目的:我们的目的是分析与腮腺皮肤转移头颈部SCC不良生存结局相关的危险因素。
方法:对2011年至2018年期间因腮腺转移性皮肤SCC而接受手术治疗的所有患者进行回顾。评估了人口统计学和临床特征。组织病理学数据,包括肿瘤大小和组织学,肿瘤分级,TNM阶段,切除边缘,淋巴管浸润,和神经周浸润,进行了分析。总生存期(OS),疾病特异性生存率(DSS),并评估了局部区域复发的自由度(LRR)。
结果:包括90例患者(平均年龄,77岁;75名男性[83.3%])。48例患者(53.3%)进行了全腮腺切除术,42例(46.7%)接受了浅表腮腺切除术。70例(77.8%)患者接受辅助放疗。中位随访时间为31个月(20~39个月)。肿瘤体积≥50cm3和较短的RT持续时间(<20天)与OS降低相关(分别为p=0.002和p=0.01,p=0.02和p=0.009),和DSS(p=0.004和p=0.02,p=0.04和p=0.02,分别)在单变量和多变量分析,分别。在单变量和多变量分析中,只有较短的RT持续时间与LRR的较差的自由度相关。(分别为p=0.04和p<0.001)。然而,死亡是一种相互竞争的风险,较短的RT持续时间与LRR无明显相关性.
结论:佐剂RT的持续时间较短,切除的肿瘤体积≥50cm3是OS和DSS降低的预测因素,在转移性SCC至腮腺的患者中,较短的RT持续时间也与LRR的自由度降低相关。
方法:4级喉镜,2022年。
We aimed to analyze risk factors associated with poor survival outcomes for metastatic cutaneous head-and-neck SCC to the parotid.
All patients undergoing surgery for metastatic cutaneous SCC to the parotid with curative intent between 2011 and 2018, were reviewed. Demographic and clinical characteristics were evaluated. Histopathological data including tumor size and histology, tumor grade, TNM stage, resection margins, lymphovascular invasion, and perineural invasion, were analyzed. Overall survival (OS), disease-specific survival (DSS), and freedom from locoregional recurrence (LRR) were assessed.
Ninety patients were included (mean age, 77 years; 75 men [83.3%]). A total parotidectomy was performed in 48 patients (53.3%), and 42 (46.7%) underwent a superficial parotidectomy. Seventy patients (77.8%) underwent adjuvant RT. The median follow-up was 31 months (20-39 months). Tumor volume ≥ 50 cm3 and a shorter RT duration (<20 days) were associated with reduced OS (p = 0.002 and p = 0.01, p = 0.02 and p = 0.009, respectively), and DSS (p = 0.004 and p = 0.02, p = 0.04 and p = 0.02, respectively) on univariable and multivariable analysis, respectively. Only a shorter RT duration was associated with worse freedom from LRR on univariable and multivariable analysis, (p = 0.04 and p < 0.001, respectively). However, with death as a competing risk, a shorter duration of RT was not significantly associated with freedom from LRR.
A shorter duration of adjuvant RT, and excised tumor volume ≥50 cm3 were predictive factors of reduced OS and DSS, and a shorter duration of RT was also associated with reduced freedom from LRR in patients with metastatic SCC to the parotid gland.
4 Laryngoscope, 133:1163-1168, 2023.