PDF(Pubmed)
Abstract：
Background/Objectives: This paper undertakes an investigation into the implications of premature progesterone rise (PPR) on pregnancy outcomes in freeze-all strategy cycles. Methods: A retrospective cohort study encompassing 675 IVF/ICSI cycles using a freeze-all strategy was enrolled. The cycles were categorized into two groups based on serum progesterone levels at the time of hCG administration: 526 cycles had levels below 1.5 ng/mL, while 149 cycles had levels equal to or above 1.5 ng/mL. Results: The findings revealed a significantly higher number of mature follicles and retrieved oocytes in patients with PPR across all AMH categories. Multiple analyses revealed factors influencing PPR, including the duration of induction and the number of retrieved oocytes. Within the same oocyte retrieval number group, patients with PPR demonstrated non-inferior pregnancy outcomes compared to non-PPR patients. Upon adjustment for age, AMH, and total follicle-stimulating hormone (FSH) dosage, PPR maintained a positive correlation with the cumulative live birth rate (LBR). Conclusions: The study showed that PPR correlates with an increase in retrieved oocytes while maintaining similar embryo quality and oocyte retrieval rates and results in a higher cumulative LBR.
摘要：
背景/目标：本文对孕酮过早升高（PPR）对冷冻策略周期妊娠结局的影响进行了调查。方法：纳入一项回顾性队列研究，包括675个IVF/ICSI周期，采用全部冻结策略。根据hCG给药时的血清孕酮水平将周期分为两组：526个周期的水平低于1.5ng/mL，而149个周期的水平等于或高于1.5ng/mL。结果：研究结果表明，在所有AMH类别中，PPR患者的成熟卵泡和卵母细胞数量均显着增加。多项分析揭示了影响PPR的因素，包括诱导的持续时间和回收的卵母细胞的数量。在相同的卵母细胞提取号组中，与非PPR患者相比,PPR患者的妊娠结局表现为非劣.根据年龄调整后，AMH,和总卵泡刺激素（FSH）剂量，PPR与累积活产率（LBR）呈正相关。结论：研究表明，PPR与回收卵母细胞的增加相关，同时保持相似的胚胎质量和卵母细胞回收率，并导致更高的累积LBR。
