Abstract：
OBJECTIVE: To assess correlates of diagnosed and probable polycystic ovary syndrome (PCOS) among parous women.
METHODS: This study includes 557 women recruited from multi-specialty clinics in eastern Massachusetts. We categorized women as \"diagnosed PCOS\" based on medical records and self-reported clinician-diagnoses. Next, we constructed a category of \"probable PCOS\" for women without a diagnosis but with ≥2 of the following: ovulatory dysfunction (cycle length<21 or ≥35 days), hyperandrogenism (free testosterone>75th percentile), or elevated anti-Müllerian hormone (>75th percentile). We classified the remaining as \"no PCOS,\" and compared characteristics across groups.
RESULTS: 9.7% had diagnosed and 9.2% had probable PCOS. The frequency of irregular cycles was similar for diagnosed and probable PCOS. Free testosterone and AMH were higher for probable than diagnosed PCOS. Frequency of irregular cycles and both hormones were higher for the two PCOS groups vs. the no PCOS group. Obesity prevalence for diagnosed PCOS was twice that of probable PCOS (43.9% vs. 19.6%), yet the two groups had similar HbA1c and adiponectin.
CONCLUSIONS: Women with probable PCOS are leaner but have comparable glycemic traits to those with a formal diagnosis, highlighting the importance of assessing biochemical profiles among women with irregular cycles, even in the absence of overweight/obesity.
METHODS: This study includes 557 women recruited from multi-specialty clinics in eastern Massachusetts. We categorized women as \"diagnosed PCOS\" based on medical records and self-reported clinician-diagnoses. Next, we constructed a category of \"probable PCOS\" for women without a diagnosis but with ≥2 of the following: ovulatory dysfunction (cycle length<21 or ≥35 days), hyperandrogenism (free testosterone>75th percentile), or elevated anti-Müllerian hormone (>75th percentile). We classified the remaining as \"no PCOS,\" and compared characteristics across groups.
RESULTS: 9.7% had diagnosed and 9.2% had probable PCOS. The frequency of irregular cycles was similar for diagnosed and probable PCOS. Free testosterone and AMH were higher for probable than diagnosed PCOS. Frequency of irregular cycles and both hormones were higher for the two PCOS groups vs. the no PCOS group. Obesity prevalence for diagnosed PCOS was twice that of probable PCOS (43.9% vs. 19.6%), yet the two groups had similar HbA1c and adiponectin.
CONCLUSIONS: Women with probable PCOS are leaner but have comparable glycemic traits to those with a formal diagnosis, highlighting the importance of assessing biochemical profiles among women with irregular cycles, even in the absence of overweight/obesity.
摘要：
目的：评估产妇多囊卵巢综合征（PCOS）的诊断和可能的相关性。
方法：这项研究包括从马萨诸塞州东部多专业诊所招募的557名女性。我们根据医疗记录和自我报告的临床医生诊断将女性归类为“诊断为PCOS”。接下来,我们为未诊断但≥2项的女性构建了“可能的PCOS”类别：排卵功能障碍（周期长度<21天或≥35天），高雄激素血症（游离睾酮>第75百分位数），或升高的抗苗勒管激素（>第75百分位数）。我们把剩下的归类为“没有PCOS，“并比较了各组的特征。
结果：9.7%已诊断，9.2%可能患有PCOS。对于诊断的和可能的PCOS，不规则周期的频率相似。游离睾酮和AMH可能高于诊断的PCOS。两个PCOS组的不规则周期频率和两种激素均较高。无PCOS组。诊断为PCOS的肥胖患病率是可能的PCOS的两倍(43.9%vs.19.6%），然而两组的HbA1c和脂联素相似.
结论：可能患有PCOS的女性较瘦，但与正式诊断的女性具有可比的血糖特征，强调评估月经周期不规则的女性生化特征的重要性，即使没有超重/肥胖。
方法：这项研究包括从马萨诸塞州东部多专业诊所招募的557名女性。我们根据医疗记录和自我报告的临床医生诊断将女性归类为“诊断为PCOS”。接下来,我们为未诊断但≥2项的女性构建了“可能的PCOS”类别：排卵功能障碍（周期长度<21天或≥35天），高雄激素血症（游离睾酮>第75百分位数），或升高的抗苗勒管激素（>第75百分位数）。我们把剩下的归类为“没有PCOS，“并比较了各组的特征。
结果：9.7%已诊断，9.2%可能患有PCOS。对于诊断的和可能的PCOS，不规则周期的频率相似。游离睾酮和AMH可能高于诊断的PCOS。两个PCOS组的不规则周期频率和两种激素均较高。无PCOS组。诊断为PCOS的肥胖患病率是可能的PCOS的两倍(43.9%vs.19.6%），然而两组的HbA1c和脂联素相似.
结论：可能患有PCOS的女性较瘦，但与正式诊断的女性具有可比的血糖特征，强调评估月经周期不规则的女性生化特征的重要性，即使没有超重/肥胖。
