■许多观察性研究已经确定了银屑病(PsO)和银屑病关节炎(PsA)之间的关联,和自身免疫性疾病(AIDs);然而,这些关联的因果关系仍未确定.
■我们进行了双向双样本孟德尔随机化研究,以确定PsO和PsA与AIDs之间的因果关系和方向,如系统性红斑狼疮(SLE),克罗恩病(CD),溃疡性结肠炎(UC),多发性硬化症(MS),葡萄膜炎,大疱性类天疱疮(BP),桥本甲状腺炎(HT),类风湿性关节炎(RA),白癜风,强直性脊柱炎(AS)。因果推断是通过整合四个回归模型的结果得出的:方差反加权(IVW),MR-Egger,加权中位数,最大可能性。此外,我们进行了敏感性分析,以证实我们研究结果的可靠性.
■结果显示,CD[IVW赔率比(ORIVW),1.11;95%置信区间(CI),1.06-1.17;P=8.40E-06],白癜风(ORIVW,1.16;95%CI,1.05-1.28;P=2.45E-03)是PsO的危险因素,而BP可能会降低PsO的发生率(ORIVW,0.91;95%CI,0.87-0.96;P=1.26E-04)。CD(ORIVW,1.07;95%CI,1.02-1.12;P=0.01),HT(ORIVW,1.23;95%CI,1.08-1.40;P=1.43E-03),RA(ORIVW,1.11;95%CI,1.02-1.21,P=2.05E-02),作为(ORIVW,2.18;95%CI,1.46-3.27;P=1.55E-04),SLE(ORIVW,1.04;95%CI,1.01-1.08;P=1.07E-02)和白癜风(ORIVW,1.27;95%CI,1.14-1.42;P=2.67E-05)是PsA的危险因素。敏感性分析验证了结果的可靠性。
■我们的研究提供了某些AIDs与PsO和PsA之间潜在因果关系的证据。具体来说,CD和白癜风可能会增加患PsO的风险,而CD,HT,SLE,RA,AS,白癜风可能会增加患PsA的风险。此外,密切监测患有特定AIDs的PsO患者的病情至关重要,因为他们比没有艾滋病的人更有可能患上PsA。往前走,应更多关注PsA,并需要进一步探索其他PsO亚型。
UNASSIGNED: Numerous observational studies have identified associations between both psoriasis (PsO) and psoriatic arthritis (PsA), and autoimmune diseases (AIDs); however, the causality of these associations remains undetermined.
UNASSIGNED: We conducted a bidirectional two-sample Mendelian Randomization study to identify causal associations and directions between both PsO and PsA and AIDs, such as systemic lupus erythematosus (SLE), Crohn\'s disease (CD), ulcerative colitis (UC), multiple sclerosis (MS), uveitis, bullous pemphigoid (BP), Hashimoto\'s thyroiditis (HT), rheumatoid arthritis (RA), vitiligo, and ankylosing spondylitis (AS). The causal inferences were drawn by integrating results from four regression models: Inverse Variance Weighting (IVW), MR-Egger, Weighted Median, and Maximum Likelihood. Furthermore, we performed sensitivity analyses to confirm the reliability of our findings.
UNASSIGNED: The results showed that CD [IVW odds ratio (ORIVW), 1.11; 95% confidence interval (CI), 1.06-1.17; P = 8.40E-06], vitiligo (ORIVW, 1.16; 95% CI, 1.05-1.28; P = 2.45E-03) were risk factors for PsO, while BP may reduce the incidence of PsO (ORIVW, 0.91; 95% CI, 0.87-0.96; P = 1.26E-04). CD (ORIVW, 1.07; 95% CI, 1.02-1.12; P = 0.01), HT (ORIVW, 1.23; 95% CI, 1.08-1.40; P = 1.43E-03), RA (ORIVW, 1.11; 95% CI, 1.02-1.21, P = 2.05E-02), AS (ORIVW, 2.18; 95% CI, 1.46-3.27; P = 1.55E-04), SLE (ORIVW, 1.04; 95% CI, 1.01-1.08; P = 1.07E-02) and vitiligo (ORIVW, 1.27; 95% CI, 1.14-1.42; P = 2.67E-05) were risk factors for PsA. Sensitivity analyses had validated the reliability of the results.
UNASSIGNED: Our study provides evidence for potential causal relationships between certain AIDs and both PsO and PsA. Specifically, CD and vitiligo may increase the risk of developing PsO, while CD, HT, SLE, RA, AS, and vitiligo may elevate the risk for PsA. Additionally, it is crucial to closely monitor the condition of PsO patients with specific AIDs, as they have a higher likelihood of developing PsA than those without AIDs. Moving forward, greater attention should be paid to PsA and further exploration of other PsO subtypes is warranted.