■全世界每年的鼻窦肿瘤发病率为每100,000人中0.5至1.0名患者。P63在上皮发育中起作用,并用作基底和肌上皮细胞的标记。p16的表达是由于人乳头瘤病毒(HPV)E7蛋白对视网膜母细胞瘤蛋白(pRb)的功能性失活而发生的。
■本研究旨在研究良恶性鼻窦肿块病变的组织学谱,并研究p63在不同类型鼻窦肿块病变中的免疫组织化学表达。它还旨在通过p16免疫组织化学确定原发性鼻窦肿块病变中高危HPV的发生率,并描绘HPV相关鼻窦病变的组织学谱。
■这项横断面研究是在2018年6月至2020年6月在一家三级保健医院对80例病例进行的。在研究形式中收集包括人口统计学参数在内的临床病史。记录标本的总体发现,并通过H&E染色进行组织病理学检查。对所有病例进行p63和p16表达的免疫组织化学染色。
■受影响的最常见年龄组为41-60岁,男女比例为1.67:1。非肿瘤性病变(38.7%)占大多数病例,其次是良性肿瘤性病变(31.3%)和恶性肿瘤性病变(30%)。在恶性肿瘤性病变中,p63阳性表达率为75%(p=0.005),p16阳性表达率为41.7%(p=0.023)。在良性和非肿瘤性病变中,p63阳性为21.4%(p=0.000),p16阳性为44.6%(p=0.040)。
■我们分析了p63和p16在不同谱系中的表达,例如癌,乳头状瘤,和鼻窦引起的神经外胚层分化,以及与其他临床病理参数的关系。这项研究表明p63的表达与鳞状细胞癌和鼻咽癌的相关性更高。鼻腔鼻窦恶性肿瘤也与HPV感染相关,可通过p16免疫染色识别,因此,可以为确定与HPV相关的任何明确的生物学和临床特征以及该患者人群的靶向治疗提供新的前景。
UNASSIGNED: The worldwide annual incidence of carcinomas of the sinonasal tract is 0.5 to 1.0 patients per 100,000 per year. P63 plays a role in epithelial development and is used as a marker for basal and myoepithelial cells. Expression of p16 occurs as a result of functional inactivation of the retinoblastoma protein (pRb) by the human papilloma virus (HPV) E7 protein.
UNASSIGNED: This study aims to study the histological spectrum of benign and malignant sinonasal mass lesions and to study the immunohistochemical expression of p63 in different type of sinonasal mass lesions. It also aims to ascertain the incidence of high-risk HPV in primary sinonasal mass lesions with p16 immunohistochemistry and delineate the histological spectrum of HPV-related sinonasal lesions.
UNASSIGNED: This cross-sectional study was conducted on 80 cases from June 2018 to June 2020 at a tertiary care hospital. Clinical history including demographic parameters were collected in the study proforma. The gross findings of the specimens noted and histopathological examination by H&E staining done. Immunohistochemistry staining for p63 and p16 expression was performed on all cases.
UNASSIGNED: Most common age group affected was 41-60 years with male:female ratio of 1.67:1. Nonneoplastic lesions (38.7%) comprised majority of the cases followed by benign neoplastic lesions (31.3%) and malignant neoplastic lesions (30%). Among the malignant neoplastic lesions, p63 showed positive expression in 75% (p = 0.005) and p16 showed positive expression in 41.7% (p = 0.023). Among benign and nonneoplastic lesions, p63 showed positivity in 21.4% (p = 0.000) and p16 showed positivity in 44.6% (p = 0.040).
UNASSIGNED: We analyzed p63 and p16 expression in varied lineages like carcinomas, papillomas, and neuroectodermal differentiation arising from the sinonasal tract and also in relation to other clinicopathological parameters. This study revealed p63 expression was associated more with the squamous cell carcinomas and nasopharyngeal carcinomas. Sinonasal tract malignancies are also associated with HPV infections that are identifiable by p16 immunostaining and, thus, could provide new prospects in identifying any definite biological and clinical characteristics associated with HPV as well as advancement in the targeted therapies for this patient population.