Abstract：
Over the last decades, novel therapeutic options have emerged for the surgical treatment of pilonidal sinus disease (PSD). The aim of this study was to evaluate the outcomes of trephine/pit excision surgery with or without laser therapy in patients with PSD.
A retrospective cohort study was conducted at a large tertiary medical center, including all adult patients with PNS who underwent trephine surgery with/without laser therapy between 2016 and 2021[AUTHORS TO INSERT MONTH]. Propensity score matching was used to address confounding factors, and the primary outcome was the 1-year recurrence rate.
The study included 221 patients with PSD, with a mean age of 23.73 years (87.7% male). In the unmatched cohort (130 trephine surgery alone, 91 trephine surgery + laser therapy), significant differences were observed in mean age (23 vs. 25 years; p < 0.01)[AUTHROS TO USE MEDIAN PLUS RANGE OR ADD SD] and surgeons\' experience (p = 0.014). Propensity score matching was applied to overcome confounding factors, resulting in a matched cohort including 73 patients in each group. The addition of laser therapy demonstrated a significantly lower recurrence rate (8.2% vs. 32.9%; p < 0.001) compared to pit excision without laser therapy. Logistic regression analysis showed that the addition of laser was significantly associated with a lower risk for recurrence (OR 0.23; 95% CI 0.089-0.633; p < 0.01).
The incorporation of laser therapy along with trephine/pit excision surgery significantly reduces the recurrence rate in patients with PNS. Further prospective studies are needed to confirm our findings.
A retrospective cohort study was conducted at a large tertiary medical center, including all adult patients with PNS who underwent trephine surgery with/without laser therapy between 2016 and 2021[AUTHORS TO INSERT MONTH]. Propensity score matching was used to address confounding factors, and the primary outcome was the 1-year recurrence rate.
The study included 221 patients with PSD, with a mean age of 23.73 years (87.7% male). In the unmatched cohort (130 trephine surgery alone, 91 trephine surgery + laser therapy), significant differences were observed in mean age (23 vs. 25 years; p < 0.01)[AUTHROS TO USE MEDIAN PLUS RANGE OR ADD SD] and surgeons\' experience (p = 0.014). Propensity score matching was applied to overcome confounding factors, resulting in a matched cohort including 73 patients in each group. The addition of laser therapy demonstrated a significantly lower recurrence rate (8.2% vs. 32.9%; p < 0.001) compared to pit excision without laser therapy. Logistic regression analysis showed that the addition of laser was significantly associated with a lower risk for recurrence (OR 0.23; 95% CI 0.089-0.633; p < 0.01).
The incorporation of laser therapy along with trephine/pit excision surgery significantly reduces the recurrence rate in patients with PNS. Further prospective studies are needed to confirm our findings.
摘要：
背景：在过去的几十年里，新的治疗方案已经出现了对于毛发窦疾病(PSD)的外科治疗.这项研究的目的是评估PSD患者在有或没有激光治疗的情况下进行环钻/凹陷切除手术的结果。
方法：在大型三级医疗中心进行了一项回顾性队列研究，包括所有在2016年至2021年期间接受有/无激光治疗的环钻手术的PNS成年患者[作者插入月].倾向得分匹配用于解决混杂因素，主要结局是1年复发率.
结果：该研究包括221例PSD患者，平均年龄23.73岁（男性占87.7%）。在无与伦比的队列中(仅130例环钻手术，91环钻手术+激光治疗)，在平均年龄上观察到显著差异(23vs.25年；p<0.01）[使用中距离或ADDSD的权限]和外科医生的经验（p=0.014）。采用倾向得分匹配来克服混杂因素，导致一个匹配的队列，每组包括73名患者。增加激光治疗显示复发率显着降低（8.2％vs.32.9%；p<0.001）与无激光治疗的凹陷切除术相比。Logistic回归分析显示，激光的添加与较低的复发风险显着相关（OR0.23；95％CI0.089-0.633；p<0.01）。
结论：在PNS患者中，激光治疗与环钻/凹陷切除手术的结合显著降低了复发率。需要进一步的前瞻性研究来证实我们的发现。
方法：在大型三级医疗中心进行了一项回顾性队列研究，包括所有在2016年至2021年期间接受有/无激光治疗的环钻手术的PNS成年患者[作者插入月].倾向得分匹配用于解决混杂因素，主要结局是1年复发率.
结果：该研究包括221例PSD患者，平均年龄23.73岁（男性占87.7%）。在无与伦比的队列中(仅130例环钻手术，91环钻手术+激光治疗)，在平均年龄上观察到显著差异(23vs.25年；p<0.01）[使用中距离或ADDSD的权限]和外科医生的经验（p=0.014）。采用倾向得分匹配来克服混杂因素，导致一个匹配的队列，每组包括73名患者。增加激光治疗显示复发率显着降低（8.2％vs.32.9%；p<0.001）与无激光治疗的凹陷切除术相比。Logistic回归分析显示，激光的添加与较低的复发风险显着相关（OR0.23；95％CI0.089-0.633；p<0.01）。
结论：在PNS患者中，激光治疗与环钻/凹陷切除手术的结合显著降低了复发率。需要进一步的前瞻性研究来证实我们的发现。
