Post-pandemic

大流行后
  • 文章类型: Journal Article
    COVID-19大流行导致行为发生了前所未有的变化。为了估计这些是否持续存在,CoMix社会接触调查的最后一轮是在四个国家进行的,当时所有社会限制都已经取消了几个月。我们对英国的全国代表性样本进行了调查,荷兰(NL),比利时(BE),瑞士(CH)。参与者被问及他们在前一天的接触和行为。我们计算了接触矩阵,并将接触水平与大流行前基线进行了比较,以估计R0。数据收集时间为2022年11月17日至12月7日。招募了7477名参与者。有些人被要求代表他们的孩子进行调查。只有14.4%的参与者报告在前一天戴着口罩。每个国家的成年人自我报告的疫苗接种率相似,约为86%。平均记录的接触者在NL中最高,每人每天9.9(95%置信区间[CI]9.0-10.8),在CH中最低,为6.0(95%CI5.4-6.6)。工作中的联系人在英国最低(每人每天1.4个联系人),在荷兰最高,每人每天2.8个联系人。英国的其他接触也较低,为每人每天1.6(95%CI1.4-1.9),NL最高,为每人每天3.4(95%CI43.0-4.0)。下一代方法表明,密切接触疾病的R0在英国大约是大流行前水平的一半,80%在NL和中间在其他两个国度。大流行似乎导致了接触模式的持久变化,预计将对许多不同病原体的流行病学产生影响。大流行后的进一步调查对于证实这一发现是必要的。
    The COVID-19 pandemic led to unprecedented changes in behaviour. To estimate if these persisted, a final round of the CoMix social contact survey was conducted in four countries at a time when all societal restrictions had been lifted for several months. We conducted a survey on a nationally representative sample in the UK, Netherlands (NL), Belgium (BE), and Switzerland (CH). Participants were asked about their contacts and behaviours on the previous day. We calculated contact matrices and compared the contact levels to a pre-pandemic baseline to estimate R0. Data collection occurred from 17 November to 7 December 2022. 7477 participants were recruited. Some were asked to undertake the survey on behalf of their children. Only 14.4 % of all participants reported wearing a facemask on the previous day. Self-reported vaccination rates in adults were similar for each country at around 86 %. Trimmed mean recorded contacts were highest in NL with 9.9 (95 % confidence interval [CI] 9.0-10.8) contacts per person per day and lowest in CH at 6.0 (95 % CI 5.4-6.6). Contacts at work were lowest in the UK (1.4 contacts per person per day) and highest in NL at 2.8 contacts per person per day. Other contacts were also lower in the UK at 1.6 per person per day (95 % CI 1.4-1.9) and highest in NL at 3.4 recorded per person per day (95 % CI 43.0-4.0). The next-generation approach suggests that R0 for a close-contact disease would be roughly half pre-pandemic levels in the UK, 80 % in NL and intermediate in the other two countries. The pandemic appears to have resulted in lasting changes in contact patterns expected to have an impact on the epidemiology of many different pathogens. Further post-pandemic surveys are necessary to confirm this finding.
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  • 文章类型: Journal Article
    COVID-19大流行可能对发作性睡病患者产生重大影响,然而,目前缺乏长期随访研究。这项研究旨在调查大流行期间和之后发作性睡病患者的症状严重程度和生活质量的变化。回顾性招募1型或2型发作性睡病(NT1,NT2)患者,并在2020年至2023年进行前瞻性随访。他们接受了包括Epworth嗜睡量表(ESS)在内的评估,超敏反应的视觉模拟量表(VAS),猝倒的VAS,简式36健康调查问卷(SF-36),一个睡眠日记。我们比较了封锁前的差异,封锁,封锁后,以及大流行后的时期,通过重复的方差分析或弗里德曼检验,使用Bonferroni测试进行事后分析。共有100名患者完成了为期4年的研究(平均年龄,24.06±7.00岁;55%男性)。我们观察到ESS的显着差异(p=0.037),总夜间睡眠(p=0.03),总睡眠时间(p=0.035),和睡眠效率(p=0.035)在研究期间。大流行后的身体角色功能也明显恶化(p=0.014)。特别是,NT1组的VAS-C评分显著降低(p<0.001),但在大流行后期间身体角色功能更差(p=0.009).发作性睡病患者在大流行后继续面临挑战。更灵活的生活方式和充足的睡眠时间可能是有益的,应强调服药依从性。
    The COVID-19 pandemic may have a significant impact on patients with narcolepsy, yet a long-term follow-up study is currently lacking. This study aims to investigate changes in symptom severity and the quality of life of patients with narcolepsy during and after the pandemic. Patients with type 1 or type 2 narcolepsy (NT1, NT2) were retrospectively recruited and prospectively followed from 2020 to 2023. They received evaluations including the Epworth Sleepiness Scale (ESS), the visual analog scale (VAS) for hypersomnolence, the VAS for cataplexy, the Short-form 36 Health Survey questionnaire (SF-36), and a sleep diary. We compared the differences between the pre-lockdown, the lockdown, the post-lockdown, and the post-pandemic periods by repeated measures ANOVA or the Friedman test, with the Bonferroni test for post hoc analysis. A total of 100 patients completed the 4-year study (mean age, 24.06 ± 7.00 years; 55% male). We observed significant differences in the ESS (p = 0.037), total nighttime sleep (p = 0.03), total sleep time (p = 0.035), and sleep efficiency (p = 0.035) during the study period. There was also significantly worse physical role functioning in the post-pandemic period (p = 0.014). In particular, the NT1 group had significantly decreased VAS-C scores (p < 0.001) but experienced worse physical role functioning in the post-pandemic period (p = 0.009). Patients with narcolepsy continue to face challenges after the pandemic. A more flexible lifestyle with an adequate sleep time may be beneficial, and medication adherence should be emphasized.
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  • 文章类型: Journal Article
    这项研究旨在确定大流行后时期泰国城市人口中环境风险暴露水平对COVID-19加强剂量疫苗接种预测因素的影响。六个研究地点,包括环境风险等级最高的三个省和环境风险等级最低的三个省,通过计算环境风险暴露指数进行选择。通过简单随机抽样技术选择每个省省会区的参与者,并使用结构化问卷进行访谈。在这项研究中,共有1315个人被纳入样本,使用多元回归分析确定加强剂量疫苗接种的最佳预测因子。结果显示,在超过PM10限值的总天数和肺癌死亡率较高的省份,环境风险暴露水平较高。在COVID-19大流行期间,给予COVID-19加强疫苗接种的数量占人口的43.4%。我们的多变量分析表明,工作年龄组的个人(≥25岁);受过高等教育的人(文凭及以上);全职工作(政府和私营部门);月收入高的人(≥USD144.1);以及环境暴露风险水平最低的地区的人在大流行后期间进行了加强免疫接种。总结一下,泰国COVID-19加强剂量疫苗接种接受率受到社会经济因素和环境问题的影响.这些发现改善了我们对全球大流行以及环境暴露如何影响行为变化模式的低估,并可以提高大流行后管理的有效性。
    This study aimed to identify the influence of environmental risk exposure levels on the predictive factors of COVID-19 booster dose vaccination in an urban Thai population in the post-pandemic era. Six study locations, including the three provinces with the highest environmental risk levels and the three provinces with the lowest environmental risk levels, were selected by calculating the environmental risk exposure indexes. Participants from the capital district of each province were chosen via the simple random sampling technique and interviewed using a structured questionnaire. A total of 1315 individuals were included in a sample in this study, and the best predictors of booster dose vaccination were determined using multiple regression analysis. The results showed that a high level of environmental risk exposure occurred in the provinces with a high number of total days exceeding the limits set for PM10 and high rates of mortality for lung cancer. The number of COVID-19 booster vaccinations given amount to 43.4% of the population during the post-COVID-19 pandemic period. Our multivariate analysis indicated that individuals in the working age group (≥25 years old); those with higher education (diploma degree and above); full-time employment (government and private sectors); those with high monthly incomes (≥USD144.1); and those in areas with the lowest risk level of environmental exposure significantly contributed to the number of booster dose vaccinations given during the post-pandemic period. To summarize, the rate of COVID-19 booster dose vaccination acceptance in Thailand was influenced by socio-economic factors with environmental concerns. These findings improve our understating of both the global pandemic and how environmental exposure affects behavioral change patterns and could improve the effectiveness of post-pandemic management.
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  • 文章类型: Journal Article
    背景:社区获得性肺炎(CAP)是全球死亡和住院的主要原因。细菌或社区获得性病毒(CARV)引起CAP。COVID-19相关的限制有效地减少了CARV的流通。
    目的:这项研究的目的是分析2020年中期至2023年中期成人CAP患者中CARV的比例。具体来说,我们的目的是比较流感病毒的发病率,18-59岁和≥60岁患者的SARS-CoV-2和RSV检测。
    方法:我们分析了21种社区获得性呼吸道病毒(CARV)和三种非典型细菌(百日咳博德特氏菌,嗜肺军团菌,和肺炎支原体)在鼻咽拭子样本中使用分子多重方法,多中心,德国研究小组CAPNETZ的跨国研究。我们在整个研究中使用了严格的纳入标准。
    结果:我们在364/1,388(26.2%)患者中确定了CARV。详细来说,我们在210/1,388(15.1%)中检测到SARS-CoV-2,鼻-/肠道病毒在64/1,388(4.6%),所有患者中有23/1,388(1.6%)的流感病毒和17/1,388(1.2%)的RSV。我们在≥60岁的患者中更频繁地检测到RSV和流感,特别是在22/23与上一个赛季相比。没有检测到非典型细菌。
    结论:从2023年开始,我们证明了CARV在CAP患者中的重新出现。目前可获得超过三分之二的检测到的病毒感染的有效疫苗或特异性抗病毒疗法。老年人群中疫苗可预防病毒的高检出率支持有针对性的疫苗接种运动。
    BACKGROUND: Community-acquired pneumonia (CAP) is a major global cause of death and hospitalization. Bacteria or community-acquired viruses (CARVs) cause CAP. COVID-19 associated restrictions effectively reduced the circulation of CARVs.
    OBJECTIVE: The aim of this study was to analyze the proportion of CARVs in adult patients with CAP from mid-2020 to mid-2023. Specifically, we aimed to compare the rate of influenza virus, SARS-CoV-2, and RSV detections in patients aged 18-59 years and ≥60 years.
    METHODS: We analyze the proportion of 21 community-acquired respiratory viruses (CARVs) and three atypical bacteria (Bordetella pertussis, Legionella pneumophila, and Mycoplasma pneumoniae) in nasopharyngeal swab samples using molecular multiplex methods within the prospective, multicentre, multinational study of the German study Group CAPNETZ. We used stringent inclusion criteria throughout the study.
    RESULTS: We identified CARVs in 364/1,388 (26.2 %) patients. In detail, we detected SARS-CoV-2 in 210/1,388 (15.1 %), rhino-/enterovirus in 64/1,388 (4.6 %), influenza virus in 23/1,388 (1.6 %) and RSV in 17/1,388 (1.2 %) of all patients. We detected RSV and influenza more frequently in patients ≥60 years, especially in 22/23 compared to the previous season. None of the atypical bacteria were detected.
    CONCLUSIONS: Beginning in 2023, we demonstrate a re-emergence of CARVs in CAP patients. Effective vaccines or specific antiviral therapies for more than two thirds of the detected viral infections are currently available. High detection rates of vaccine-preventable viruses in older age groups support targeted vaccination campaigns.
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  • 文章类型: Editorial
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  • 文章类型: Journal Article
    背景和目的:高海拔地区COVID-19患者的部分氧饱和度(PO2S)水平可能会降低。目的是评估高海拔地区COVID-19患者PO2S与重症监护病房(ICU)住院时间之间的关系。材料与方法:对69例COVID-19患者(36%为女性)入住ICU的临床资料进行分析。考虑组内类别(ICU中的“≤11天”和“>11天”)和PO2S身高类别(“<90%”和“≥90%”)的中值。使用针对混杂变量调整的逻辑回归和线性回归模型。结果:在ICU中>11天的患者PO2S≥90%的几率降低了84%(OR:0.16[CI:0.02,0.69],p=0.005)与ICU中≤11天的患者相比。PO2S增加1%,ICU停留时间减少0.22天(β:-0.22[CI:-0.33,-0.11],p<0.001),可能导致减少1.44天。结论:PO2S是评估高海拔地区COVID-19患者ICU住院时间的关键因素,是一种可获得且具有成本效益的措施。应将其用于感染患者,以补充大流行后ICU住院的预后。
    Background and Objectives: Patients at high altitudes with COVID-19 may experience a decrease in their partial oxygen saturation (PO2S) levels. The objective was to assess the association between PO2S and intensive care unit (ICU) stay in patients at high altitudes with COVID-19. Materials and Methods: Clinical records of 69 COVID-19 patients (36% women) admitted to the ICU were analyzed. Median values were considered for intra-group categories (\"≤11 days\" and \">11 days\" in the ICU) and for PO2S height categories (\"<90%\" and \"≥90%\"). Logistic regression and linear regression models adjusted for confounding variables were used. Results: Patients with >11 days in the ICU had 84% lower odds of having a PO2S ≥ 90% (OR: 0.16 [CI: 0.02, 0.69], p = 0.005) compared to those with ≤11 days in the ICU. An increase in PO2S by 1% reduced ICU stay by 0.22 days (β: -0.22 [CI: -0.33, -0.11], p < 0.001), potentially leading to a reduction of up to 1.44 days. Conclusions: PO2S is a crucial factor in estimating ICU stays for COVID-19 patients at high altitudes and serves as an accessible and cost-effective measure. It should be used in infected patients to complement the prognosis of post-pandemic ICU stay.
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  • 文章类型: Journal Article
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  • 文章类型: English Abstract
    本文介绍了“大流行后”(2022年-2023年上半年)俄罗斯人心理健康的实证社会医学和社会学研究。这项研究的目的是总结相应研究的结果。该评论涵盖了在RSCI中索引的国家科学期刊上的文章,以及由负责公众舆论分析的全俄罗斯研究组织以及联邦研究和教育组织进行的监测调查的结果。研究的选择标准包括2022年1月至2023年6月实施研究领域阶段;应用社会学调查技术;研究对象为俄罗斯联邦的全部人口或其受试者或单独的社会群体。它成立了,根据全俄罗斯和区域数据,在上述时期,俄罗斯居民的公共心理健康以波浪动力学为特征。2022年3月初和9月底焦虑水平的增加。抑郁症状患病率水平仍超过“大流行前”值。焦虑水平的增加在青年和妇女中更为典型。弱势群体也是与特种军事行动区接壤的领土的居民,战斗人员和乌克兰难民的家庭成员。在人口对心理精神病护理的法律需求条件下,实现了寻找俄罗斯公民心理安全替代工具的问题。
    The article presents review of empirical social medical and sociological studies of mental health of Russians in \"post-pandemic\" (2022 - first half of 2023). The purpose of the study is to generalize results of corresponding studies. The review covers the articles in national scientific journals indexed in the RSCI, the results of monitoring surveys carried out by both all-Russian research organizations handling analysis of public opinion and by Federal research and educational organizations. The criteria of selection of studies included the study field stage was implemented in January 2022 - June 2023; sociological survey technique was applied; the study object was whole population of the Russian Federation or its subject or a separate social group. it was established, on the basis of all-Russian and regional data, that in mentioned period public mental health of residents of Russia is characterized by wave dynamics. The increasing of anxiety level in beginning of March and in the end of September 2022. The level of depressive symptomatic prevalence still exceeded \"pre-pandemic\" values. The increased level of anxiety is more typical in the youth and women. The vulnerable groups are also residents of territories bordering on zone of special military operation, members of families of combatants and Ukraine refugees. In conditions of law demand of population for psychological psychiatric care the issue of searching alternative tools of psychological safety of Russian citizen is actualized.
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  • 文章类型: Journal Article
    COVID-19大流行对世界各地城市的旅行方式选择产生了重大影响。在对风险的认知和对感染的恐惧的驱使下,大流行导致对私人车辆和主动模式的偏好增加,对公共交通和乘车采购的偏好降低。随着旅行行为和模态偏好的发展,一个关键问题是,大流行是否会导致旅行方式选择的长期变化。本研究使用基于网络的调查数据来研究大流行后时代影响非通勤旅行方式选择的因素。具体来说,它使用陈述偏好数据来开发随机参数混合logit模型,用于比较不同收入和年龄组的关键变量的弹性。研究结果强调了社会人口统计学属性和大流行前的旅行习惯对预期的大流行后模式选择的影响。此外,结果表明,频繁使用私家车,公共交通,积极模式可能会在大流行后继续使用这些模式。此外,结果强调了对共享模式的感知可能会影响大流行后的模式选择决策.研究结果提供了有关政策措施的见解,这些措施可用于解决大流行期间私人车辆的使用增加和过境的使用减少,同时还强调需要确保人口的某些部分能够保持足够的流动性和获得运输的机会。
    The COVID-19 pandemic had a significant impact on travel mode choices in cities across the world. Driven by perceptions of risk and the fear of infection, the pandemic resulted in an increased preference for private vehicles and active modes and a reduced preference for public transit and ride-sourcing. As travel behavior and modal preferences evolve, a key question is whether the pandemic will result in long-term changes to travel mode choices. This study uses data from a web-based survey to examine the factors influencing mode choices for non-commuting trips in the post-pandemic era. Specifically, it uses stated preference data to develop a random parameter mixed logit model, which is used to compare the elasticity of key variables across different income and age groups. The results of the study highlight the influence of sociodemographic attributes and pre-pandemic travel habits on anticipated post-pandemic mode choices. Additionally, the results suggest that frequent users of private vehicles, public transit, and active modes are likely to continue to use these modes post-pandemic. Furthermore, the results highlight the potential for the perception of shared modes to influence post-pandemic mode choice decisions. The results of the study offer insights into policy measures that could be applied to address the increased use of private vehicles and reduced use of transit during the pandemic, while also emphasizing the need to ensure that certain segments of the population can maintain a sufficient level of mobility and access to transport.
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  • 文章类型: Multicenter Study
    背景:COVID-19大流行显著增加了一线护士职业倦怠的风险。然而,大流行后时期职业倦怠的患病率及其相关因素尚不清楚.本研究旨在调查大流行后一线护士的职业倦怠患病率,并确定中国的相关决定因素。
    方法:从2023年4月至7月,跨多个中心进行了横断面研究,重点关注积极参与COVID-19大流行的一线护士。数据收集是通过在线平台完成的。Maslach职业倦怠清单-人类服务调查用于评估职业倦怠的症状。使用多变量逻辑回归分析来确定与职业倦怠相关的因素。
    结果:在参加的2210名前线护士中,75.38%的人得分超过了倦怠的界限。多变量logistic回归分析显示,女性[比值比(OR)=0.41,95CI=0.29-0.58]和每周锻炼1-2次[OR=0.53,95CI=0.42-0.67]是预防职业倦怠的保护因素。相反,每月有10个或更多的夜班[OR=1.99,95CI=1.39-2.84],持有硕士或更高学位[OR=2.86,95%CI=1.59-5.15],健康状况不佳[OR=2.43,95%CI=1.93-3.08]和[OR=2.82,95CI=1.80-4.43],在病毒感染下[OR=7.12,95CI=2.10-24.17],与工作相关的压力升高[OR=1.53,95%CI=1.17-2.00]均与倦怠风险升高相关。
    结论:我们的研究结果表明,一线护士的大流行后倦怠受几个因素的影响,包括性别,每月夜班频率,学历,每周锻炼频率,健康状况,和病毒感染史。这些见解可以为旨在保护大流行后一线护士心理健康的干预措施提供信息。
    BACKGROUND: The COVID-19 pandemic has significantly increased the risk of burnout among frontline nurses. However, the prevalence of burnout and its associated factors in the post-pandemic era remain unclear. This research aims to investigate burnout prevalence among frontline nurses in the post-pandemic period and pinpoint associated determinants in China.
    METHODS: From April to July 2023, a cross-sectional study was carried out across multiple centers, focusing on frontline nurses who had been actively involved in the COVID-19 pandemic. The data collection was done via an online platform. The Maslach Burnout Inventory-Human Services Survey was utilized to evaluate symptoms of burnout. A multivariable logistic regression analysis was used to pinpoint factors associated with burnout.
    RESULTS: Of the 2210 frontline nurses who participated, 75.38% scored over the cut-off for burnout. Multivariable logistic regression revealed that factors like being female [odds ratio (OR) = 0.41, 95%CI = 0.29-0.58] and exercising 1-2 times weekly[OR = 0.53, 95%CI = 0.42-0.67] were protective factors against burnout. Conversely, having 10 or more night shifts per month[OR = 1.99, 95%CI = 1.39-2.84], holding a master\'s degree or higher[OR = 2.86, 95% CI = 1.59-5.15], poor health status[OR = 2.43, 95% CI = 1.93-3.08] and [OR = 2.82, 95%CI = 1.80-4.43], under virus infection[OR = 7.12, 95%CI = 2.10-24.17], and elevated work-related stress[OR = 1.53, 95% CI = 1.17-2.00] were all associated with an elevated risk of burnout.
    CONCLUSIONS: Our findings indicate that post-pandemic burnout among frontline nurses is influenced by several factors, including gender, monthly night shift frequency, academic qualifications, weekly exercise frequency, health condition, and viral infection history. These insights can inform interventions aimed at safeguarding the mental well-being of frontline nurses in the post-pandemic period.
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