{Reference Type}: Journal Article
{Title}: Association Between 18F-Fluorodeoxyglucose Uptake and Mutation Status of Epidermal Growth Factor Receptor in Sinonasal Tract Cancer.
{Author}: Suzuki H;Sasaki E;Tamaki T;Kodaira T;Nishio M;Nishikawa D;Beppu S;Terada H;Sawabe M;Hanai N;
{Journal}: Anticancer Res
{Volume}: 43
{Issue}: 7
{Year}: 2023 Jul
{Factor}: 2.435
{DOI}: 10.21873/anticanres.16499
{Abstract}: <B>OBJECTIVE: </B>The Warburg effect of cancer has been applied to detect various carcinomas though the 18F-fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography with computed tomography (PET/CT). 18F-FDG-PET/CT in lung cancer predicted the mutation status of epidermoid growth factor receptor (EGFR). This study aimed to investigate whether 18F-FDG uptake parameters were significantly related to EGFR mutation status in patients with sinonasal tract squamous cell carcinoma (STSCC).<BR><B>METHODS: </B>Twenty-nine tumor specimens of primary STSCC from patients with definitive treatment were collected.<BR><B>RESULTS: </B>The 18F-FDG uptake from primary tumors was not different between mutant- and wild-status of EGFR on either Mann-Whitney U-test or the receiver operating curve. A metabolic tumor volume of ≥25 with the minimum p-value from the log-rank test for STSCC-specific survival was associated with a significantly shorter STSCC-specific, disease-free, local recurrence-free survival on the univariate and multivariate analyses adjusted for the clinical stage, treatment, and EGFR status.<BR><B>CONCLUSIONS: </B>18F-FDG-PET/CT did not predict mutation of the EGFR status in STSCC.