■MR引导的放射治疗增加了磁共振成像(MRI)的精度,使线性加速器的治疗益处。在每次治疗之前,MRI可以生成大量的成像数据以供分析。影像组学站在医学成像和肿瘤学研究的最前沿,致力于挖掘定量成像属性以伪造预测模型。然而,这些模型的鲁棒性经常受到挑战。
■为了评估特征提取的鲁棒性,我们使用0.35TMR直线加速器系统进行了可重复性研究,同时使用专门的体模和患者衍生的图像,关注胰腺癌病例。我们提取了基于形状的,来自患者衍生图像的一阶和纹理特征,以及来自幻影衍生图像的仅一阶和纹理特征。还通过等效性测试评估了模拟和第一部分图像之间的延迟的影响。
■从评估的107个功能中,58(54%)被认为是不可再现的:18在体模和患者图像中一致不一致,9个特定于基于幻影的分析,和31到患者派生的数据。
■我们的发现表明,从该双重数据集中提取的显着比例的放射学特征是不可靠的。至关重要的是丢弃这些不可重复的元素,以完善和增强放射学模型的开发,特别是对于胰腺癌的MR引导放疗。
UNASSIGNED: MR-guided radiotherapy adds the precision of magnetic resonance imaging (MRI) to the therapeutic benefits of a linear accelerator. Prior to each therapeutic session, an MRI generates a significant volume of imaging data ripe for analysis. Radiomics stands at the forefront of medical imaging and oncology research, dedicated to mining quantitative imaging attributes to forge predictive models. However, the
robustness of these models is often challenged.
UNASSIGNED: To assess the
robustness of feature extraction, we conducted reproducibility studies using a 0.35 T MR-linac system, employing both a specialized phantom and patient-derived images, focusing on cases of pancreatic cancer. We extracted shape-based, first-order and textural features from patient-derived images and only first-order and textural features from phantom-derived images. The impact of the delay between simulation and first fraction images was also assessed with an equivalence test.
UNASSIGNED: From 107 features evaluated, 58 (54 %) were considered as non-reproducible: 18 were uniformly inconsistent across both phantom and patient images, 9 were specific to phantom-based analysis, and 31 to patient-derived data.
UNASSIGNED: Our findings show that a significant proportion of radiomic features extracted from this dual dataset were unreliable. It is essential to discard these non-reproducible elements to refine and enhance radiomic model development, particularly for MR-guided radiotherapy in pancreatic cancer.