Abstract：
OBJECTIVE: The role of elective neck dissection (END) in the management of clinical N0 (cN0) squamous cell carcinomas (SCC) of the sinonasal tract is unclear. In this systematic review, we evaluate the risk of occult nodal metastasis in sinonasal SCCs with cN0M0 tumors to support clinical decision making.
METHODS: A literature search was conducted in the following three electronic databases: Medline/PubMed, ScienceDirect, and Google Scholar. Articles were assessed for eligibility in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Two independent authors extracted the data. The Methodological Items for Non-Randomized Studies (MINORS) tool was used for the assessment of biases of each included study.
RESULTS: Our systematic review included six studies that met the inclusion criteria, all retrospective in design. The rate of histologically proven metastasis of sinonasal SCC to the clinically negative neck is 12.5%. Almost half of the positive cases are pathologically staged as N2 (6.5%).
CONCLUSIONS: Our systematic review provides the rate of sinonasal SCC occult metastasis to the neck so that the surgeons can discuss with patients the risks and possible merits of adding an elective neck management in the surgical plan.
METHODS: A literature search was conducted in the following three electronic databases: Medline/PubMed, ScienceDirect, and Google Scholar. Articles were assessed for eligibility in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Two independent authors extracted the data. The Methodological Items for Non-Randomized Studies (MINORS) tool was used for the assessment of biases of each included study.
RESULTS: Our systematic review included six studies that met the inclusion criteria, all retrospective in design. The rate of histologically proven metastasis of sinonasal SCC to the clinically negative neck is 12.5%. Almost half of the positive cases are pathologically staged as N2 (6.5%).
CONCLUSIONS: Our systematic review provides the rate of sinonasal SCC occult metastasis to the neck so that the surgeons can discuss with patients the risks and possible merits of adding an elective neck management in the surgical plan.
摘要：
目的：选择性颈清扫术（END）在临床N0（cN0）鼻窦鳞状细胞癌（SCC）治疗中的作用尚不清楚。在这次系统审查中，我们评估了有cN0M0肿瘤的鼻窦SCCs隐匿性淋巴结转移的风险,以支持临床决策.
方法：在以下三个电子数据库中进行了文献检索：Medline/PubMed，ScienceDirect,谷歌学者。根据系统审查和荟萃分析（PRISMA）声明的首选报告项目评估文章的资格。两位独立作者提取了数据。非随机研究的方法学项目（MINORS）工具用于评估每个纳入研究的偏见。
结果：我们的系统评价包括六项符合纳入标准的研究，所有的设计都是回顾性的。经组织学证实的鼻窦SCC转移至临床阴性颈部的发生率为12.5％。几乎一半的阳性病例在病理上为N2（6.5％）。
结论：我们的系统评价提供了鼻窦SCC隐匿性转移到颈部的发生率，以便外科医生可以与患者讨论在手术计划中增加选择性颈部管理的风险和可能的优点。
方法：在以下三个电子数据库中进行了文献检索：Medline/PubMed，ScienceDirect,谷歌学者。根据系统审查和荟萃分析（PRISMA）声明的首选报告项目评估文章的资格。两位独立作者提取了数据。非随机研究的方法学项目（MINORS）工具用于评估每个纳入研究的偏见。
结果：我们的系统评价包括六项符合纳入标准的研究，所有的设计都是回顾性的。经组织学证实的鼻窦SCC转移至临床阴性颈部的发生率为12.5％。几乎一半的阳性病例在病理上为N2（6.5％）。
结论：我们的系统评价提供了鼻窦SCC隐匿性转移到颈部的发生率，以便外科医生可以与患者讨论在手术计划中增加选择性颈部管理的风险和可能的优点。
