -1.31, -0.07; P Interaction = 0.030). Women in the second and third tertiles of age-specific AMH demonstrated lower mean HDL-C compared to the first tertile (-2.96 mg/dL; 95% CI: -4.67, -1.26; P < 0.001 and -2.63 mg/dL; 95% CI: -4.31, -0.96; P = 0.002, respectively). The association between HDL-C changes and the second tertile remained significant after adjustment (-1.91 mg/dL; 95% CI: -3.68, -0.14; P = 0.034). No significant associations were observed between age-specific AMH tertiles and TG and SBP/DBP. Cox models revealed no significant differences in the hazard ratio of MetS between AMH tertiles after adjusting for confounders.<BR><B>CONCLUSIONS: </B>Despite minor variations in MetS components, AMH levels did not affect MetS risk in women from a general population.