未经授权:本研究旨在探讨毛脉络膜色素上皮病(PPE)的自然病程。
未经评估:一项回顾性队列研究。
UNASSIGNED:从截至2020年9月由548例CSC患者组成的京都中心性浆液性脉络膜视网膜病变(CSC)队列中,我们纳入了2013年1月至2016年12月期间连续单侧急性或慢性CSC患者。
未经授权:所有患者都接受了完整的眼科检查,包括多模态成像,如眼底自发荧光,谱域光学相干层析成像,和荧光素血管造影/吲哚菁绿血管造影和/或最佳相干断层扫描血管造影。对被诊断为CSC的眼睛进行了PPE筛查,并对其自然过程进行了评估。我们还评估了ARMS2rs10490924,CFHrs800292,TNFRSF10Ars13278062和GATA5rs6061548基因型与自然过程的关联。
未经批准:CSC的发生率,硬脉络膜新生血管病变,和毛脉络膜地理萎缩(GA)。
未经批准:总共,165例单侧CSC患者(平均年龄,55.7±12.6岁;女性,22.4%)来自京都CSC队列。其中,148例(89.7%)被诊断为非CSC眼患有PPE。生存分析显示,在6年的随访中,16.8%的PPE眼睛出现CSC,而非PPE眼睛没有。尽管遗传因素与CSC的发生没有显著的相关性(P>0.05,log-rank检验),脉络膜血管通透性过高(CVH)和中心凹下脉络膜厚度(SFCT)与CSC发生率显著相关(P=0.001,log-rank检验).生存分析表明,在6年的随访中,无CVH的眼睛和SFCT<300μm的眼睛没有发生CSC。在46.4个月的随访中,仅1只患有PPE的眼出现了毛脉络膜新生血管病。在任何研究的眼睛中都没有出现毛脉络膜GA。
UNASSIGNED:这项研究揭示了一个相对较大的日本人群中PPE的自然史。脉络膜血管通透性过高和SFCT是PPE眼CSC发生的重要危险因素。虽然目前的结果不能概括为所有的眼睛与PPE,这些发现具有重要的临床意义。
UNASSIGNED: To investigate the natural course of pachychoroid pigment epitheliopathy (PPE).
UNASSIGNED: A retrospective cohort study.
UNASSIGNED: From the Kyoto central serous chorioretinopathy (CSC) cohort consisting of 548 patients with CSC as of September 2020, we included consecutive unilateral patients with acute or chronic CSC between January 2013 and December 2016.
UNASSIGNED: All patients underwent complete ophthalmic examination, including multimodal imaging such as fundus autofluorescence, spectral-domain optical coherence tomography, and fluorescein angiography/indocyanine green angiography and/or optimal coherence tomography angiography. The fellow eyes of eyes diagnosed with CSC were screened for PPE, and their natural course was evaluated. We also evaluated the association of ARMS2 rs10490924, CFH rs800292, TNFRSF10A rs13278062, and GATA5 rs6061548 genotypes with the natural course.
UNASSIGNED: Incidence of CSC, pachychoroid neovasculopathy, and pachychoroid geographic atrophy (GA).
UNASSIGNED: In total, 165 patients with unilateral CSC (mean age, 55.7 ± 12.6 years; female, 22.4%) were included from the Kyoto CSC cohort. Among them, 148 (89.7%) were diagnosed as having PPE in their non-CSC eye. Survival analysis revealed that 16.8% of PPE eyes developed CSC during the 6-year follow up, whereas non-PPE eyes did not. Although genetic factors did not have significant association with CSC development (P > 0.05, log-rank test), choroidal vascular hyperpermeability (CVH) and subfoveal choroidal thickness (SFCT) were significantly associated with CSC incidence (P = 0.001, log-rank test). Survival analysis showed that eyes without CVH and eyes with SFCT < 300 μm did not develop CSC during the 6-year follow-up. Pachychoroid neovasculopathy developed in only 1 eye with PPE during a follow-up of 46.4 months. Pachychoroid GA did not develop in any of the studied eyes.
UNASSIGNED: This study revealed a natural history of PPE in a relatively large Japanese cohort. Choroidal vascular hyperpermeability and SFCT were significant risk factors for the development of CSC in PPE eyes. Although the current results cannot be generalized for all eyes with PPE, these findings present an important clinical implication.