PDF(Pubmed)
Abstract：
Dogs that had splenectomy are predisposed to fatal thrombotic conditions, and thrombocytosis is a risk factor for post-splenectomy hypercoagulability. However, in veterinary medicine, there are no specific therapeutic approaches for managing this hypercoagulability. This study aimed to determine the preventive effect of clopidogrel on post-operative hypercoagulability during the first 2 weeks post-splenectomy in dogs with splenic masses. This study included 12 dogs that had splenectomy. Seven dogs received no treatment (group A), and five were treated with clopidogrel (group B). Clopidogrel was loaded at 10 mg/kg on day 2 and continued at 2 mg/kg until day 14. Blood samples were collected on the day of surgery and 2, 7, and 14 days after splenectomy in both groups. In group B, thromboelastography (TEG) was performed on the same days. In group A, there was significant elevation of platelet counts on days 7 (p = 0.007) and 14 (p = 0.001) compared to day 0. In group B, the platelet counts were significantly elevated on day 7 (p = 0.032) but no significant difference was found on day 14 compared to day 0. Platelet counts on day 14 were significantly higher in group A than in group B (p = 0.03). The lower platelet counts were correlated with alterations in TEG parameters, and no significant differences were found in the K and α-angle values at all postoperative assessment points compared to day 0. Our study suggests that clopidogrel may reduce post-operative thrombocytosis and hypercoagulability in dogs that undergo splenectomy for splenic masses.
摘要：
做了脾切除术的狗容易患致命的血栓性疾病,血小板增多是脾切除术后高凝状态的危险因素。然而,在兽医学中，没有特定的治疗方法来控制这种高凝状态.本研究旨在确定氯吡格雷对脾肿块犬脾切除术后前2周术后高凝状态的预防作用。该研究包括12只进行脾切除术的狗。七只狗未接受治疗（A组），5例给予氯吡格雷治疗(B组)。在第2天以10mg/kg加载氯吡格雷,并继续以2mg/kg直到第14天。两组均在手术当天和脾切除术后2、7和14天收集血样。B组,在同一天进行血栓弹力图(TEG).在A组中,与第0天相比,第7天(p=0.007)和第14天(p=0.001)的血小板计数显著升高.B组,血小板计数在第7天显著升高(p=0.032),但在第14天与第0天相比无显著差异.在第14天，A组的血小板计数明显高于B组（p=0.03）。较低的血小板计数与TEG参数的改变相关，与第0天相比，所有术后评估点的K和α角值均未发现显着差异。我们的研究表明，氯吡格雷可以减少脾肿瘤切除犬的术后血小板增多和高凝状态。
