■锁定的视野计划可以使左乳腺癌的心脏和肺器官剂量。
■本研究的目的是比较左侧乳腺癌调强放疗中场锁定和场分裂计划之间的剂量学差异,为了探索场锁定对低剂量区的影响,并评估其对放射治疗目标的鲁棒性,为临床放疗方案的选择提供参考。
■共选择了30例左乳癌根治术后的患者,并制定了7场锁定场和分裂场计划,以比较目标区域和每个危险器官之间的剂量差异(ΔD),并在六个方向上引入3、5和7毫米的偏移量,并重新计算扰动的剂量分布,并根据计划的鲁棒性比较原始计划和扰动计划之间的ΔD。
■结果显示,D98%,两种计划的计划目标体积(PTV)的D95%和D平均值差异不大,没有统计学差异。锁定的野外计划为左肺提供了更好的保护,右肺,心,右乳和左冠状动脉前降支。对于PTVΔD98%,PTVΔD95%,PTVΔDmean,锁定字段计划的ΔD较高,对于LungLΔ5、LungLΔ20和心脏Δ平均值,与原计划相比,ΔD较高。
■得出的结论是,磁场锁定计划可以减少受影响肺的低剂量区域,并为其余的关键器官提供更好的保护,并且现场锁定计划在保护关键器官方面更加强大。同时,现场锁定计划对目标PTV的位置偏差显示出更高的敏感性。
UNASSIGNED: The locked vision plan can make the left breast cancer heart and lung organs dose.
UNASSIGNED: The aim of the present study was to compare the dosimetric differences between field-locked and field-split plans in intensity-modulated radiotherapy for left-sided breast cancer, to explore the effect of field-locking on the low-dose region, and to evaluate its
robustness to the radiotherapy target, in order to provide a reference for the selection of clinical radiotherapy protocols.
UNASSIGNED: A total of 30 patients were selected after radical left breast cancer surgery, and 7-field locked-field and split-field plans were developed to compare the dose difference (∆D) between the target area and each organ at risk, and to introduce offsets of 3, 5 and 7 mm in six directions and recalculate the perturbed dose distributions, and to compare the ∆D between the original and the perturbed plans according to the
robustness of the plans.
UNASSIGNED: The results revealed that the D98%, D95% and Dmean values of the planning target volume (PTV) of the two plans differed little and were not statistically different. The locked field plan provided better protection for the left lung, right lung, heart, right breast and left anterior descending coronary artery. For PTV∆D98%, PTV∆D95%, PTV∆Dmean, the ∆D was higher for the Locked Fields plan, and for LungL∆5, LungL∆20 and Heart∆mean, the ∆D was higher for the original plan.
UNASSIGNED: It was concluded that the field-locking plan could reduce the low-dose area of the affected lung and provide improved protection to the remaining critical organs, and the field-locking plan was more robust in protecting critical organs. Meanwhile, the field-locking plan showed higher sensitivity to positional deviation for target PTV.