背景:患有腹膜后血管肉瘤(HSA)的狗具有可变的术后中位生存时间(MST)。
目的:回顾性评估某些肿瘤相关因素的预后价值,如肿瘤大小,破裂,侵入邻近组织,淋巴结和远处转移受累,他们在患有腹膜后HSA的狗中进行了分析。
方法:回顾了10只仅接受手术切除的腹膜后HSA犬,并与脾(71)和肝(9)HSA进行了比较。使用Kaplan-Meier方法和对数秩分析比较因素之间的MSTs。多变量Cox比例风险分析用于比较出现部位之间的差异。
结果:与脾脏和肝脏HSA相比,腹膜后HSA显示出相对较长的术后MST,并且对于≥5cm(195天)的肿瘤,MST明显长于<5cm(70天)。脾脏HSA显示受累远处淋巴结(23天)和远处转移(39天)的MST明显短于阴性(83天,p=0.002和110天,p分别<0.001)。肝脏HSA还显示MST明显较短(与98天相比,16.5天,p=0.003)为远处转移。此外,总体HSA的风险比(HRs)及其森林地块显示为不良预后因素,出现部位(脾脏;HR2.78,p=0.016和肝脏;HR3.62,p=0.019),远处淋巴结受累(HR2.43,p=0.014),和远处转移(HR2.86,p<0.001),肿瘤大小≥5cm是更好的预后因素(HR0.53,p=0.037)。
结论:与总体HSA结合,与脾脏和肝脏HSA相比,腹膜后HSA显示出相对较长的术后MST,与肿瘤大小≥5cm相关,提示更好的预后因素。
BACKGROUND: Dogs with retroperitoneal hemangiosarcoma (HSA) exhibit variable postoperative median survival times (MST).
OBJECTIVE: To retrospectively evaluate the prognostic value of selected tumour-related factors, such as tumour size, rupture, invasion into adjacent tissue, involvement of lymph node and distant metastasis, they were analysed in dogs with retroperitoneal HSA.
METHODS: Ten dogs with retroperitoneal HSA managed solely with surgical excision were reviewed and compared with spleen (71) and liver (9) HSA. The Kaplan-Meier method and log-rank analysis were used compare MSTs between factors. Multivariable Cox proportional-hazard analysis was used to compare differences between arising sites.
RESULTS: Retroperitoneal HSA showed comparatively longer postoperative MST compared with that of spleen and liver HSA and demonstrated significantly longer MST (p = 0.003) for tumours ≥5 cm (195 days) than <5 cm (70 days). Spleen HSA revealed significantly shorter MSTs in involvement of distant lymph nodes (23 days) and distant metastasis (39 days) than those in negative (83 days, p = 0.002 and 110 days, p < 0.001, respectively). Liver HSA also revealed significantly shorter MST (16.5 days compared with 98 days, p = 0.003) for distant metastasis. Additionally, hazard ratios (HRs) and their forest plot for overall HSA revealed as poor prognostic factors, arising sites (spleen; HR 2.78, p = 0.016 and liver; HR 3.62, p = 0.019), involvement of distant lymph nodes (HR 2.43, p = 0.014), and distant metastasis (HR 2.86, p < 0.001), and as better prognostic factor of tumour size ≥5 cm (HR 0.53, p = 0.037).
CONCLUSIONS: In combination with overall HSA, retroperitoneal HSA shows comparatively longer postoperative MST compared to spleen and liver HSA, associated with tumour size ≥5 cm suggesting better prognostic factor.