■粘液表皮样癌(MEC)是腮腺最常见的恶性肿瘤,但结果取决于组织学分级.因此,本研究的目的是根据组织学分级评估MEC.
■回顾性分析。
■我们对1999年至2021年在我科进行腮腺MEC初始治疗的患者的数据进行了回顾性分析。我们检查了武装部队病理学研究所(AFIP)等级与结果之间的关联。
■AFIP等级如下:低,26例;中级,9例;和高,31例。大约50%的病例被正确诊断为恶性,20%的病例通过细针穿刺细胞学检查准确确定了分级和组织学。低/中/高级别病例的5年无病生存率分别为95.5%和53.8%,分别。在高级组,发现复发的患者淋巴结转移率高于未复发的患者。此外,在这个高级团体中,完全处死面神经并不能减少局部复发.然而,在没有肿瘤侵犯神经的情况下,根治性切除术降低了局部复发率。CRTC1-MAML2融合基因在42.3%的低/中和14.3%的高级别病例中表达。
■低/中/高级别病例的MEC生存率差异很大。然而,细针穿刺细胞学对分级的正确评估率很低.在高级案件中,在没有侵犯神经主干的情况下,完全杀死面神经可以提高局部复发率。CRTC1-MAML2融合基因的表达不仅有助于分级的评估,而且有助于复发的预测。
■4.
UNASSIGNED: Mucoepidermoid carcinoma (MEC) is the most common malignancy of the parotid gland, but the outcome depends on the histological grade. Therefore, the aim of this study was to evaluate MEC on the basis of histological grade.
UNASSIGNED: Retrospective analysis.
UNASSIGNED: We performed a retrospective analysis of data from patients whose initial treatment for MEC of the parotid gland was performed at our department between 1999 and 2021. We examined the association between the Armed Forces Institute of Pathology (AFIP) grade and outcome.
UNASSIGNED: The AFIP grades were as follows: low, 26 cases; intermediate, 9 cases; and high, 31 cases. About 50% of cases were correctly diagnosed as malignant, and both grade and histology were accurately determined by fine-needle aspiration cytology in 20% of cases. The 5-year disease-free survival rate was 95.5% and 53.8% in the low-/intermediate- and high-grade cases, respectively. In the high-grade group, cases with recurrence were found to have a higher rate of lymph nodes metastasis than cases without recurrence. Furthermore, in this high-grade group, total sacrifice of the facial nerve did not reduce local recurrence. However, radical resection in the cases without tumor invasion to the nerve has decreased the local recurrence rate. The CRTC1-MAML2 fusion gene was expressed in 42.3% of low-/intermediate- and 14.3% of high-grade cases.
UNASSIGNED: The survival rate in MEC was quite different between the low-/intermediate- and high-grade cases. However, the rate of correct assessment of the grade by fine-needle aspiration cytology was poor. In high-grade cases, total sacrifice of the facial nerve may improve the rate of local recurrence in cases without invasion of the main trunk of the nerve. Expression of the CRTC1-MAML2 fusion gene could be helpful in not only the assessment of grade but the prediction of recurrence.
UNASSIGNED: 4.