METHODS: Patients with head and neck mucosal melanoma who were surgically treated between 2007 and 2021 at the National Cancer Center Hospital were retrospectively analyzed.
RESULTS: A total of 47 patients were included in this study. The 5-year overall survival, disease-specific survival, locoregional control and relapse-free survival rates were 42%, 50%, 79% and 13%, respectively. The disease-specific survival of the oral mucosal melanoma group was significantly better than that of the sinonasal mucosal melanoma group (5-year disease-specific survival rate: 70% versus 37%, respectively; P = 0.04). Multivariate analyses revealed that sinonasal mucosal melanoma were independently significant adverse prognostic factor, for overall survival and disease-specific survival. Patients with oral mucosal melanoma patients had a higher incidence of lymph node metastasis than those with sinonasal mucosal melanoma patients (P < 0.0001).
CONCLUSIONS: This study demonstrated the survival outcomes of the largest cohort of patients with head and neck mucosal melanomas treated surgically at a single institution within the past 20 years in Japan. We found that survival outcomes and incidence of nodal metastases varied by site.
方法:对2007年至2021年在美国国家癌症中心医院接受手术治疗的头颈部粘膜黑色素瘤患者进行回顾性分析。
结果:本研究共纳入47例患者。5年总生存率,疾病特异性生存,局部控制和无复发生存率为42%,50%,79%和13%,分别。口腔粘膜黑色素瘤组的疾病特异性生存率明显优于鼻窦粘膜黑色素瘤组(5年疾病特异性生存率:70%对37%,分别为;P=0.04)。多因素分析显示,鼻腔鼻窦粘膜黑色素瘤是独立的显著不良预后因素,总生存率和疾病特异性生存率。口腔粘膜黑色素瘤患者的淋巴结转移发生率高于鼻窦粘膜黑色素瘤患者(P<0.0001)。
结论:本研究证明了日本过去20年中在单一机构手术治疗的最大头颈部粘膜黑素瘤患者队列的生存结果。我们发现,生存结果和淋巴结转移的发生率因部位而异。