PDF(Pubmed)
Abstract：
Genetic variations are critical for understanding clinical outcomes of infections including server acute respiratory syndrome coronavirus 2 (SARS CoV-2). The immunological reactions of human immune genes with SARS CoV-2 have been under investigation. Toll-like receptors (TLRs), a group of proteins, are important for microbial detections including bacteria and viruses. TLR4 can sense both bacterial lipopolysaccharides (LPS) and endogenous oxidized phospholipids triggered by Covid-19 infection. Two TLR4 single nucleotide polymorphisms (SNPs), Asp299Gly and Thr399Ile have been linked to infectious diseases. No studies have focused on these SNPs in association with Covid-19. This study aims to reveal the association between Covid-19 infection with these SNPs by comparing a group of patients and a general population. Restriction fragment length polymorphisms (RFLP) were used to identify the TLR4 SNPs in both the general population (n = 114) and Covid-19 patient groups (n = 125). The results found no association between the TLR4 polymorphisms and Covid-19 infections as the data showed no statistically significant difference between the compared groups. This suggested that these TLR4 SNPs may not be associated with Covid-19 infections.
摘要：
遗传变异对于了解包括服务器急性呼吸道综合症冠状病毒2（SARSCoV-2）在内的感染的临床结果至关重要。人类免疫基因与SARSCoV-2的免疫反应一直在研究中。Toll样受体(TLRs),一组蛋白质，对包括细菌和病毒在内的微生物检测很重要。TLR4可以感知由Covid-19感染触发的细菌脂多糖（LPS）和内源性氧化磷脂。两个TLR4单核苷酸多态性（SNPs），Asp299Gly和Thr399Ile与传染病有关。没有研究关注这些与新冠肺炎相关的SNP。这项研究旨在通过比较一组患者和普通人群，揭示新冠肺炎感染与这些SNP之间的关联。限制性片段长度多态性(RFLP)用于鉴定普通人群(n=114)和新冠肺炎患者组(n=125)中的TLR4SNP。结果发现TLR4多态性与新冠肺炎感染之间没有关联，因为数据显示对比组之间没有统计学上的显著差异。这表明这些TLR4SNP可能与新冠肺炎感染无关。
