肥厚性瘢痕是一种异常的伤口愈合反应,在受伤后重建皮肤完整性,并可能导致身体上的显著异常,美学,功能,和心理症状,影响患者的生活质量。目前没有预防和治疗肥厚性疤痕的黄金标准。因此,许多研究人员试图寻找疗效更大、副作用更少的抗增生性瘢痕药物。由于其高效,自然疗法作为潜在的替代抗瘢痕形成剂正变得有吸引力。安全,生物相容性,低成本,和容易获得。这篇综述展示了各种基于天然产物的疗法,包括洋葱,维生素E,GotuKola,绿茶,白藜芦醇,大黄素,姜黄素,和其他人,就他们的行动机制而言,有效性和安全性的证据,优势,和缺点时用作抗瘢痕形成剂。我们根据体外数据回顾了文献,在体内,和临床试验。本综述共确定了23项临床试验;大多数临床试验被列为结果不确定(证据水平2b;n=16)。尽管这些天然产物在潜在的抗瘢痕形成剂的体外和体内研究中显示出有益的作用,由于研究质量有限,支持其疗效的临床证据有限,具有个别缺陷,包括小样本量,随机性差,致盲,随访时间短。需要具有大规模和延长随访持续时间的更强大和精心设计的临床试验来阐明这些药物的益处和风险。
Hypertrophic scarring is an aberrant wound-healing response to reestablish dermal integrity after an injury and can cause significant abnormalities in physical, aesthetic, functional, and psychological symptoms, impacting the patient\'s quality of life. There is currently no gold standard for preventing and treating hypertrophic scars. Therefore, many researchers have attempted to search for antihypertrophic scar agents with greater efficacy and fewer side effects. Natural therapeutics are becoming attractive as potential alternative anti-scarring agents because of their high efficacy, safety, biocompatibility, low cost, and easy accessibility. This review demonstrates various kinds of natural product-based therapeutics, including onion, vitamin E, Gotu kola, green tea, resveratrol, emodin, curcumin, and others, in terms of their mechanisms of action, evidence of efficacy and safety, advantages, and disadvantages when used as anti-scarring agents. We reviewed the literature based on data from in vitro, in vivo, and clinical trials. A total of 23 clinical trials were identified in this review; most clinical trials were ranked as having uncertain results (level of evidence 2b; n = 16). Although these natural products showed beneficial effects in both in vitro and in vivo studies of potential anti-scarring agents, there was limited clinical evidence to support their efficacy due to the limited quality of the studies, with individual flaws including small sample sizes, poor randomization, and blinding, and short follow-up durations. More robust and well-designed clinical trials with large-scale and prolonged follow-up durations are required to clarify the benefits and risks of these agents.