背景:先前的研究报道了成人中血细胞指数失调和外周炎症标志物与抑郁症的相关性,但有限的研究在青少年早期研究了这种相关性。
方法:本研究使用中国早期青少年队列研究的数据,这是在安徽进行的,中国。使用中文版的儿童流行病学研究中心抑郁量表反复测量学生的抑郁症状。学生的血液样本是在2019年9月和2021年9月收集的。使用血常规检测外周血细胞计数和炎症标志物水平。在整个样本和性别分层样本中,使用多变量回归模型来探索血细胞指数与青少年抑郁症状之间的关联。
结果:白细胞(WBC)计数,中性粒细胞计数(NC),血小板(PLT)计数,中性粒细胞与淋巴细胞比率(NLR),血小板与淋巴细胞比率,全身免疫炎症指数(SII)与随访期间抑郁症状严重程度呈正相关。平均红细胞体积(MCV),平均血红蛋白(HGB)体积(MCH),平均红细胞HGB浓度(MCHC)与抑郁症状呈时间负相关。此外,几种性别特异性血细胞标志物与抑郁症相关.红细胞(RBC)增加的男性青少年和HGB水平降低和WBC上调的女性青少年,NC,NLR,和SII水平在随访时表现出严重的抑郁症状。
结论:这些发现提示外周血细胞指数在评估青少年早期抑郁中的潜在作用。
BACKGROUND: Previous studies have reported the correlation of dysregulated blood cell indices and peripheral inflammatory markers with depression in adults but limited studies have examined this correlation in early adolescents.
METHODS: This study used data from the Chinese Early Adolescents Cohort Study, which was conducted in Anhui, China. Students\' depression symptoms were repeatedly measured using the Chinese version of the Center for Epidemiological Studies Depression Scale for Children. Students\' blood samples were collected in September 2019 and September 2021. The peripheral blood cell counts and inflammatory marker levels were determined using routine blood tests. Multivariate regression models were used to explore the associations between blood cell indices and adolescent depressive symptoms in both the whole sample and the sex-stratified samples.
RESULTS: The white blood cell (WBC) count, neutrophil count (NC), platelet (PLT) count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, and systemic immune inflammation index (SII) were positively correlated with the severity of depressive symptoms during follow-up. The mean corpuscular volume (MCV), mean hemoglobin (HGB) volume (MCH), and mean corpuscular HGB concentration (MCHC) exhibited a negative temporal correlation with depressive symptoms. Additionally, several sex-specific blood cell markers were correlated with depression. Male adolescents with increased red blood cell (RBC) and female adolescents with decreased HGB levels and upregulated WBC, NC, NLR, and SII levels exhibited severe depressive symptoms at follow-up.
CONCLUSIONS: These findings suggested the potential usefulness of peripheral blood cell indices in the assessment of depression in early adolescents.