未经评估:环境一氧化碳(CO)暴露与总呼吸系统疾病的死亡率和住院风险增加有关。然而,关于环境一氧化碳暴露导致特定呼吸系统疾病住院风险的证据有限.
未经授权:呼吸系统疾病每日住院数据,空气污染物,2016年1月至2020年12月,赣州市气象因子,中国。具有准泊松链接和滞后结构的广义加性模型用于估计环境CO浓度与总呼吸系统疾病住院率之间的关联。哮喘,慢性阻塞性肺疾病(COPD),上呼吸道感染(URTI),下呼吸道感染(LRTI),和流感肺炎。可能的混杂共污染物和按性别划分的效应改变,年龄,考虑了季节。
UNASSIGNED:共记录了72,430例呼吸道疾病住院病例。在环境CO暴露与呼吸系统疾病住院风险之间观察到显着的正暴露-反应关系。CO浓度每增加1mg/m3(lag0-2),总呼吸系统疾病住院治疗,哮喘,COPD,LRTI,流感肺炎增加了13.56(95%CI:6.76%,20.79%),17.74(95%CI:1.34%,36.8%),12.45(95%CI:2.91%,22.87%),41.25(95%CI:18.19%,68.81%),和13.5%(95%CI:3.41%,24.56%),分别。此外,在温暖的季节,环境一氧化碳与总呼吸道疾病和流感肺炎住院的相关性更强,而女性更容易受到与环境CO暴露相关的哮喘和LRTI住院的影响(均P<0.05)。
未经评估:简而言之,发现环境CO暴露与总呼吸系统疾病的住院风险之间存在显着的正暴露-反应关系,哮喘,COPD,LRTI,和流感肺炎。在与环境CO接触相关的呼吸道住院中,发现了季节和性别的影响变化。
Ambient carbon monoxide (CO) exposure is associated with increased mortality and hospitalization risk for total respiratory diseases. However, evidence on the risk of hospitalization for specific respiratory diseases from ambient CO exposure is limited.
Data on daily hospitalizations for respiratory diseases, air pollutants, and meteorological factors from January 2016 to December 2020 were collected in Ganzhou, China. A generalized additive model with the quasi-Poisson link and lag structures was used to estimate the associations between ambient CO concentration and hospitalizations of total respiratory diseases, asthma, chronic obstructive pulmonary disease (COPD), upper respiratory tract infection (URTI), lower respiratory tract infection (LRTI), and influenza-pneumonia. Possible confounding co-pollutants and effect modification by gender, age, and season were considered.
A total of 72,430 hospitalized cases of respiratory diseases were recorded. Significant positive exposure-response relationships were observed between ambient CO exposure and hospitalization risk from respiratory diseases. For each 1 mg/m3 increase in CO concentration (lag0-2), hospitalizations for total respiratory diseases, asthma, COPD, LRTI, and influenza-pneumonia increased by 13.56 (95% CI: 6.76%, 20.79%), 17.74 (95% CI: 1.34%, 36.8%), 12.45 (95% CI: 2.91%, 22.87%), 41.25 (95% CI: 18.19%, 68.81%), and 13.5% (95% CI: 3.41%, 24.56%), respectively. In addition, the associations of ambient CO with hospitalizations for total respiratory diseases and influenza-pneumonia were stronger during the warm season, while women were more susceptible to ambient CO exposure-associated hospitalizations for asthma and LRTI (all P < 0.05).
In brief, significant positive exposure-response relationships were found between ambient CO exposure and hospitalization risk for total respiratory diseases, asthma, COPD, LRTI, and influenza-pneumonia. Effect modification by season and gender was found in ambient CO exposure-associated respiratory hospitalizations.