■心力衰竭(HF)对皮质脑结构的影响尚不清楚。因此,本研究旨在利用孟德尔随机化(MR)分析,探讨心力衰竭对大脑皮质结构的因果影响.
■我们利用遗传预测的HF性状进行了双样本MR分析,左心室射血分数(LVEF),和N末端激素原脑钠肽(NT-proBNP)水平,以检查它们对34个皮质脑区域的皮质表面积(SA)和厚度(TH)的影响。全基因组关联研究总结数据从Rasooly(1,266,315名参与者)的HF性状研究中提取,施密特(36,548名参与者)参加LVEF,NT-proBNP的SCALLOP联盟(21,758名参与者),以及皮质SA和TH的ENIGMA联盟(51,665名参与者)。一系列的MR分析被用来排除异质性和多效性,确保结果的稳定性。鉴于这项研究的探索性,1.22E-04和0.05之间的p值被认为是关联,和低于1.22E-04的p值被定义为具有统计学意义。
■在这项研究中,我们发现HF与皮质TH或SA之间没有显著关联(所有p>1.22E-04)。我们发现HF特性和升高的NT-proBNP水平与皮质SA无关,但建议减少眼眶的皮质TH,外侧眶额皮质,颞极,舌回,precuneus,和颈上回。LVEF降低主要被认为是降低峡部扣带回的皮质SA,额叶极点,中央后回,Cuneus,和额叶中回,以及中央后回的TH。然而,建议后扣带回和内侧眶额皮质的SA以及内嗅皮质和颞上回的TH有因果关系。
■我们发现了15个可能受HF影响的脑区,这可能会导致认知障碍,情感,感知,记忆,语言,感官加工,愿景,HF患者的执行控制。
UNASSIGNED: The effects of heart failure (HF) on cortical brain structure remain unclear. Therefore, the present study aimed to investigate the causal effects of heart failure on cortical structures in the brain using Mendelian randomization (MR) analysis.
UNASSIGNED: We conducted a two-sample MR analysis utilizing genetically-predicted HF trait, left ventricular ejection fraction (LVEF), and N-terminal prohormone brain natriuretic peptide (NT-proBNP) levels to examine their effects on the cortical surface area (SA) and thickness (TH) across 34 cortical brain regions. Genome-wide association study summary data were extracted from studies by Rasooly (1,266,315 participants) for HF trait, Schmidt (36,548 participants) for LVEF, the SCALLOP consortium (21,758 participants) for NT-proBNP, and the ENIGMA Consortium (51,665 participants) for cortical SA and TH. A series of MR analyses were employed to exclude heterogeneity and pleiotropy, ensuring the stability of the results. Given the exploratory nature of the study, p-values between 1.22E-04 and 0.05 were considered suggestive of association, and p-values below 1.22E-04 were defined as statistically significant.
UNASSIGNED: In this study, we found no significant association between HF and cortical TH or SA (all p > 1.22E-04). We found that the HF trait and elevated NT-proBNP levels were not associated with cortical SA, but were suggested to decrease cortical TH in the pars orbitalis, lateral orbitofrontal cortex, temporal pole, lingual gyrus, precuneus, and supramarginal gyrus. Reduced LVEF was primarily suggested to decrease cortical SA in the isthmus cingulate gyrus, frontal pole, postcentral gyrus, cuneus, and rostral middle frontal gyrus, as well as TH in the postcentral gyrus. However, it was suggested to causally increase in the SA of the posterior cingulate gyrus and medial orbitofrontal cortex and the TH of the entorhinal cortex and superior temporal gyrus.
UNASSIGNED: We found 15 brain regions potentially affected by HF, which may lead to impairments in cognition, emotion, perception, memory, language, sensory processing, vision, and executive control in HF patients.