%0 Journal Article
%T Lack of genetic association of non-melanoma skin cancer and pseudoexfoliative glaucoma.
%A Beneke AA
%A Wiese JD
%A Root KT
%A Taneja K
%A Beal CJ
%J Ophthalmic Genet
%V 0
%N 0
%D 2024 Aug 15
%M 39148320
%F 1.274
%R 10.1080/13816810.2024.2390008
%X <B>UNASSIGNED: </B>Prior research has shown a positive association of pseudoexfoliative glaucoma (PXG) in patients with non-melanoma skin cancer (NMSC), likely due to an increase in ultraviolet exposure associated with both. However, the role of NMSC as a genetic risk factor for PXG has not been examined. Thus, the goal of this study is to utilize Mendelian randomization with genome-wide association studies to evaluate for genetic causality while controlling for environmental confounders.<BR><B>UNASSIGNED: </B>We conducted a MR using the inverse variance weighted method (MR-IVW) as our primary analysis. Genomic data was sourced from GWASs for patients with NMSC (10,382 cases, 208,410 controls) and PXG (1,515 cases and 210,201 controls), originating from the FinnGen Biobank.<BR><B>UNASSIGNED: </B>Despite previous association of history of NMSC with occurrence of PXG, we found no evidence for a causal association between SNPs associated with NMSC and risk of PXG following MR analysis (MR-IVW, odds ratio (OR): 0.98, 95% CI: 0.85-1.14, P = 0.87).<BR><B>UNASSIGNED: </B>Here, we found no evidence for a causal association between SNPs associated with NMSC and the risk of PXG following a MR analysis.