背景:这项研究的目的是评估生长,容忍度,与食用富含2'-岩藻糖基乳糖(2'-FL)人乳寡糖(HMO)的水解大米婴儿配方奶粉(HRF)相关的依从性结果,和预期婴儿群体中的核苷酸。
方法:这是一个非随机单组,多中心研究。研究配方为低变应原性HRF与2'-FL,二十二碳六烯酸(DHA),花生四烯酸(ARA),和核苷酸。婴儿0-90日龄谁是配方喂养和经历持续喂养不耐受症状,疑似食物蛋白(牛奶和/或大豆)过敏的症状,儿科医生从当地人群中招募了广泛水解婴儿配方奶粉或其他被认为是适当喂养选择的条件。主要结果是维持年龄体重z评分。重量,长度,头围,配方摄入量,公差措施,收集临床症状和问卷调查。有33名婴儿报名参加,27人完成了这项研究,关于研究产品。
结果:从第1次访问到第4次访问,婴儿的年龄体重z评分显示出统计学上的显着改善(p=0.0331)。有足够的每日体积摄入量762±28毫升/天,平均每日大便次数为2.1±0.3,平均大便一致性为2.38±0.18。改用HRF28天后,86.8±5.9%的症状在家长报告的第4次时得到缓解或好转。
结论:使用2'-FLHMO的HRF是安全的,良好的耐受性,并支持怀疑牛奶过敏或持续喂养不耐受的婴儿体重增加。
BACKGROUND: The purpose of this research was to assess the growth, tolerance, and compliance outcomes associated with the consumption of a hydrolyzed rice infant formula (HRF) enriched with 2\'-Fucosyllactose (2\'-FL) a Human Milk Oligosaccharide (HMO), and nucleotides in an intended population of infants.
METHODS: This was a non-randomized single-group, multicenter study. The study formula was a hypoallergenic HRF with 2\'-FL, Docosahexaenoic acid (DHA), Arachidonic acid (ARA), and nucleotides. Infants 0-90 days of age who were formula fed and experiencing persistent feeding intolerance symptoms, symptoms of suspected food protein (milk and/or soy) allergy, or other conditions where an extensively hydrolyzed infant formula was deemed an appropriate feeding option were recruited by pediatricians from their local populations. The primary outcome was maintenance of weight-for-age z-score. Weight, length, head circumference, formula intake, tolerance measures, clinical symptoms and questionnaires were collected. Thirty-three infants were enrolled, and 27 completed the study, on study product.
RESULTS: Weight-for-age z-scores of infants showed a statistically significant improvement from Visit 1 to Visit 4 (p = 0.0331). There was an adequate daily volume intake of 762 ± 28 mL/day, average daily number of stools of 2.1 ± 0.3, and mean rank stool consistency of 2.38 ± 0.18. After 28 days of switching to a HRF, 86.8 ± 5.9% of the symptoms resolved or got better by Visit 4 as reported by parents.
CONCLUSIONS: HRF with 2\'-FL HMO was safe, well tolerated, and supported weight gain in infants with suspected cow\'s milk allergy or persistent feeding intolerance.