背景:已提出性别特异性危险因素导致男性患者的藏毛窦疾病(PSD)发病率比女性患者高四倍。然而,近几十年来,PSD在女性中的患病率明显上升,体重和其他危险因素影响疾病。我们的目的是确定PSD患病率是否确实随着时间的推移在男性和女性中发生了变化。
方法:遵循PRISMA指南(PROSPEROID:42016051588),系统检索数据库。1833年至2018年之间以英文发表的关于PSD的论文,法语,德语,选择包含精确数量的男性和女性参与者的意大利语和西班牙语进行分析。几十年来性别特定的PSD患病率是主要的结果衡量标准。
结果:我们筛选了679项研究,报告了104055名患者,发现PSD患者的男女比例随着时间的推移保持不变,所有PSD病例中约有20%的女性受到影响(I2=96.18%;荟萃回归p<0.001)。
结论:虽然PSD的患病率在过去几十年中有所上升,受影响的男性和受影响的女性之间的比例保持不变,尽管发生了广泛的社会经济和行为变化,但女性始终占患者的20%。
BACKGROUND: Gender-specific risk factors have been suggested to promote a fourfold higher incidence of pilonidal sinus disease (PSD) in male as compared to female patients. However, in recent decades there has been an apparent shift towards an increasing prevalence of PSD in women, as body weight and other risk factors influence the disease. We aimed at determining whether PSD prevalence actually changed in men and women over time.
METHODS: Following PRISMA guidelines (PROSPERO ID: 42016051588), databases were systematically searched. Papers reporting on PSD published between 1833 and 2018 in English, French, German, Italian and Spanish containing precise numbers of male and female participants were selected for analysis. Gender-specific prevalence of PSD over several decades was the main outcome measure.
RESULTS: We screened 679 studies reporting on 104 055 patients and found that the male/female ratio in patients with PSD has remained constant over time, with women being affected in about 20% of all PSD cases (I2 = 96.18%; meta-regression p < 0.001).
CONCLUSIONS: While the prevalence of PSD has risen over the past decades, the ratio between affected males and affected females has remained constant, with women invariably representing about 20% of patients despite wide ranging socioeconomic and behavioural changes.