Abstract：
Precise control of norepinephrine (NE) levels and NE-receptor interaction is crucial for proper function of the brain. Much evidence for this view comes from experimental studies that indicate an important role for NE in the pathophysiology and treatment of various conditions, including cognitive dysfunction, Alzheimer\'s disease, Parkinson\'s disease, multiple sclerosis, and sleep disorders. NE provides neuroprotection against several types of insults in multiple ways. It abrogates oxidative stress, attenuates neuroinflammatory responses in neurons and glial cells, reduces neuronal and glial cell activity, promotes autophagy, and ameliorates apoptotic responses to a variety of insults. It is beneficial for the treatment of neurodegenerative diseases because it improves the generation of neurotrophic factors, promotes neuronal survival, and plays an important role in the regulation of adult neurogenesis. This review aims to present the evidence supporting a principal role for NE in neuroprotection, and molecular mechanisms of neuroprotection.
摘要：
精确控制去甲肾上腺素（NE）水平和NE-受体相互作用对于大脑的正常功能至关重要。这种观点的许多证据来自实验研究，表明NE在各种疾病的病理生理学和治疗中的重要作用。包括认知功能障碍,老年痴呆症,帕金森病,多发性硬化症,和睡眠障碍。NE以多种方式提供针对几种类型的损伤的神经保护。它消除了氧化应激，减弱神经元和神经胶质细胞的神经炎症反应，减少神经元和神经胶质细胞的活性，促进自噬，并改善对各种侮辱的细胞凋亡反应。它有利于神经退行性疾病的治疗，因为它改善了神经营养因子的产生，促进神经元存活，并在成人神经发生的调节中起着重要作用。这篇综述旨在提供支持NE在神经保护中的主要作用的证据。和神经保护的分子机制。
