Pilonidal sinus disease

  • 文章类型: Journal Article
    背景:人皮病(PD)是一种常见病,其全球发病率正在增加。手术是目前首选的治疗方法,但人们对新的微创技术越来越感兴趣。如鼻窦激光治疗(SiLaT)。
    目的:我们的主要目的是评估SiLaT治疗藏毛疾病的疗效。次要目标是评估发病率和患者满意度,并确定成功的预测因素。
    方法:所有成年患者,从2018年6月1日至2020年12月31日在我们部门接受SiLaT治疗原发性或复发性藏毛窦的患者被纳入研究.愈合被定义为关闭皮肤孔和没有渗漏或脓肿。
    结果:总计,111名连续患者,男女性别比例为2.1,平均年龄为28.8(±9.4)岁,包括在这项研究中。18例(16.2%)患者已经接受了PD手术。平均随访339.2(±221.4)天。观察到78.4%的治愈率,中位愈合时间为20.0天(15.0-30.0)。恢复正常活动的中位时间为3天(1-7)。术后唯一的并发症是出血,2例患者(1.8%)。82名患者(88.2%)报告对治疗“非常满意”。多变量分析显示,在研究变量中没有治愈的预测因素。
    结论:SiLaT是治疗PD的一种有效且安全的方法,患者满意度高。现在有必要将其定位在治疗算法内。
    BACKGROUND: Pilonidal disease (PD) is a common condition for which the global incidence is increasing. Surgery is the currently preferred approach to treatment but there is a growing interest in new minimally invasive techniques, such as sinus laser therapy (SiLaT).
    OBJECTIVE: Our primary objective was to assess the efficacy of SiLaT for the treatment of pilonidal disease. The secondary objectives were to evaluate morbidity and patient satisfaction and identify predictive factors of success.
    METHODS: All adult patients, who underwent SiLaT in our department for a primary or recurrent pilonidal sinus from June 1, 2018, to December 31, 2020, were included in the study. Healing was defined as the closure of cutaneous orifices and the absence of seepage or abscesses.
    RESULTS: In total, 111 consecutive patients, for whom the male/female sex ratio was 2.1 and the mean age 28.8 (± 9.4) years, were included in this study. Eighteen (16.2%) patients had already undergone prior surgery for PD. The mean follow-up was 339.2 (± 221.4) days. A healing rate of 78.4% was observed, with a median time to healing of 20.0 days (15.0-30.0). The median time to return to usual activities was three days (1-7). The only postoperative complication was bleeding, which occurred for two patients (1.8%). Eighty-two patients (88.2%) reported being \"very satisfied\" with the treatment. Multivariate analysis showed no predictive factors for healing among the studied variables.
    CONCLUSIONS: SiLaT is an efficient and safe procedure for the treatment of PD, with a high level of patient satisfaction. It will now be necessary to position it within the therapeutic algorithm.
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  • 文章类型: Systematic Review
    鼻窦病(PSD)表现为通常在肛门裂隙内出现的炎性皮肤状况。这种疾病的患病率在高收入国家有所不同。这种疾病与严重的身体和心理社会困扰有关。手术是管理PSD的一种选择;然而,手术方法各不相同,缺乏普遍接受的金本位制方法,导致目前的做法是多样化的,并受到持续的辩论。一个这样的争论点围绕手术后使用包装或选择非包装方法的决定。Mohamedahmed等人(2021)进行了系统评价,以评估在身体任何部位切开和引流皮肤脓肿后,脓肿腔填塞与非填塞的比较结果。本评论旨在批判性地评估Mohamedahmed等人(2021)的审查中使用的方法,并在PSD的治疗和管理背景下扩展研究结果。
    Pilonidal sinus disease (PSD) manifests as an inflammatory skin condition typically emerging within the anal cleft. The prevalence of this disease varies in high income countries. This disease is associated with significant physical and psychosocial distress. Surgery is an option for managing PSD; yet, surgical methods vary, and a universally accepted gold standard approach is lacking, leading to current practices that are diverse and subject to ongoing debate. One such point of contention revolves around the decision to use packing or opt for a non-packing approach following surgery. Mohamedahmed et al (2021) conducted a systematic review to evaluate the comparative outcomes of packing versus non-packing of an abscess cavity following incision and drainage of cutaneous abscess on any part of the body. This commentary aims to critically appraise the methods used within the review by Mohamedahmed et al (2021) and expand upon the findings in the context of treatment and management of PSD.
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  • 文章类型: Journal Article
    背景:在过去的几十年里,新的治疗方案已经出现了对于毛发窦疾病(PSD)的外科治疗.这项研究的目的是评估PSD患者在有或没有激光治疗的情况下进行环钻/凹陷切除手术的结果。
    方法:在大型三级医疗中心进行了一项回顾性队列研究,包括所有在2016年至2021年期间接受有/无激光治疗的环钻手术的PNS成年患者[作者插入月].倾向得分匹配用于解决混杂因素,主要结局是1年复发率.
    结果:该研究包括221例PSD患者,平均年龄23.73岁(男性占87.7%)。在无与伦比的队列中(仅130例环钻手术,91环钻手术+激光治疗),在平均年龄上观察到显著差异(23vs.25年;p<0.01)[使用中距离或ADDSD的权限]和外科医生的经验(p=0.014)。采用倾向得分匹配来克服混杂因素,导致一个匹配的队列,每组包括73名患者。增加激光治疗显示复发率显着降低(8.2%vs.32.9%;p<0.001)与无激光治疗的凹陷切除术相比。Logistic回归分析显示,激光的添加与较低的复发风险显着相关(OR0.23;95%CI0.089-0.633;p<0.01)。
    结论:在PNS患者中,激光治疗与环钻/凹陷切除手术的结合显著降低了复发率。需要进一步的前瞻性研究来证实我们的发现。
    Over the last decades, novel therapeutic options have emerged for the surgical treatment of pilonidal sinus disease (PSD). The aim of this study was to evaluate the outcomes of trephine/pit excision surgery with or without laser therapy in patients with PSD.
    A retrospective cohort study was conducted at a large tertiary medical center, including all adult patients with PNS who underwent trephine surgery with/without laser therapy between 2016 and 2021[AUTHORS TO INSERT MONTH]. Propensity score matching was used to address confounding factors, and the primary outcome was the 1-year recurrence rate.
    The study included 221 patients with PSD, with a mean age of 23.73 years (87.7% male). In the unmatched cohort (130 trephine surgery alone, 91 trephine surgery + laser therapy), significant differences were observed in mean age (23 vs. 25 years; p < 0.01)[AUTHROS TO USE MEDIAN PLUS RANGE OR ADD SD] and surgeons\' experience (p = 0.014). Propensity score matching was applied to overcome confounding factors, resulting in a matched cohort including 73 patients in each group. The addition of laser therapy demonstrated a significantly lower recurrence rate (8.2% vs. 32.9%; p < 0.001) compared to pit excision without laser therapy. Logistic regression analysis showed that the addition of laser was significantly associated with a lower risk for recurrence (OR 0.23; 95% CI 0.089-0.633; p < 0.01).
    The incorporation of laser therapy along with trephine/pit excision surgery significantly reduces the recurrence rate in patients with PNS. Further prospective studies are needed to confirm our findings.
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  • 文章类型: Journal Article
    背景鼻窦病(PSD)是一种由毛发滞留引起的慢性皮肤病,影响骶尾部裂隙。这项研究的目的是比较负压伤口疗法(NPWT)与常规日常敷料(DDs)在复杂或感染的藏毛窦道切除术后伤口愈合中的疗效。材料和方法该研究包括81名患有复杂或感染的毛发窦的广泛局部切除的个体。随机选择的参与者给予NPWT或常规敷料。在两组之间,住院时间,恢复日常活动所需的时间,并比较了完全闭合伤口所需的时间。结果42例患者接受NPWT,39例患者照常接受DDs。两组在手术时间或住院时间方面没有明显差异。然而,接受NPWT的患者最终伤口闭合速度更快(与常规DD相比,为59.24±10.21天,平均时间为75.31±14.68天,P=0.001),并较早恢复到正常活动(NPWT和常规DD的17.36天与21.75天,分别)。结论与接受标准DDs的患者相比,术后接受NPWT治疗的患者伤口愈合更快,恢复正常活动.只要可行,这一策略可用于改善患者康复.
    Background Pilonidal sinus disease (PSD) is a chronic skin condition caused by hair retention that affects the sacrococcygeal cleft. The purpose of this study is to compare the efficacy of negative pressure wound therapy (NPWT) to routine daily dressings (DDs) in wound healing after complex or infected pilonidal sinus tract excision. Materials and methods The study included 81 individuals who had extensive local excisions for pilonidal sinuses that were complex or infected. Randomly selected participants were given either NPWT or the usual dressing. Between the two groups, the length of hospitalization, the amount of time needed to resume daily activities, and the amount of time needed for full wound closure were compared. Results Forty-two patients received NPWT, while 39 patients received DDs as usual. There was no discernible difference between the two groups in terms of operating time or hospital stay. However, patients who underwent NPWT experienced a quicker final wound closure (59.24 ± 10.21 days compared to routine DD with a mean time of 75.31 ± 14.68 days, P = 0.001) and returned to normal activities earlier (17.36 versus 21.75 days in NPWT and routine DD, respectively). Conclusion Compared to patients who received standard DDs, those who were postoperatively managed with NPWT showed faster wound healing and return to normal activities. Whenever feasible, this strategy may be employed to improve patient recovery.
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  • 文章类型: Systematic Review
    在过去的几年中,针对毛发窦疾病(PSD)的非切除技术已越来越受欢迎。这项研究的目的是回顾非切除技术的短期和长期结果,特别关注窦腔内壁治疗的累加效应以及原发性和复发性PSD之间的差异。在Embase进行了系统的搜索,Medline,WebofScience核心合集,Cochrane和GoogleScholar数据库,用于研究PSD的非切除技术,包括带有或不带有额外激光或苯酚处理的凹坑拾取技术,拆除屋顶,内镜技术和凝血酶明胶基质的应用。结果是复发率,治愈率,并发症发生率,伤口愈合时间和恢复日常活动所需的时间。总的来说,包括8100名患者的31项研究。非切除技术的总体治愈率为67%至100%。取坑的复发率,根据后续时间,去屋顶和明胶基质的应用从0到16%不等。附加激光后的复发率,苯酚和内镜技术从0到29%不等。并发症发生率从0到16%不等,伤口愈合时间在3到47天之间。恢复日常活动的时间从一到九天不等。非切除技术与快速恢复和低发病率相关,但复发率高。尝试额外治疗鼻窦内衬的技术比单独进行凹陷摘除的复发率更差。原发性疾病和复发性疾病之间的复发率没有差异。
    Non-excisional techniques for pilonidal sinus disease (PSD) have gained popularity over the last years. The aim of this study was to review short and long-term outcomes for non-excisional techniques with special focus on the additive effect of treatment of the inner lining of the sinus cavity and the difference between primary and recurrent PSD. A systematic search was conducted in Embase, Medline, Web of Science Core Collection, Cochrane and Google Scholar databases for studies on non-excisional techniques for PSD including pit picking techniques with or without additional laser or phenol treatment, unroofing, endoscopic techniques and thrombin gelatin matrix application. Outcomes were recurrence rates, healing rates, complication rates, wound healing times and time taken to return to daily activities. In total, 31 studies comprising 8100 patients were included. Non-excisional techniques had overall healing rates ranging from 67 to 100%. Recurrence rates for pit picking, unroofing and gelatin matrix application varied from 0 to 16% depending on the follow-up time. Recurrence rates after additional laser, phenol and endoscopic techniques varied from 0 to 29%. Complication rates ranged from 0 to 16%, and the wound healing time was between three and forty-seven days. The return to daily activities varied from one to nine days. Non-excisional techniques are associated with fast recovery and low morbidity but recurrence rates are high. Techniques that attempt to additionally treat the inner lining of the sinus have worse recurrence rates than pit picking alone. Recurrence rates do not differ between primary and recurrent disease.
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  • 文章类型: Case Reports
    背景:手术引流管破裂是术后使用引流系统的一个不寻常的负面后果。虽然很罕见,文献中记录了多种管理方法。
    方法:一名19岁男性患者,有复发性藏毛窦疾病史,手术间隔4个月两次。他到我们医院接受术后随访,在此期间对插入的引流管进行了评估。在抽出排水管的同时,它的一部分被损坏和遗漏。通过腰骶区域计算机断层扫描(CT)扫描评估错位引流的位置。决定使用介入放射学技术进行侵入性较小的方法,以避免广泛切除和切口重新开放的并发症以及延长的愈合时间。进行透视检查以创建三维前外侧,正面后视图。然后通过微创技术成功回收了破碎的引流。术后时间顺利。
    结论:排水碎裂和/或移位是一项极具挑战性的事件,需要高度创新的干预措施。开放手术技术和内窥镜方法有多种治疗选择。
    结论:本案例强调了透视作为一种出色的有效选择的潜在作用,可以在局部麻醉下在床边迅速安全地进行,并减少患者的住院时间。
    BACKGROUND: Fragmentation of the surgical drain is an unusual negative consequence of using a drainage system postoperatively. Even though it is rare, multiple management approaches were documented in the literature.
    METHODS: A 19-year-old male patient who had a history of recurrent pilonidal sinus disease that was operated on twice 4 months apart. He presented to our hospital for postoperative follow-up, during which the inserted drain was assessed. While withdrawing the drain, part of it was damaged and missed. The location of the misplaced drain was assessed by a lumbosacral region computed tomography (CT) scan. The decision was made to proceed with less invasive methods using interventional radiology techniques to avoid wide excision and incision reopening complications and prolonged healing time. A fluoroscopy procedure was performed to create three-dimensional anterolateral, frontal posterior views. Then the fragmented drain was retrieved successfully by a minimally invasive technique. The postoperative period was uneventful.
    CONCLUSIONS: Drain fragmentation and/or dislodgement is a highly challenging event that requires highly innovative intervention. Multiple treatment options are available as open surgery techniques and endoscopic approaches.
    CONCLUSIONS: This case highlights the potential role of fluoroscopy as an outstanding effective choice that could be carried out promptly and safely at the bedside under local anesthetic and reduce the patient\'s hospital stay.
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  • 文章类型: Journal Article
    目标:如今,用新技术手术治疗藏毛窦疾病(PSD)是一个令人感兴趣的话题,因为传统方法与恢复日常生活的时间更长,并发症和复发率更高相关.最近,使用激光作为微创方法已成为PSD的手术治疗中的流行方法。在这项研究中,我们分析了激光治疗后的短期和中期结果,以及内窥镜摄像头的使用对结局的影响.
    方法:本研究纳入了2017年11月至2021年9月期间接受激光治疗的106例PSD患者。所有患者均接受1470nm二极管激光治疗。73例患者使用了内窥镜摄像机,并将其结果与未使用摄像机的患者进行了比较。随访期确定为至少1年。对数据进行回顾性分析。
    结果:有80例(75%)男性和26例女性患者。中位年龄为26岁(范围13-50岁)。术后第一天,26例(26.5%)患者没有任何疼痛,42例(42.8%)患者报告低度疼痛。恢复日常生活的平均时间为4.5±5.5(中位数2,范围1-30)天。并发症发生率为10.4%。86例(87.8%)患者完全恢复,平均完全恢复时间为27.4±15.9天。患者满意率为99.0%。复发率为11.0%。既往手术史和脓肿均与复发无关。使用内窥镜摄像头对术后疼痛没有影响,完全恢复,并发症,患者满意度,复发(p<0.05)。
    结论:激光治疗PSD是一种有前途的方法,具有术后疼痛少的优点,早日回归日常生活,患者满意度高,以及可接受的并发症和复发率。然而,需要进一步的研究来研究内窥镜相机在该手术中的作用,因为其可能的优势尚不清楚.
    Nowadays, surgical treatment of pilonidal sinus disease (PSD) with novel techniques is a topic of interest since conventional methods are associated with longer return to daily life and higher complication and recurrence rates. Recently, use of laser as a minimally invasive approach has become popular in the surgical treatment of PSD. In this study, we analyze the short- and mid-term results after laser treatment and the effect of endoscopic camera use on outcomes.
    A total of 106 patients with PSD who underwent laser treatment between November 2017 and September 2021 were included in this study. All patients were treated with a 1470-nm diode laser. Endoscopic camera was used in 73 patients and results of these were compared with those in whom camera was not used. Follow-up period was determined as a minimum of 1 year. Data were analyzed retrospectively.
    There were 80 (75%) male and 26 female patients. The median age was 26 (range 13-50) years. On the first postoperative day, 26 (26.5%) patients did not have any pain and 42(42.8%) patients reported low-grade pain. The mean time to return to daily life was 4.5 ± 5.5 (median 2, range 1-30) days. The complication rate was 10.4%. Eighty-six (87.8%) patients completely recovered and the mean complete recovery time was 27.4 ± 15.9 days. The patient satisfaction rate was 99.0%. The recurrence rate was 11.0%. Neither history of previous surgery nor abscess was associated with recurrence. Use of an endoscopic camera had no effect on postoperative pain, complete recovery, complications, patient satisfaction, and recurrence (p < 0.05).
    Laser treatment for PSD is a promising approach with the advantages of less postoperative pain, early return to daily life, high patient satisfaction, and acceptable complication and recurrence rates. Nevertheless, further studies are needed to investigate the role of endoscopic camera use in this procedure since its possible advantages could not be clarified.
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  • 文章类型: Randomized Controlled Trial
    目的:鼻窦病是一种特别影响年轻人群并导致劳动力流失的疾病。尽管已经定义了许多治疗方法,目前还没有“金标准”的治疗方法。我们的目的是评估双侧平行椭圆形皮瓣和Karydakis皮瓣在藏毛窦手术治疗中的术后效果。
    方法:本研究在安卡拉Numune培训研究医院结直肠外科进行。设计了一项前瞻性随机对照研究。因藏毛窦而接受手术的患者被纳入研究。将患者随机分为两组。一组采用双侧平行椭圆形皮瓣(BPEF)技术进行手术,另一组采用Karydakis皮瓣(KF)技术进行手术。术后疼痛,住院时间,伤口并发症,回到工作/学校所需的时间,并评估复发发生率。
    结果:共102名患者被纳入研究,BPEF组49和KF组53。BPEF组和KF组的住院时间相似(分别为1.41±0.81和1.45±0.84;p>0.05)。BPEF组术后疼痛减轻(2.47±1.02vs3.57±1.10,p<0.05)。BPEF组9例(18.2%)和KF组14例(26.2%)观察到伤口并发症。BPEF组返回工作/学校的时间较短(21.06±6.37vs27.04±7.45;p<0.05)。BPEF组中有2例(4%)患者复发,KF组中有3例(5.6%)患者复发(p>0.05)。
    结论:接受双侧平行椭圆皮瓣技术手术的患者术后疼痛较轻,重返工作/学校的时间较短。两组术后并发症和复发率相似。
    背景:clinicaltrials.gov标识符:NCT05851690。(5/11/2023)(追溯注册)。
    OBJECTIVE: Pilonidal sinus disease is a disease that especially affects the young population and causes loss of workforce. Although many treatment methods have been defined, there is still no \"gold standard\" treatment method. Our objective was to evaluate the postoperative results of bilateral parallel elliptical flap and Karydakis flap in the surgical treatment of pilonidal sinus.
    METHODS: This study was conducted at the Colorectal Surgery Department of Ankara Numune Training and Research Hospital. It designed a prospective randomized controlled study. Patients that underwent surgery due to pilonidal sinus were included in the study. The patients were randomly divided into two groups. Surgery was performed with the bilateral parallel elliptical flap (BPEF) technique in one group and the Karydakis flap (KF) technique in the other group. Postoperative pain, length of hospital stay, wound complications, time taken to return to work/school, and recurrence incidence were evaluated.
    RESULTS: A total of 102 patients were included in the study, 49 in the BPEF group and 53 in the KF group. The length of hospital stay was similar in the BPEF and KF groups (1.41 ± 0.81 and 1.45 ± 0.84, respectively; p > 0.05). There was less postoperative pain in the BPEF group (2.47 ± 1.02 vs 3.57 ± 1.10, p < 0.05). Wound complications were observed in nine patients in the BPEF group (18.2%) and 14 patients in the KF group (26.2%). The time to return to work/school was shorter in the BPEF group (21.06 ± 6.37 vs 27.04 ± 7.45; p < 0.05). Recurrence developed in two (4%) patients in the BPEF group and three (5.6%) patients in the KF group (p > 0.05).
    CONCLUSIONS: The patients who underwent surgery with the bilateral parallel elliptical flap technique had less pain and a shorter time to return to work/school after the operation. The postoperative complication and recurrence rates were similar in both groups.
    BACKGROUND: clinicaltrials.gov identifier: NCT05851690. (5/11/2023) (retrospectively registered).
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  • 文章类型: Journal Article
    背景:该研究旨在确定藏毛窦癌(PSD)的生存率和复发率。
    方法:通过检索世界范围内所有以PSD为背景的癌症发展的文献,对数据进行回顾性收集。使用Kaplan-Meier曲线呈现结果。
    结果:在1900年至2022年之间,140例PSD癌发表在103篇论文中,111例病例的随访数据。鳞状细胞癌占病例的94.6%(n=105)。3年的疾病特异性生存率为61.7%,5年内59.8%,和53.2%的10年。分期之间有显著的生存差异:Ⅰ期和Ⅱ期80.0%,第三阶段为70.8%,第四阶段为47.8%(p=0.01)。G1肿瘤的5年生存率优于G2和G3肿瘤,分别为70.5%和32.0%。分别(p=0.002)。46.6%的患者复发。治愈意向治疗患者的复发时间平均为15.1个月(1-132个月)。当地,区域,远处复发占75.6%,33.3%,28.9%的复发性肿瘤,分别。
    结论:毛发窦癌的预后比原发性皮肤鳞状细胞癌的预后差。预后不良的因素包括疾病晚期和分化差。
    BACKGROUND: The study aims to determine the survival and recurrence rates of pilonidal sinus disease (PSD) carcinoma.
    METHODS: The data were collected retrospectively by searching the worldwide literature for all reports of carcinoma developing on the background of PSD. The results were presented using Kaplan-Meier curves.
    RESULTS: Between 1900 and 2022, 140 cases of PSD carcinoma were published in 103 papers, with follow-up data available in 111 cases. Squamous cell carcinoma constituted 94.6% of the cases (n = 105). The disease-specific survival rate was 61.7% for 3 years, 59.8% for 5 years, and 53.2% for 10 years. There was a significant survival difference between stages: 80.0% in stages I and II, 70.8% in stage III, and 47.8% in stage IV (p = 0.01). The 5-year survival in G1-tumors was better than G2 and G3-tumors at 70.5% and 32.0%, respectively (p = 0.002). Recurrence occurred in 46.6% of the patients. The time-to-recurrence in patients treated with curative intention averaged 15.1 months (1-132 months). Local, regional, and distant recurrence was observed in 75.6%, 33.3%, and 28.9% of the recurrent tumors, respectively.
    CONCLUSIONS: Pilonidal sinus carcinoma has a worse prognosis than primary cutaneous squamous cell carcinoma. Poor prognostic factors include advanced-stage disease and poor differentiation.
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  • 文章类型: Journal Article
    这项研究旨在报告有关小儿内镜下藏毛窦治疗(PEPSiT)结果的多中心国家经验。所有儿科病人的医疗记录,18岁以下,在2019-2021年期间接受PEPSiT的患者进行了回顾性审查。患者人口统计学,操作细节,并对术后结果进行评估.共有294名患者(182名男孩),年龄中位数为14岁(10-18岁),在研究期间接受PEPSiT,已注册。鼻窦病(PSD)主要为258例(87.8%),复发为36例(12.2%)。中位手术时间为36分钟(范围11-120)。中位VAS疼痛评分为0.86(范围0-3),镇痛药使用的中位持续时间为27h(范围12-60)。总体成功率为95.2%(280/294),完全愈合的中位时间为23.4天(范围19-50)。6/294(2.0%)患者出现Clavien2术后并发症。复发率为4.8%(14/294),所有复发均使用PEPSiT重新手术。对一名(0.3%)愈合较晚的患者进行了伤口清创的重新手术。在多变量分析中,多毛症和鼻窦类型(小窝≥2,旁正中和更近肛门)是PSD复发的预测因子(p=0.001).迄今为止,这是儿科人群中发表的最大的PEPSiT系列。3年经验后报告的结果证实PEPSiT是安全的,有效,和真正的微创手术来治疗青少年PSD。它为患者提供了快速和无痛的恢复,令人满意的成功,和高质量的生活。
    This study aimed to report a multicentric national experience about the outcomes of pediatric endoscopic pilonidal sinus treatment (PEPSiT). The medical records of all pediatric patients, aged up to 18 years, who underwent PEPSiT in the period 2019-2021, were retrospectively reviewed. Patients\' demographics, operative details, and post-operative outcomes were assessed. A total of 294 patients (182 boys), with median age of 14 years (range 10-18), receiving PEPSiT in the study period, were enrolled. Pilonidal sinus disease (PSD) was primary in 258 (87.8%) and recurrent in 36 (12.2%). The median operative time was 36 min (range 11-120). The median VAS pain score was 0.86 (range 0-3) and the median duration of analgesic use was 27 h (range 12-60). The overall success rate was 95.2% (280/294) and the median time to full healing was 23.4 days (range 19-50). Six/294 (2.0%) patients developed Clavien 2 post-operative complications. The recurrence rate was 4.8% (14/294) and all recurrences were re-operated using PEPSiT. Redo-surgery for wound debridement was performed in one (0.3%) patient with late healing. On multivariate analysis, hirsutism and typology of sinus (pits ≥ 2, paramedian and more proximal to the anus) were predictors of PSD recurrence (p = 0.001). To date, this is the largest series of PEPSiT published in the pediatric population. The outcomes reported after a 3 years experience confirm that PEPSiT is a safe, effective, and real minimally invasive procedure to treat adolescents with PSD. It provides patients quick and painless recovery, satisfactory success, and high quality of life.
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