PDF(Pubmed)
Abstract：
UNASSIGNED: Gut microbiome and inflammatory bowel disease (IBD) are implicated in the development of depression, but the effect of their interactions on the risk of depression remains unclear. We aim to analyze the effect of interactions between gut microbiome and IBD on the risk of depression, and explore candidate genes involving the interactions.
UNASSIGNED: Using the individual genotype and depression traits data from the UK Biobank, we calculated the polygenetic risk scores (PRS) of 114 gut microbiome, ulcerative colitis (UC), Crohn\'s disease (CD), and total IBD (CD + UC) respectively. The effects of interactions between gut microbiome and IBD on depression were assessed through a linear regression model. Moreover, for observed significant interactions between gut microbiome PRS and IBD PRS, PLINK software was used to test pair-wise single nucleotide polymorphisms (SNPs) interaction of corresponding gut microbiome PRS and IBD PRS on depression.
UNASSIGNED: We found 64 candidate interactions between gut microbiome and IBD on four phenotypes of depression, such as F_Lachnospiraceae (RNT) × (CD + UC) for patient health questionnaire-9 (PHQ-9) score (P = 1.48 × 10-3), F_Veillonellaceae (HB) × UC for self-reported depression (P = 2.83 × 10-3) and P_Firmicutes (RNT) × CD for age at first episode of depression (P = 8.50 × 10-3). We observed interactions of gut-microbiome-associated SNPs × IBD-associated SNPs, such as G_Alloprevotella (HB)-associated rs147650986 (GPM6A) × IBD-associated rs114471990 (QRICH1) (P = 2.26 × 10-4).
UNASSIGNED: Our results support the effects of interactions between gut microbiome and IBD on depression risk, and reported several novel candidate genes for depression.
UNASSIGNED: Using the individual genotype and depression traits data from the UK Biobank, we calculated the polygenetic risk scores (PRS) of 114 gut microbiome, ulcerative colitis (UC), Crohn\'s disease (CD), and total IBD (CD + UC) respectively. The effects of interactions between gut microbiome and IBD on depression were assessed through a linear regression model. Moreover, for observed significant interactions between gut microbiome PRS and IBD PRS, PLINK software was used to test pair-wise single nucleotide polymorphisms (SNPs) interaction of corresponding gut microbiome PRS and IBD PRS on depression.
UNASSIGNED: We found 64 candidate interactions between gut microbiome and IBD on four phenotypes of depression, such as F_Lachnospiraceae (RNT) × (CD + UC) for patient health questionnaire-9 (PHQ-9) score (P = 1.48 × 10-3), F_Veillonellaceae (HB) × UC for self-reported depression (P = 2.83 × 10-3) and P_Firmicutes (RNT) × CD for age at first episode of depression (P = 8.50 × 10-3). We observed interactions of gut-microbiome-associated SNPs × IBD-associated SNPs, such as G_Alloprevotella (HB)-associated rs147650986 (GPM6A) × IBD-associated rs114471990 (QRICH1) (P = 2.26 × 10-4).
UNASSIGNED: Our results support the effects of interactions between gut microbiome and IBD on depression risk, and reported several novel candidate genes for depression.
摘要：
未经证实：肠道微生物组和炎症性肠病（IBD）与抑郁症的发展有关，但它们的相互作用对抑郁风险的影响尚不清楚.我们旨在分析肠道微生物组和IBD之间的相互作用对抑郁症风险的影响。并探索涉及相互作用的候选基因。
未经评估：使用来自英国生物库的个体基因型和抑郁特征数据，我们计算了114个肠道微生物组的多遗传风险评分(PRS)，溃疡性结肠炎（UC），克罗恩病（CD），分别为总IBD(CD+UC)。通过线性回归模型评估肠道微生物组和IBD之间的相互作用对抑郁症的影响。此外，对于观察到的肠道微生物组PRS和IBDPRS之间的显著相互作用，PLINK软件用于测试相应肠道微生物组PRS和IBDPRS对抑郁症的配对单核苷酸多态性（SNP）相互作用。
UNASSIGNED：我们在四种抑郁症表型上发现了肠道微生物组和IBD之间的64个候选相互作用，如F_Lachnospirosaceae（RNT）×（CD+UC）患者健康问卷-9（PHQ-9）评分（P=1.48×10-3），F_Veillonellaceae（HB）×UC用于自我报告的抑郁症（P=2.83×10-3）和P_Firmicutes（RNT）×CD用于首次抑郁症发作时的年龄（P=8.50×10-3）。我们观察到肠道微生物组相关SNP×IBD相关SNP的相互作用，例如G_Alloprevotella（HB）相关的rs147650986（GPM6A）×IBD相关的rs114471990（QRICH1）（P=2.26×10-4）。
未经评估：我们的结果支持肠道微生物组和IBD之间的相互作用对抑郁风险的影响，并报道了几个新的抑郁症候选基因。
未经评估：使用来自英国生物库的个体基因型和抑郁特征数据，我们计算了114个肠道微生物组的多遗传风险评分(PRS)，溃疡性结肠炎（UC），克罗恩病（CD），分别为总IBD(CD+UC)。通过线性回归模型评估肠道微生物组和IBD之间的相互作用对抑郁症的影响。此外，对于观察到的肠道微生物组PRS和IBDPRS之间的显著相互作用，PLINK软件用于测试相应肠道微生物组PRS和IBDPRS对抑郁症的配对单核苷酸多态性（SNP）相互作用。
UNASSIGNED：我们在四种抑郁症表型上发现了肠道微生物组和IBD之间的64个候选相互作用，如F_Lachnospirosaceae（RNT）×（CD+UC）患者健康问卷-9（PHQ-9）评分（P=1.48×10-3），F_Veillonellaceae（HB）×UC用于自我报告的抑郁症（P=2.83×10-3）和P_Firmicutes（RNT）×CD用于首次抑郁症发作时的年龄（P=8.50×10-3）。我们观察到肠道微生物组相关SNP×IBD相关SNP的相互作用，例如G_Alloprevotella（HB）相关的rs147650986（GPM6A）×IBD相关的rs114471990（QRICH1）（P=2.26×10-4）。
未经评估：我们的结果支持肠道微生物组和IBD之间的相互作用对抑郁风险的影响，并报道了几个新的抑郁症候选基因。
